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| Registros recuperados: 1.286 | |
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| Shah,Rehmat; Subhan,Fazal; Sultan,Syed Muhammad; Haq,Matiul; Ahmad,Hussain; Khan,Qasim Riaz; Ali,Gowhar; Ullah,Sami; Ullah,Ihsan. |
| Antipsychotic Drugs (APDs) are being widely prescribed to treat various disorders, including schizophrenia and bipolar disorder; however, abnormal glucose metabolism and weight gain have been reported with Atypical Anti-Psychotic drugs (AAPDs) that can lead to insulin-resistance and type 2 diabetes mellitus. The study was designed to assess various biochemical parameters including insulin and blood sugar before and after exposure to APDs in order to exclude the involvement of psychiatric disorders and certain other factors in metabolic dysregulations. Fifty seven APDs-naïve patients with first episode psychosis were divided into six groups who received olanzapine, quetiapine, risperidone, aripiprazole, haloperidol or combination of olanzapine with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Olanzapine; Quetiapine; Risperidone; Antipsychotics; Pancreas; Insulin. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100535 |
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| Casavechia,Maria Teresinha Gomes; Silveira,Thaís Gomes Verzignassi; Teodoro,Ueslei; Janeiro,Vanderly; Udo,Margareth; Campana Lonardoni,Maria Valdrinez. |
| The purpose of this study was to investigate the relationship of several variables to the healing of lesions in patients with American cutaneous leishmaniasis (ACL). The patients with clinical and/or laboratorial diagnoses of the disease were followed up for varying periods after treatment by clinical evaluation and indirect immunofluorescence assay (IFA), from September 2000 to December 2003. The lesions of 85.3% of the 163 patients had healed by their last return for clinical evaluation, and of these, 82.7% had negative IFA results, indicating an association between the healing of lesions and IFA negativity (p=0.000). In patients evaluated up to 120 days after treatment, there was a significant association between negative IFA results and the healing of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cutaneous leishmaniasis/treatment; Leishmania (Viannia) braziliensis; Cutaneous lesion/healing. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400030 |
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| Çelebier,Mustafa; Reçber,Tuba; Koçak,Engin; Altinöz,Sacide. |
| Rivaroxaban, an anti-clotting medication, acts at a crucial point in the blood-clotting process and stops the formation of blood clots. In this study, RP-HPLC method was developed for the determination of rivaroxaban in tablets (Xarelto® (10 mg)). Phenomenex Luna 5 µm C18 100 Å LC Column (250 x 4.6 mm) was used at 40 ºC. Isocratic elution was performed with ACN:Water (55:45 v/v) mixture. The flow rate was 1.2 mL min-1 and UV detection was at 249 nm. Internal standard (Caffeine) and rivaroxaban were eluted within 2.21 and 3.37 minutes, respectively. The developed method was validated according to the ICH guidelines and found to be linear within the range 0.005 - 40.0 µg mL-1. The method was accurate, precise, robust and rapid. Thus, it was applied... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HPLC; Rivaroxaban; Validation; System suitability; Stability-indicating; Pharmaceutical dosage form. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200018 |
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| Gupta,Manish Kumar; Prakash,Deepak; Mishra,Brahmeshwar. |
| The efficacy of a drug in a specific application requires the maintenance of appropriate drug blood level concentration during a prolonged period of time. Controlled release delivery is available for many routes of administration and offers many advantages (as microparticles and nanoparticles) over immediate release delivery. These advantages include reduced dosing frequency, better therapeutic control, fewer side effects, and, consequently, these dosage forms are well accepted by patients. Advances in polymer material science, particle engineering design, manufacture, and nanotechnology have led the way to the introduction of several marketed controlled release products and several more are in pre-clinical and clinical development. The objective of this... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diltiazem HCl loaded microparticles/preparation; Diltiazem HCl loaded microparticles/release profile; Diltiazem HCl loaded microparticles/evaluation; Albumin/microparticles; Microparticles batches/diffusion kinetics; Cloridrato de diltiazem/associado a micropartículas; Cloridrato de diltiazem/avaliação do perfil de liberação. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400014 |
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| Sohail,Kashif; Khan,Ikram Ullah; Shahzad,Yasser; Hussain,Talib; Ranjha,Nazar Muhammad. |
