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Effect of microalga Spirulina platensis (Arthrospira platensis) on hippocampus lipoperoxidation and lipid profile in rats with induced hypercholesterolemia BABT
Bertolin,Telma Elita; Pilatti,Dayane; Giacomini,Ana Cristina Vendrametto Varrone; Bavaresco,Caren Serra; Colla,Luciane Maria; Costa,Jorge Alberto Vieira.
Studies have been conducted on microalga Spirulina platensis (Arthrospira platensis) due to its therapeutic potential in several areas, including the capacity for preventing and decreasing the damages caused by hyperlipidemia and the antioxidant activity. The aim of the study was to evaluate the effect of microalga Spirulina platensis on hippocampus lipoperoxidation and lipid profile in rats with induced hypercholesterolemia during 60 days. The measurement of hippocampus lipoperoxidation did not demonstrate significant difference (p>0.05) when Spirulina platensis was added to hypercholesterolemic diet. The evaluation of lipid profile showed that the administration of the microalga in therapeutic and preventive ways led to a significant protective effect...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Spirulina; Arthrorspira; Lipids; Cholesterol; Antioxidant.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000500024
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Profile of milk fatty acids from moxotó goats fed with different levels of manicoba (Manihot Glaziovii Muel Arg.) silage BABT
Mesquita,Ítala Viviane Ubaldo; Costa,Roberto Germano; Queiroga,Rita de Cássia Ramos do Egypto; Medeiros,Ariosvaldo Nunes de; Schuler,Alexandre Ricardo Pereira.
The objective of this work was to evaluate the effects of the manicoba silage use (Manihot glaziovii Muel Arg.) in different roughage:concentrate ratios (30:70; 40:60; 50:50 and 60:40 %) on the fatty acids profile of the milk from Moxotó goats. Eight multiparous goats with approximately 60 post-birth days and weigh 44 kg on average were used in a Double Latin Square with four treatments, four periods and four animals. Each period lasted 15 days with 10 days of adaptation to experimental diets and 5 days of milk collection. The results of the fatty acids analyses were submitted to the analysis of variance (ANOVA) and regression. An increasing linear effect for the miristic acid (C14:0) and decreasing for the linoleic acid (C18:3) was observed in function of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nourishment; Lipids; Milk quality; Native breed.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000600011
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Effects of oral L-carnitine and DL-carnitine supplementation on alloxan-diabetic rats BABT
Bazotte,Roberto Barbosa; Lopes-Bertolini,Gisele.
The effect of oral L-carnitine (LC) or DL-carnitine (DLC) supplementation during one or four weeks (200 or 400 mg.kg-1.day-1) in diabetic rats was investigated. After the supplementation period, the blood was collected for the evaluation of total (TC) and free L-carnitine (FC), glucose, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triacylglycerol. Tissues were collected for the determination of TC and FC concentrations. The carnitine supplementation did not change levels of glucose, total cholesterol, HDL-C and LDL-C in the blood. Diabetic rats showed hypertriacylglycerolemia and decreased blood and tissue levels of FC and TC. Normalization of the blood triacylglycerol and increased blood...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carnitine; Diabetes; Dietary supplementation; Lipids; Rat.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000100010
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The effect of phosphoethanolamine intake on mortality and macrophage activity in mice with solid ehrlich tumors BABT
Arruda,Maria Sueli Parreira de; Correa,Mara Adriana; Venturini,James; Félix,Maira Camila; Rosis,Ana Maria Bormio De; Galhiane,Mário Sérgio; Chierice,Gilberto Orivaldo; Costa,Maria Renata Sales Nogueira.
