|
|
|
| Registros recuperados: 1.286 | |
|
|
| Funchal-Witzel,Maria Denise Ricetto; Castro,Lia Lusitana Cardozo de; Romano-Lieber,Nicolina Silvana; Narvai,Paulo Capel. |
| Brazilian scientific production on pharmaceutical care was identified based on articles indexed on the Medline, Embase, Lilacs, Web of Science and International Pharmaceutical Abstracts databases. Sixty-three articles published in both national and international journals were retrieved. With regard to authors, 72.3% were from the Southeast and South Regions, and 60.8% were affiliated to public universities. In relation to the type of studies, 85.7% were descriptive, and the most frequently researched fields were community pharmacies, hospitals and primary health care units. Articles were original in 65.1% of cases, updates in 20.6%, and reviews in 7.9%. An increase in publications commenced in 2006. In 31.7% of cases,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pharmaceutical care; Pharmaceutical assistance; Public health; Pharmaceutical services. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200023 |
| |
|
|
| Jing,Wu; Zhong,Jia; Ping,Liang Jian; Yan,Liu Hong. |
| ABSTRACT To study what kind of role uric acid play on the relationship between oxidative Stress and inflammation in peripheral and cerebral system of oxonate-induced hyperuricemic rats. Twenty-six eight male Wistar rats were divided into two groups randomly. Potassium oxonate was used to establish hyperuricemic model for four weeks. In 2nd and 4th week, uric acid (UA) level, total superoxide dismutase (T-SOD), Gu,Zn-SOD activity and interleukin-1beta (IL-1β) concentration in serum were determined respectively. In 4th week, one hour after last PO treatment, five rats of every group were given Evans Blue to test blood-brain barrier (BBB) permeability. Other brains were obtained to analysis T-SOD, Gu,Zn-SOD activity and IL-1β concentration in cerebral system.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hyperuricemic Blood brain barrier Potassium oxonate Oxidative stress Inflammatory Total-SOD Gu; Zn-SOD IL-1β Pathological injury. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400620 |
| |
|
| |
|
| |
|
|
| Sanches,Andréia Cristina Conegero; Correr,Cassyano Januário; Venson,Rafael; Gonçalves,Patrícia Rodrigues; Garcia,Mariana Martins; Piantavini,Mário Sérgio; Pontarolo,Roberto. |
| All patients with Diabetes Mellitus (DM) receive insulin therapy. In this study, we evaluated the efficacy, safety and tolerability of human insulin and insulin analogues. We performed a systematic review of the literature and a meta-analysis according to the Cochrane Collaboration methodology. In the absence of clinical studies comparing insulins, we performed a mixed treatment comparison to establish the differences between the active treatments. We included studies published from 1995 to 2010. HbA1c results, episodes of hypoglycemia and nocturnal hypoglycemia data were extracted and analyzed. Thirty-five randomized clinical trials were selected after examining the abstract and a full text review. These studies included 4,206 patients who received... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Insulins/meta-analysis; Diabetes mellitus/type 1; Insulin/treatment efficacy; Insulin/safety use. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300011 |
| |
|
|
| Zhang,Wenjie; Li,Di; Leng,Aijing; Ai,Junjun; Du,Yang; Meng,Yihan; Gao,Yucong; Ying,Xixiang. |
| The aim of the present study was to investigate the tissue distribution and excretion of five components of Portulaca oleracea L. extract (POE) in rat following oral administration. A rapid, sensitive and specific ultra-high performance liquid chromatography (UHPLC) method with puerarin as the internal standard was used for the quantitative analysis of five components of POE, including caffeic acid (CA), p-coumaric acid (p-CA), ferulic acid (FA), quercitrin (QUER) and hesperidin (HP) in rat tissues including the liver, intestine, stomach, muscle, heart, lung, brain, kidney and spleen, urine and feces. The results show that onlyp-CA and FA were found in nearly all tissues with low cumulative ratios, and CA was higher in the intestine and stomach with a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Portulaca oleracea L./pharmacokinetics; Portulaca oleracea L./extract/experimental study; Portulaca oleracea L./extract/ tissue distribution; Portulaca oleracea L./extrato/excretion; Compostos fenólicos; Ultra performance liquid chromatography/quantitative analysis. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300643 |
