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| Registros recuperados: 90 | |
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| Sher,Muhammad; Ahmad,Maria; Hassan,Faiza; Naeem-ul-Hassan,Muhammad; Hussain,Muhammad Ajaz. |
| A reverse phase high performance liquid chromatography method has been developed and validated for accelerated stability study and determination of pharmacokinetic parameters of venlafaxine HCl. The chromatographic separation was carried out using ODS analytical column (250 × 4.6 mm i.d., 5 µm particle size). The mobile phase included acetonitrile, methanol and potassium dihydrogen phosphate buffer (30:30:40; pH 6.1) at a flow rate 1.5 mL min−1. UV-Visible detector was used at wavelength of 227 nm to monitor elutions. Retention time observed was 2.745 min. The method was validated for linearity, accuracy, precision, sensitivity and robustness. Accelerated stability study of venlafaxine HCl capsules was carried out at 40 and 50 ºC under 75% RH level.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Venlafaxine; HPLC; Stability; Pharmacokinetics; Chromatography. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100514 |
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| Silva,Márcio Robert Mattos da; Dysars,Letícia Pereira; Santos,Elisabete Pereira dos; Ricci Júnior,Eduardo. |
| At the hospital, the pharmacist is constantly challenged to prepare extemporaneous solutions from tablets, capsules or drug powder for patients unable to swallow, such as pediatric, elderly and patients that use nasoenteric and nasogastric tubes. The preparation of extemporaneous solutions from capsules, tablets and drug powder requires stability studies analysis. This article is a bibliographic review of preparation of extemporaneous oral liquid from solid oral dosage forms used in clinical practice. The selected articles contain all the information regarding manipulation techniques, pharmaceutical excipients, packaging, storage conditions and results of stability studies above 90% performed by HPLC analysis. In addition, a situational analysis of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Extemporaneous oral liquid; Stability; Hospital pharmacy. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100703 |
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| Fernandes,Alessandra Ribeiro; Dario,Michelli Ferrera; Pinto,Claudinéia Aparecida Sales de Oliveira; Kaneko,Telma Mary; Baby,André Rolim; Velasco,Maria Valéria Robles. |
| Rising global demand for natural products whose production is harmless to the environment has stimulated the development of natural cosmetics and, within this category, organics (95% organic raw materials). The image of environmentally friendly production is one of the strongest attractions of organic products. Lip balm is a cosmetic product similar to lipstick whose purpose is to prevent lip dryness and protect against adverse environmental factors. The product's characteristics are: resistance to temperature variations, pleasant flavor, innocuousness, smoothness during application, adherence and easy intentional removal. This work involved the development of a lip balm formulated with certified organic raw materials and the execution of stability tests:... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lip balm; Stability; Cocoa butter; Cosmetic; Organic. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200011 |
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| He,Suna; Wang,Bowen; Zhang,Runfang; Zhou,Huanhuan; Yang,Qian. |
| The development and clinical application of 2-methoxyestradiol (2-ME) as a new type of antitumor drug are limited due to its poor solubility, rapid metabolism in vivo, and large oral dosage. 2-ME-loaded pH-sensitive liposomes (2-ME-PSLs) was prepared containing the lipids, Lipoid E-80 (E-80), cholesteryl hemisuccinate (CHEMS), and cholesterol (CHOL) via thin-film ultrasonic dispersion. First, preparation conditions of 2-ME-PSLs were optimized by orthogonal test. Then 2-ME-PSL was characterized, and the release behavior and stability of 2-ME-PSL in vitro were evaluated. The optimal preparation conditions for 2-ME-PSLs were as follows: 2-ME : E-80+CHEMS 1:15; CHOL : E-80+CHEMS 1:5; ultrasonication time 20 minutes. The mean particle size, PDI, zeta potential,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 2-Methoxyestradiol; PH sensitive liposomes; In vitro release; Stability. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100544 |
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| Castillo,Hugo; Hernández,Adriana; Dominguez,David; Ojeda,Damaris. |
| The efficiency of composting processes with and without the addition of Californian red worms (Eisenia foetida) was evaluated, using manure of dairy cows to generate organic fertilizer. Several parameters were assessed as physio-chemical indicators of maturity, such as temperature, pH, C/N ratio, phytotoxicity and macro and micronutrients at 25 and 54 ws (mature and stored products, respectively). A linear model was used in the statistical analysis, with four replicates that included as fixed effects, the composting systems and time. At 25 wk, both systems reduced the C/N ratio to values of 15.5 in vermicompost and 17.1 in semi-compost. The content of total N, N-NO3, Ca and some micronutrients also increased. K and Na concentrations were higher in the... |
| Tipo: Journal article |
Palavras-chave: Fertilizer; Organic; Maturation; Stability. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-58392010000300014 |
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| Cordeiro,Cecília de Souza; Forato,Lucimara Aparecida; Bernardes Filho,Rubens; Nassu,Renata Tieko. |
| ABSTRACT: During the shelf-life of fresh meat, physical, chemical, microbiological, and sensory changes may occur. To avoid such changes, the combination of vacuum-packaging and use of edible coatings make a good strategy. This study aimed to evaluate the physicochemical characteristics of vacuum-packaged lamb meat combined with different zein-based edible coatings containing different vegetable oils (pink pepper, rosemary, olive oil, and the combinations of olive oil + pink pepper or rosemary), stored at 5 ± 1 °C. Parameters including pH, instrumental color, water holding capacity (WHC), shear force, and thiobarbituric acid reactive substances (TBARS) were analyzed every seven days, for 29 days. Significant differences (P<0.05) were observed in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Packaging; Plasticizers; Stability. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019001000753 |
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| Heidtmann-Bemvenuti,Renata; Nora,Náthali Saião; Badiale-Furlong,Eliana. |
| γ-oryzanol, a phytochemical, has antioxidant activities and potential health benefits. In this study, we aimed to develop a method for extracting high amounts of γ-oryzanol from rice bran and for verifying its stability in different solvents. Of the 5 methods under investigation, the one that yielded the highest γ-oryzanol content was further improved by using a central composite rotational design (DCCR - 2(4), including 8 tests in axial conditions and 4 central points, totaling 28 trials). The parameters under study were temperature, time, volume, and the ratio of hexane:isopropanol. High γ-oryzanol content (13.98 mg.g-1) was obtained by using the following extraction conditions: 40° C, 40 min, and 75 mL hexane:isopropanol (1:3). The limits of detection... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antioxidant; Spectrophotometer; Stability; Phytochemistry. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542012000600008 |
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| Registros recuperados: 90 | |
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