The aim of the present study was to examine the effect of a diet rich in synthetic PEtn on the metabolism macrophages of tumor-bearing mice. The results demonstrated that PEtn increased the animals' survival time. In addition, the treated animals released smaller amounts of hydrogen peroxide (H2O2) and nitric oxide (NO) than the non-treated animals, particularly after day 14. From the results it could be concluded that H2O2 and NO were important in the modulation of neoplastic growth, and pointed to a promising role of PEtn in the control of human neoplasms.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phosphoethanolamine; Ehrlich tumor; Nitric oxide; Hydrogen peroxide; Lipids.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600016
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Sugar cane juice fermentation by Zymomonas mobilis CP4 subjected to inhibition by ethanol and high initial concentration of substrate BABT
Tano,Marcia S.; Buzato,João B.; Celligoi,Maria Antonia P. C..
Sugar cane juice fermentation by Z. mobilis CP4 subject to stress by ethanol and high concentration of sucrose was investigated. Supplementation with saponifiable portion of soybean oil deodourising destillate (SOD) at 5; 10 and 15 mL/L.The ethanol production resulted values of 15.91; 16.99 and 15.63 g/L respectively. Values of Yp/s 0.35; 0.36 and 0.37 were achieved, which represented 20.69; 24.14 and 27.59% respectively higher when unsupplemented medium fermentation was carried out.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Zymomonas mobilis; Fermentation; Lipids; Ethanol.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132000000400012
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Effects of fatty acids on carbohydrates and lipids of canola seeds during germination BABT
Ferrarese,M. L. L.; Baleroni,C. R. S.; Ferrarese-Filho,O..
The present work was carried out to investigate the effects of caprylic acid (C8) and oleic acid (C18) on carbohydrates and lipids during canola seed germination. The results showed that oleic acid influence carbohydrate concentration but did not influence lipid concentration. Significant results were found with caprylic acid that affected carbohydrates and lipids in cotyledons after three-day germination.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Allelochemicals; Carbohydrates; Lipids; Cotyledons; Canola.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89131998000300007
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Effects of moisture and extrusion temperatures on the oxidative stability of milling oat products with granularity below 532 µm BABT
Gutkoski,Luiz Carlos; El-Dash,Ahmed Atia.
The present research had as objective to study the effects of moisture and extrusion temperatures on the oxidative stability of oat fine (< 532 µm) milling products. The oat caryopsis were ground in a Brabender mill and separated in two fractions, coarse over 532 µm and fine less than 532 µm. The fine fraction, with higher amount of starch and low amount of crude protein, lipids and dietary fiber content when compared to oat coarse milling products was conditioned to moisture levels (15.5-25.5 %) and extruded in a simple one-screw Brabender laboratory extruder (C/D= 20:1). The conditions of extrusion were compression ratio 3:1, screw speed of 100 rpm, a die of 6 mm in diameter and temperatures between 77.6 and 162.4 ºC in the 2nd and 3rd zones while the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Avena sativa; Lipids; Peroxide; N-hexanal.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89131998000400003
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Influence of integral and decaffeinated coffee brews on metabolic parameters of rats fed with hiperlipidemic diets BABT
Gomes,Júlia Ariana de Souza; Faria,Bruno Generoso; Silva,Viviam de Oliveira; Zangerônimo,Márcio Gilberto; Miranda,José Rafael; Lima,Adriene Ribeiro de; Pereira,Rosemary Gualberto Fonseca Alvarenga; Pereira,Luciano José.
The objective of this study was to evaluate the influence of integral and decaffeinated coffee brews (Coffea arabica L and C. canephora Pierre) on the metabolic parameters of rats fed with hyperlipidemic diet. Thirty male Wistar rats (initial weight of 270 g ± 20 g) were used in the study, which were divided into six groups five each. The treatments were normal diet, hyperlipidemic diet, hyperlipidemic diet associated with integral coffee arabica or canephora brews (7.2 mL/kg/day) and hyperlipidemic diet associated to decaffeinated arabica, or canephora brews, using the same dosage. After 41 days, performance analyses were conducted.The rats were then euthanized and the carcasses were used for the analysis of dried ether extract and crude protein....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lipids; Adipocytes; Hyperlipidemia; Caffeine; Decaffeination.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000500015
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Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate BJID
Caramelli,Bruno; Bernoche,Claudia Y.S.M. de; Sartori,Ana M. C.; Sposito,Andrei C.; Santos,Raul D.; Monachini,Maristela C.; Strabelli,Tania; Uip,Davi.
