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| Registros recuperados: 95 | |
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| MENDIBURO,MARÍA JOSE; FLORES,SEBASTIÁN; PIZARRO,FERNANDO; ARREDONDO,MIGUEL. |
| Heme oxygenase-1 is a microsomal enzyme that, when induced by stress, protects the cells from oxidative injury. Heme oxygenase-1 participates in the cleavage of the heme ring producing biliverdin, CO and ferrous Fe. The released Fe becomes part of intracellular Fe pool and can be stored in ferritin or released by an iron exporter. The mechanism by which heme enters cells is not completely understood, although it had been suggested that it might be internalized by an endocytosis process. In this study, we expressed a full-length Heme oxygenase-1 cDNA in Caco-2 cells and measured intracellular iron content, heme-iron uptake and transport and immunolocalization of heme oxygenase-1 in these cells. We found that heme oxygenase-1 expressing cells showed... |
| Tipo: Journal article |
Palavras-chave: Iron; Heme; Heme oxygenase; Caco-2 cells. |
| Ano: 2006 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100023 |
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| Pal,Rahul; Hameed,Saif; Sharma,Sharda; Fatima,Zeeshan. |
| ABSTRACT Novel strategies to combat the ever increasing burden of drug resistance in Mycobacterium tuberculosis (MTB) causing tuberculosis (TB) remains a global concern. The ability of MTB to sense and adapt to restricted iron conditions in the hostile environment is essential for their survival and confers the basis of their success as dreadful pathogen. The striking and clinically relevant virulence trait of MTB is its ability to form biofilms and adhere to the host cells. The present study elucidated the effect of iron deprivation on biofilm formation and cell adherence of Mycobacterium smegmatis, a non-pathogenic surrogate of MTB. Firstly, we showed that iron deprivation leads to enhanced cell sedimentation rate and altered colony morphology depicting... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Iron; Morphology; Biofilm; Anti-TB drugs. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600585 |
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| Ferreira,A.L.A.; Machado,P.E.A.; Matsubara,L.S.. |
| The free form of the iron ion is one of the strongest oxidizing agents in the cellular environment. The effect of iron at different concentrations (0, 1, 5, 10, 50, and 100 µM Fe3+) on the normal human red blood cell (RBC) antioxidant system was evaluated in vitro by measuring total (GSH) and oxidized (GSSG) glutathione levels, and superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px) and reductase (GSH-Rd) activities. Membrane lipid peroxidation was assessed by measuring thiobarbituric acid reactive substance (TBARS). The RBC were incubated with colloidal iron hydroxide and phosphate-buffered saline, pH 7.45, at 37oC, for 60 min. For each assay, the results for the control group were: a) GSH = 3.52 ± 0.27 µM/g Hb; b) GSSG = 0.17 ± 0.03... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Catalase; Superoxide dismutase; Glutathione; Iron; Erythrocyte; Thiobarbituric acid reactive substance. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000600004 |
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| Ferraz,H.B.; Quagliato,E.A.B.; Rieder,C.R.M.; Silva,D.J.; Teive,H.A.G.; Barbosa,E.R.; Cardoso,F.; Limongi,J.C.P.; Bezerra,J.M.F.; Andrade,L.A.F.; Allam,N.; Prado,R.C.P.; Tomas,V.. |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Parkinson's disease; Riboflavin; FAD; Glutathione; Iron; Hemin. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000900002 |
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| Coimbra,C.G.; Junqueira,V.B.C.. |
| Abnormal riboflavin status in the absence of a dietary deficiency was detected in 31 consecutive outpatients with Parkinson's disease (PD), while the classical determinants of homocysteine levels (B6, folic acid, and B12) were usually within normal limits. In contrast, only 3 of 10 consecutive outpatients with dementia without previous stroke had abnormal riboflavin status. The data for 12 patients who did not complete 6 months of therapy or did not comply with the proposed treatment paradigm were excluded from analysis. Nineteen PD patients (8 males and 11 females, mean age ± SD = 66.2 ± 8.6 years; 3, 3, 2, 5, and 6 patients in Hoehn and Yahr stages I to V) received riboflavin orally (30 mg every 8 h) plus their usual symptomatic medications and all red... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parkinson's disease; Riboflavin; Flavin-adenine dinucleotide; Glutathione; Iron; Hemin. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000019 |