| In this study, we fabricated pH-sensitive polyvinylpyrrolidone/acrylic acid (PVP/AA) hydrogels by a free-radical polymerisation method with variation in the content of monomer, polymer and cross-linking agent. Swelling was performed in USP phosphate buffer solutions of pH 1.2, 5.5, 6.5 and 7.5 with constant ionic strength. Network structure was evaluated by different parameters and FTIR confirmed the formation of cross-linked hydrogels. X-ray crystallography showed molecular dispersion of tramadol HCl. A drug release study was carried out in phosphate buffer solutions of pH 1.2, 5.5 and 7.5 for selected samples. It was observed that swelling and drug release from hydrogels can be modified by changing composition and degree of cross-linking of the hydrogels... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Drugs/release; Hydrogels/pH sensitive; Polyvinylpyrrolidone-acrilic acid/hidrogels; Tramadol hydrochloride; Methylene bisacrylamide. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100018 |
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| Cheng,Zhongzhe; Xie,Ming; Zhang,Wenjie; Cheng,Lan; Du,Yang; Wang,Yunjiao; Ying,Xixiang; Kang,Tingguo. |
| The objective of the present study was to develop a simple and selective HPLC method for the simultaneous determination of hesperidin (HP), caffeic acid (CA), ferulic acid (FA) and p-coumaric acid (p-CA) in rat plasma after intravenous administration of Portulaca oleracea L. extract (POE). With the hyperoside as the internal standard, the sample pretreatment procedure involved simple single-step extraction with methanol of 0.2 mL plasma. The mobile phase consisted of methanol-acetonitrile-tetrahydrofuran-0.5% glacial acetic acid (5:3:18:74, v/v/v/v). The calibration curves were linear over the range of 0.1-25 µg mL-1, 0.1-25 µg mL-1, 0.1-25 µg mL-1and 0.015-3 µg mL-1 for HP, CA, FA and p-CA, respectively. The method developed was suitable for the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Portulaca oleracea L./pharmacognosy; High Performance Liquid Chromatography/rat plasma; Vegetal extract/pharmacokinetic study; Medicinal plants. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100018 |
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| Aiyalu,Rajasekaran; Govindarjan,Arulkumaran; Ramasamy,Arivukkarasu. |
| ABSTRACT The objective of the study is to formulate and evaluate a topical herbal gel containing Cardiospermum halicacabum and Vitex negundo leaf extracts for their anti-arthritic activity in rats. Twelve herbal gel formulations were prepared using 1.5% of gelling agents carbopol 934 (F1-F6) and carbopol 940 (F6-F12) and they were evaluated for physical appearance, net content, viscosity, extrudability, pH, spreadability, in vitro diffusion profile and primary skin irritation tests. The stability study for the topical herbal gel formulation was done as per ICH guidelines and anti-arthritic activity was evaluated by Freund's Complete Adjuvant (FCA) induced arthritis method. Assessment of body weight, paw volume, hematological and biochemical parameters,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Arthritis/treatment/herbal gel; Cardiospermum halicacabum/topical herbal gel; Vitex negundo/topical herbal gel; Medicinal plants/arthritis.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300493 |
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| Mercurio,Daiane Garcia; Calixto,Lívia Salomão; Campos,Patrícia Maria Berardo Gonçalves Maia. |
| Considering the importance of an adequate composition of the formulation in the development of stable, safe and effective cosmetic products, experimental design techniques are tools that can optimize the formulation development process. The objective of this study was to develop topical formulations using the Box-Behnken design with response surface methodology and evaluate its physical, sensory and moisturizing properties. The experimental design used in the first step allowed to identify and to quantify the influence of raw materials, as well as the interaction between them. In the second step, the analysis identified the influence of soy lecithin, the phytantriol and capric acid triglyceride and caprylic on the consistency index, stickiness and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Emulsions; Formulation; Stability; Skin barrier; Experimental design. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100624 |
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| Sousa,Sandra Alves de; Pascoa,Henrique; Conceição,Edemilson Cardoso da; Alves,Suzana Ferreira; Diniz,Danielle Guimarães Almeida; Paula,José Realino de; Bara,Maria Teresa Freitas. |
| "Guaraná" (Paullinia cupana) is used as a physical activity enhancer and stimulator due to its methylxanthines and condensed tannins. The aim of this work was to evaluate the dissolution behavior of five herbal medicines in the form of capsules and tablets containing guaraná. Assay and dissolution methods were validated and results obtained allowed simultaneous marker quantification with precision, accuracy, selectivity and robustness. Findings showed that 100% of the herbal medicinal products analyzed did not provide satisfactory results concerning the presence of four markers, 60% had three markers (caffeine, catechin and epicatechin), while 40% had only caffeine at tested dosage forms. In addition, after 30 minutes,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Herbal medicines/quality control; Herbal medicines/dissolution behavior; Medicinal plants; Guaraná/pharmacognosy; Paullinia cupana/pharmacognosy. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200008 |