Hyperlipidemia has been frequently recorded as a side effect of treating HIV patients with protease inhibitors (PI). This study was initiated to analyze the modifications on blood lipids in HIV-patients receiving PI and the safety and efficacy of the treatment with fenofibrate. Total (TC) and HDL-cholesterol, triglycerides (TG), and CD4+ T-cell counts were measured in 30 HAART-naive patients (Group I) before and after PI introduction. In a second phase of the study, the effects of fenofibrate on lipids, CPK, CD4+, and viral load were determined in 13 patients (Group II) with elevated TC or TG. In Group I, 60% of the patients showed TC or TG elevations. Average increments of 31% and 146% in TC and TG respectively (p<0.0006 and p<0.0001) were observed....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cholesterol; Lipids; HIV infection; Triglycerides.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600007
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Effect of Camellia sinensis teas on left ventricular hypertrophy and insulin resistance in dyslipidemic mice BJMBR
Ferreira,M.C.L.; Lima,L.N.; Cota,L.H.T.; Costa,M.B.; Orsi,P.M.E.; Espíndola,R.P.; Albanez,A.V.; Rosa,B.B.; Carvalho,M.G.S.; Garcia,J.A.D..
The control of dyslipidemia using plants is an important subject of studies since it has numerous benefits in cardiovascular protection. The objective of this study was to evaluate the effect of three Camellia sinensis L. teas (green, red, and white) on left ventricular hypertrophy and insulin resistance in low-density lipoprotein receptor knockout (LDLr-/-) mice fed a high-fat diet. The LDLr-/- mice were divided into four experimental groups: Group C: standard feed; Group CT: standard feed and three teas, Group HL: high-fat feed; HLT Group: high-fat feed and three teas. The three types of tea (green, red, and white) originated from different processing of the Camellia sinensis L. plant, and were administered associated once a day at a dose of 25 mg/kg by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lipids; Cardiovascular system; Tea; Glucose; Insulin.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000500607
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Apolipoprotein B and angiotensin-converting enzyme polymorphisms and aerobic interval training: randomized controlled trial in coronary artery disease patients BJMBR
Tamburus,N.Y.; Verlengia,R.; Kunz,V.C.; César,M.C.; Silva,E..
Physical training has been strongly recommended as a non-pharmacological treatment for coronary artery disease (CAD). Genetic polymorphisms have been studied to understand the biological variability in response to exercise among individuals. This study aimed to verify the possible influence of apolipoprotein B (ApoB: rs1042031 and rs693) and angiotensin-converting enzyme (ACE-ID: rs1799752) genotypes on the lipid profile and functional aerobic capacity, respectively, after an aerobic interval training (AIT) program in patients with CAD and/or cardiovascular risk factors. Sixty-six men were randomized and assigned to trained group (n=32) or control group (n=34). Cardiopulmonary exercise test was performed to determine the ventilatory anaerobic threshold...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Physical training; Lipids; Apolipoprotein B polymorphism; Angiotensin-converting enzyme polymorphism; Aerobic capacity.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000800601
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Effect of FSH and insulin on lipogenesis in cultures of Sertoli cells from immature rats BJMBR
Follicle-stimulating hormone (FSH) and insulin regulate glycide metabolism in Sertoli cells, thus stimulating lactate production. These stimulatory effects of FSH and insulin do not require protein synthesis, suggesting a modulation of enzyme activity and/or regulation of glucose transport. The present investigation was performed to characterize the hormonal control of lipid metabolism in Sertoli cells. The data indicate that FSH and insulin have a regulatory effect on lipid metabolism in Sertoli cells. After 8 h of preincubation with insulin (5 µg/ml), the activity of the enzyme ATP-citrate lyase in cultured Sertoli cells was increased from 0.19 to 0.34 nmol NAD+ formed µg protein-1 min-1. FSH (100 ng/ml) had no effect on this enzyme. Glycerol phosphate...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Sertoli cells; Lipids; FSH; Insulin.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000500004
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Effects of dietary lipids on renal function of aged rats BJMBR
Valente Gamba,C.; Zeraib Caraviello,A.; Matsushita,A.; Alves,G.M.; Nunes da Silva,L.; Nascimento Gomes,G.; Zaladek Gil,F..