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| Paula,Daphine Ariadne Jesus de; Silva,Lívia Kmetzsch Rosa e; Staats,Charley Christian; Vainstein,Marilene H.; Joanoni,Ana Lúcia Pinto; Nakazato,Luciano; Dutra,Valéria. |
| Cryptococcus neoformans and C. gattii are pathogenic yeasts that cause life-threatening diseases in humans and animals. Iron is an essential nutrient for virtually every organism as it functions as a cofactor in numerous essential enzymatic reactions. In the literature, the competition for iron between microbes and mammalian hosts during infection is well documented. In this study, we used representational difference analysis (RDA) in order to gain a better understanding of how C. gattii responds to iron starvation. A total of 15 and 29 genes were identified as having altered expression levels due to iron depletion after 3 h and 12 h, respectively. Of these, eight genes were identified in both libraries. The transcripts were related to many biological... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cryptococcus gattii; Iron; Representational difference analysis; Yeast. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000300008 |
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| Liu,Di; Yang,Qianqian; Ge,Ke; Hu,Xiuna; Qi,Guozhen; Du,Binghai; Liu,Kai; Ding,Yanqin. |
| ABSTRACT This study aimed to explore the effects of two siderophore-producing bacterial strains on iron absorption and plant growth of peanut in calcareous soil. Two siderophore-producing bacterial strains, namely, YZ29 and DZ13, isolated from the rhizosphere soil of peanut, were identified as Paenibacillus illinoisensis and Bacillus sp., respectively. In potted experiments, YZ29 and DZ13 enhanced root activity, chlorophyll and active iron content in leaves, total nitrogen, phosphorus and potassium accumulation of plants and increased the quality of peanut kernels and plant biomass over control. In the field trial, the inoculated treatments performed better than the controls, and the pod yields of the three treatments inoculated with YZ29, DZ13, and YZ29 +... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Plant growth-promoting rhizobacteria; Peanut; Paenibacillus illinoisensis; Siderophores; Iron. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000400656 |
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| Rocha,Ricardo Xavier da; Bondan,Carlos; Marinho,Roberto; Lopes,Sônia Terezinha dos Anjos; Cecim,Marcelo. |
| Anemia due to worm infection is a major cause of loss in the sheep industry, due to deaths, drop in average daily gains and long recovery time following treatment. The present experiment was aimed at evaluating the oxidative status and the recovery of red blood cell (RBC) profile in lambs with induced anemia by bleeding, treated or not with dextran iron. Ten ram lambs 5 to 7 months old were used. Blood samples were drawn every other day and when reached packed cell volume (PCV) of 15% were randomly allocated (day zero) to one of the experimental groups. Treated group received a single dose of 25mg per kg body weight of a commercial formulation of dextran iron, the control group received no treatment. Blood samples were taken on days 0, 7, 14, and 21 after... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: TBARS; NPTH; Lambs; Free-radicals; Iron. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000500019 |
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| Tabaldi,Luciane Almeri; Castro,Gabriel Y; Cargnelutti,Denise; Skrebsky,Etiane Caldeira; Gonçalves,Jamile Fabbrin; Rauber,Renata; Rossato,Liana; Schetinger,Maria Rosa Chitolina; Bisognin,Dílson Antônio; Nicoloso,Fernando Teixeira. |
| The objective of this study was to evaluate the effects of aluminum (Al) on the zinc (Zn), manganese (Mn), iron (Fe) and copper (Cu) concentrations in four potato clones (Macaca and Dakota Rose: both Al-sensitive clones; and SMIC148-A and Solanum microdontum: both Al-tolerant-clones), grown in a nutrient solution (pH 4.00) with 0, 50, 100, 150 and 200mg Al L-1. Root Zn and Fe concentrations decreased linearly with the increase of Al levels in Macaca, SMIC148-A and Dakota Rose and increased linearly in S. microdontum. Shoot Zn concentration showed a quadratic relationship with Al in S. microdontum and SMIC148-A, but a curvilinear response in Dakota Rose. Shoot Fe concentration showed a quadratic relationship with Al in S. microdontum, SMIC148-A and Dakota... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Solanum tuberosum; Solanum microdontum; Zinc; Manganese; Iron; Copper. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000200010 |
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