| |
|
|
| Munir,Bushra; Qadir,Abdul; Tahir,Mohammad. |
| ABSTRACT This study was conducted to find out the ameliorative properties of Tribulus terristeris L (TT) on BPA induced spermatotoxicity in male albino rats. Mature male albino rats were divided into five groups, Group A was taken as control for comparison group, whereas the other four groups namely B(vehicle control), C (toxic), D (preventive control) and Group E (amelioration group) received distilled water, olive oil, BPA, TT, and (TT + BPA) respectively. Macroscopic results revealed decreased body weight of rats, weight of testes, and the relative tissue weight index (RTWI) in BPA induced group. Hormonal (testosterone) assay results revealed the decreased values of BPA treated group. Microscopic examination of testis of BPA treated rats showed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bisphenol A/negative effects; Tribulus terristeris L./properties; Spermatotoxicity; Testosterone. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300611 |
| |
|
|
| Oliveira,Camila Freitas de; Oliveira,Vinicius Bednarczuk; Bobek,Vanessa Barbosa; Rech,Katlin Suellen; Betim,Fernando Cesar Martins; Dias,Josiane de Fatima Gaspari; Zanin,Sandra Maria Warumby; Miguel,Obdulio Gomes; Miguel,Marilis Dallarmi. |
| Psychotria fractistipula L.B.Sm, R.M. Klein & Delprete (Rubiaceae) is found in the existing Atlantic Forest in the South of Brazil, in the Paraná and Santa Catarina States. The members of Rubiaceae are characterized chemically by the presence of alkaloids, some pharmacological properties of which include antifungal, antibacterial, analgesic, antioxidant, antimutagenic, and antiviral activities. In this study, we report the results of anatomical, morphological, and histochemical analyses of the leaves and stems of the Rubiaceae family member, P. fractistipula. The anatomical analysis involved of light microscopy and scanning electron microscopy. Morpho-anatomical and histochemical characterization were made using standard methodology. The isolated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Psychotria; Morpho-anatomical; Phytochemistry. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100565 |
| |
|
|
| Nogueira,Raquel; Rego,Eliane Cristina Pires do; Sousa,Marcus Vinicius Barreto; Wollinger,Wagner; Silva,Thaís Elias da; Moreira,Gabriela Fernandes; Barin,Juliano Smanioto; Laporta,Luciane Varini; Mesko,Márcia Foster; Bittencourt,Celso Figueiredo; Rodrigues,Janaína Marques; Cunha,Valnei Smarçaro da. |
| This paper describes the studies performed with the candidate Certified Reference Material (CRM) of captopril, the first CRM of an active pharmaceutical ingredient (API) in Brazil, including determination of impurities (organic, inorganic and volatiles), homogeneity testing, short- and long-term stability studies, calculation of captopril content using the mass balance approach, and estimation of the associated measurement uncertainty. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Captopril/qualitative analysis; Medicines/Certified Reference Standards; Medicines/analytical quality control; High Pressure Liquid Chromatography (HPLC)/qualitative analysis; Medicines/contamination. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200015 |
| |
|
|
| Carreira,Raquel Linhares; Silva,Viviane Dias Medeiros; Januário,José Nélio; Aguiar,Marcos José Burle de; Starling,Ana Lúcia Pimenta; Silvestre,Marialice Pinto Coelho. |
| Visando ao preparo de farinha de trigo com baixo teor de fenilalanina (Phe), extraiu-se, enzimaticamente as proteínas, empregando-se uma protease alcalina de Bacillus licheniformis. Em seguida, os extratos protéicos foram hidrolisados pela ação de enzimas comerciais (pancreatina e bromelina) e de extratos enzimáticos obtidos da casca de abacaxi (bruto e purificado), avaliando-se alguns parâmetros enzimáticos, tais como tipo de enzima, tipo de ação enzimática, tipo de associação enzimática e ordem de ação enzimática. O carvão ativado (CA) foi empregado como meio adsorvente e a eficiência da remoção de Phe foi avaliada por espectrofotometria derivada segunda, determinando-se o teor de Phe na farinha de trigo e em seus hidrolisados, após tratamento com CA. O... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Farinha de trigo/preparo; Hidrolisados protéicos; Enzimas; Hidrólise enzimática; Protease alcalina; Fenilalanina/remoção; Carvão ativado/meio adsorvente. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000100011 |
| |
|
| |
|
| |
|
|
| Zam,Wissam. |