Normal aging is accompanied by renal functional and morphological deterioration and dietetic manipulation has been used to delay this age-related decline. We examined the effects of chronic administration of diets containing 5% lipid-enriched diet (LD, w/w) on renal function of rats at different ages. Three types of LD were tested: canola oil, fish oil and butter. Mean systemic tail-cuff blood pressure and glycemia remained within the normal range whatever the age and the diet of the animals. Proteinuria began to rise from the 8th month in the groups ingesting LD, while in the control group it increased significantly (above 10 mg/24 h) only after the 10th month. With age, a significant and progressive decline in glomerular filtration rate (GFR) and renal...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Aging; Lipids; Proteinuria; Renal function; Acid excretion; Canola oil; Fish oil.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200016
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Chronic postnatal administration of methylmalonic acid provokes a decrease of myelin content and ganglioside N-acetylneuraminic acid concentration in cerebrum of young rats BJMBR
Brusque,A.M.; Rotta,L.; Pettenuzzo,L.F.; Junqueira,D.; Schwarzbold,C.V.; Wyse,A.T.; Wannmacher,C.M.D.; Dutra-Filho,C.S.; Wajner,M..
Levels of methylmalonic acid (MMA) comparable to those of human methylmalonic acidemia were achieved in blood (2-2.5 mmol/l) and brain (1.35 µmol/g) of rats by administering buffered MMA, pH 7.4, subcutaneously twice a day from the 5th to the 28th day of life. MMA doses ranged from 0.76 to 1.67 µmol/g as a function of animal age. Control rats were treated with saline in the same volumes. The animals were sacrificed by decapitation on the 28th day of age. Blood was taken and the brain was rapidly removed. Medulla, pons, the olfactory lobes and cerebellum were discarded and the rest of the brain ("cerebrum") was isolated. Body and "cerebrum" weight were measured, as well as the cholesterol and triglyceride concentrations in blood and the content of myelin,...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Methylmalonic acid; Glycerides; Lipids; Myelin; Rat brain; Methylmalonic acidemia.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200010
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Apolipoprotein E polymorphism in Brazilian dyslipidemic individuals: Ouro Preto study BJMBR
Mendes-Lana,A.; Pena,G.G.; Freitas,S.N.; Lima,A.A.; Nicolato,R.L.C.; Nascimento-Neto,R.M.; Machado-Coelho,G.L.L.; Freitas,R.N..
The influence of apolipoprotein E alleles and genotypes on plasma lipid levels was determined in 185 individuals of mixed ethnicity living in Ouro Preto, Brazil. DNA was obtained from blood samples and the genotypes were determined by an RFLP-PCR procedure. The *3 allele was the most frequent (72%), followed by *4 (20%) and *2 (8%); *4 frequency was higher and *2 frequency was lower in the dyslipidemic group than in the normal control group. The *2 carriers presented lower LDL and total cholesterol levels compared to the *3 and *4 carriers. All six expected genotypes were observed in the individuals genotyped: E2/2 (2.1%), E4/4 (2.7%), E2/4 (3.7%), E2/3 (8.0%), E3/3 (53.3%), E3/4 (29.9%); no difference in genotype frequencies was found between the normal...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Apolipoprotein E polymorphism; Lipids; Dyslipidemia; Brazilian population; Atherosclerosis.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100007
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Effect of dietary fat saturation on lipid metabolism, arachidonic acid turnover and peritoneal macrophage oxidative stress in mice BJMBR
Oliveros,L.B.; Videla,A.M.; Giménez,M.S..