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| Harwansh,Ranjit Kumar; Patra,Kartik Chandra; Pareta,Surendra Kumar; Singh,Jagadish; Rahman,Mohammed Akhlaquer. |
| The present investigation aims to evaluate an isotropic and thermodynamically stable nanoemulsion formulation for transdermal delivery of glycyrrhizin (GZ), with minimum surfactant and cosurfactant (Smix) concentrations that could improve its solubility, permeation enhancement, and stability. Pseudo-ternary phase diagrams were developed and various nanoemulsion formulations were prepared using soyabean oil as oil, Span 80, Brij 35 as a surfactant and isopropyl alcohol as a cosurfactant. Nanoemulsion formulations that passed the thermodynamic stability tests were characterized for pH, viscosity and droplet size using a transmission electron microscopy. The transdermal ability of glycyrrhizin through human cadaver skin was determined using Franz diffusion... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nanoemulsions/use; Nanoemulsions/in vitro skin permeation; Glycyrrhizin/transdermal delivery; Isotropic nanoemulsion formulation/evaluation; Anti-inflammatories/transdermal delivery; Surfactants; Permeation/enhancers; Permeation/in vitro study. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400014 |
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| Deschamps,Eleonora; Vasconcelos,Olivia; Lange,Lisete; Donnici,Claudio Luis; Silva,Merces Coelho da; Sales,Juliana Aparecida. |
| Today the management of solid waste and wastewater is a major concern for humanity. In the last decade, traces of pharmaceuticals have been reported in the water cycle and have raised concerns among regulators, water suppliers and the public regarding the potential risks to human health. This study evaluated solid waste management in the state of Minas Gerais and concluded that the main fate of hazardous waste has been incineration, while the non-hazardous waste has been recycled or sent to landfills. However, complaints to the Environmental Agency - FEAM have indicated that a significant number of companies just send their hazardous wastes to landfills or even to garbage dumps, thus highlighting the urgent need for adequate waste management in Minas... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pharmaceutical industry/management of waste; Solid waste/management; Solid waste/pharmaceutical industry; Waste water/management; Waste water/pharmaceutical industry; Brazil/pharmaceutical industry. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400017 |
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| Siafaka,Panoraia; Okur,Mehmet Evren; Ayla,Şule; Er,Sevda; Cağlar,Emre Şefik; Okur,Neslihan Üstündağ. |
| Inorganic and carbon based nanomaterials are widely used against several diseases, such as cancer, autoimmune diseases as well as fungi and bacteria colonization. In this work, Santa Barbara Amorphous mesoporous silica (SBA), Halloysite Nanotubes (HNTs) and Multiwalled Carbon Nanotubes (CNTs) were loaded with fluoroquinolone Levofloxacin (LVF) to be applied as antimicrobial agents. The prepared via adsorption nanocarriers were characterized by Fourier-Transformed Spectroscopy, Scanning Electron Microscopy as well as High Pressure liquid Chromatography. In vitro release studies were carried out using Simulated Body Fluid at 37oC and data analyzed by various kinetic models showing slow dissolution over 12-24 hours. Antimicrobial studies showed improved... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Carbon nanotubes; Santa barbara amorphous; Halloysite nanotubes; Levofloxacin; Toxicity; Antimicrobial. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100514 |
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| Tiwari,Ruchi; Srivastava,Birendra; Tiwari,Gaurav; Rai,Awanik. |
| The present study investigated a novel extended release system of promethazine hydrochloride (PHC) with acrylic polymers Eudragit RL100 and Eudragit S100 in different weight ratios (1:1 and 1: 5), and in combination (0.5+1.5), using freeze-drying and spray-drying techniques. Solid dispersions were characterized by Fourier-transformed infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), Nuclear magnetic resonance (NMR), Scanning electron microscopy (SEM), as well as solubility and in vitro dissolution studies in 0.1 N HCl (pH 1.2), double-distilled water and phosphate buffer (pH 7.4). Adsorption tests from drug solution to solid polymers were also performed. A selected solid dispersion system was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Promethazine hydrochloride/extended release; Drugs/extended release; Eudragit RL100; Eudragit S100; Acrylic polymers; Spray drying/pharmacotechnics; Freeze drying/pharmacotechnics; Extended realease/pharmacotechnics; Pharmaceutical formulations/evaluation. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400029 |
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| Registros recuperados: 1.286 | |
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