| ABSTRACT Recent findings in amino acid metabolism and the differences between normal, healthy cells and neoplastic cells have revealed that targeting single amino acid metabolic enzymes in cancer therapy is a promising strategy for the development of novel therapeutic agents. Arginine is derived from dietary protein intake, body protein breakdown, or endogenous de novo arginine production and several studies have revealed disturbances in its synthesis and metabolism which could enhance or inhibit tumor cell growth. Consequently, there has been an increased interest in the arginine-depleting enzymes and dietary deprivation of arginine and its precursors as a potential antineoplastic therapy. This review outlines the most recent advances in targeting... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Arginine-depleting enzyme/antineoplastic therapy; Dietary deprivation. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300402 |
| |
|
| |
|
| |
|
|
| Amaral,Gisele Ferreira; Dossa,Pietro Domingues; Viebig,Lígia Bocamino; Konno,Fabiana Toshie Camargo; Consoli,Amanda; Martins,Maria de Fátima Monteiro; Viani,Flávio Cesar; Bondan,Eduardo Fernandes. |
| ABSTRACT Pro-inflammatory cytokines and glial cells, especially microglial cells, have been implicated in persistent pain sensitization. Less is known about the role of astrocytes in pain regulation. This study aimed to observe the expression of the astrocytic biomarker glial fibrillary acidic protein (GFAP) and the serum levels of interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) after short-term administration of central pain relievers in rats not submitted to noxious stimuli. Male Wistar rats were divided into five groups, receiving for nine days- (1) amitriptyline (Amt-10 mg/kg/day, by gavage); (2) gabapentin (Gb-60 mg/kg/day, by gavage; (3) methadone (Me-4.5 mg/kg/day, intraperitoneal route [IP]); (4)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Neuropathic pain/treatment; Astrocytes/pain regulation; Analgesics/tests/treatment; Cytokines; Glial Fibrillary Acidic Protein/study. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400623 |
| |
|
|
| Botelho,Patrícia Borges; Fioratti,Cyntia Okoshi; Rogero,Marcelo Macedo; Barroso,Lucia Pereira; Bertolami,Marcelo Chiara; Castro,Inar Alves. |
| The objective of this study was to investigate whether differences in diet and in single-nucleotide polymorphisms (SNPs) found in paraoxonase-1 (PON-1), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), cholesterol ester transfer protein (CETP) and apolipoprotein E (APOE) genes, are associated with oxidative stress biomarkers and consequently with susceptibility of low-density cholesterol (LDL) to oxidation. A multivariate approach was applied to a group of 55 patients according to three biomarkers: plasma antioxidant activity, malondialdehyde and oxidized LDL (oxLDL) concentrations. Individuals classified in Cluster III showed the worst prognoses in terms of antioxidant activity and oxidative status. Individuals classified in Cluster I presented... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diet; Oxidative stress/biomarkers; Single-nucleotide polymorphism (SNPs); Lipoproteins/oxidation; Statins; Apolipoprotein E. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100005 |
| |
|
| |
|
| |
|
|
| Oliveira Junior,Haliton Alves de; Almeida,Alessandra Maciel; Acurcio,Francisco Assis; Santos,Jéssica Barreto dos; Kakehasi,Adriana Maria; Alvares,Juliana; Dabés,Clarice Gomes e Souza; Cherchiglia,Mariangela Leal. |
| The aim of this study was to describe the baseline demographic and clinical characteristics as well as the functional status of a prospective cohort of patients with rheumatic diseases assisted by the Brazilian Public Health System (SUS). Data for 302 patients receiving tumor necrosis factor α inhibitors (anti-TNF agents) was collected through a standard form. Among patients, 229 (75.8%) were female and 155 (51.3%) were Caucasian; the mean age was 50.3 ± 12.8 years, and the mean disease duration was 9.9 ± 8.7 years. Among them 214 patients (70.9%) received adalimumab, 72 (23.8%) etanercept, and 16 (5.3%) infliximab. Mean Health Assessment Questionnaire-Disability Index (HAQ-DI) was 1.37 ± 0.67 for all participants. Poor functional response was associated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rheumatic diseases/treatment/patients profile; Rheumatoid arthritis; Ankylosing spondylitis; Psoriatic arthritis; Brazilian public health system; Anti-TNF agents/treatment of rheumatic diseases. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300709 |
| |
| Registros recuperados: 1.286 | |
|
|
|