We investigated the effects of a saturated fat diet on lipid metabolism and arachidonic acid (AA) turnover in mouse resident peritoneal macrophages. The pro-oxidative effect of this diet was also studied. Female C57BL/6 mice were weaned at 21 days of age and assigned to either the experimental diet containing coconut oil (COCO diet), or the control diet containing soybean oil as fat source (10 mice per group). The fat content of each diet was 15% (w/w). Mice were fed for 6 weeks and then sacrificed. The concentration of total lipids, triglycerides, (LDL + VLDL)-cholesterol, thiobarbituric acid-reactive substances (TBARS) and reduced glutathione were increased in the plasma of mice fed the COCO diet, without changes in phospholipid or total cholesterol...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Peritoneal macrophage; Coconut oil; Soybean oil; Lipids; Oxidative stress; Arachidonic acid.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000300004
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Atherogenic lipid profile of Brazilian near-term newborns BJMBR
Pardo,I.M.C.G.; Geloneze,B.; Tambascia,M.A.; Barros-Filho,A.A..
Cardiovascular disease is the primary cause of death in Brazil. Recent studies have shown that low birth weight and preterm birth are linked to a higher prevalence of cardiovascular disease. The aim of the present study was to compare the levels of lipids and apolipoproteins and atherogenic indexes between term and near-term newborn infants. A sample of umbilical cord blood was obtained from 135 newborns (66 males) divided into two groups: 25 near-term neonates (35-36.6 weeks of gestational age) and 110 term neonates (37-42 weeks of gestational age). The total cholesterol concentrations were higher in the near-term neonates than in the term group (94.04 ± 8.02 vs 70.42 ± 1.63 mg/dl, P < 0.01), due to an increase in the LDL-cholesterol fraction in the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lipids; Apolipoproteins; Cholesterol; Cord blood; Cardiovascular disease; Newborns.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500013
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Inhibition of rat microsomal lipid peroxidation by the oral administration of D002 BJMBR
Menéndez,R.; Amor,A.M.; González,R.M.; Jiménez,S.; Más,R..
The effect of D002, a defined mixture of higher primary alcohols purified from bee wax, on in vivo and in vitro lipid peroxidation was studied. The extent of lipid peroxidation was measured on the basis of the levels of thiobarbituric acid reactive substances (TBARS). When D002 (5-100 mg/kg body weight) was administered orally to rats for two weeks, a partial inhibition of the in vitro enzymatic and non-enzymatic lipid peroxidation was observed in liver and brain microsomes. Maximal protection (46%) occurred at a dose of 25 mg/kg. D002 behaved differently depending on both the presence of NADPH and the integrity of liver microsomes, which suggests that under conditions where microsomal metabolism was favored the protective effect of D002 was increased....
Tipo: Info:eu-repo/semantics/article Palavras-chave: D002; Higher aliphatic alcohols; Microsomes; Lipids; Peroxidation.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100012
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Monounsaturated fats and immune function BJMBR
Yaqoob,P..
Animal studies suggest that olive oil is capable of modulating functions of cells of the immune system in a manner similar to, albeit weaker than, fish oils. There is some evidence that the effects of olive oil on immune function in animal studies are due to oleic acid rather than to trace elements or antioxidants. Importantly, several studies have demonstrated effects of oleic acid-containing diets on in vivo immune responses. In contrast, consumption of a monounsaturated fatty acid (MUFA)-rich diet by humans does not appear to bring about a general suppression of immune cell functions. The effects of this diet in humans are limited to decreasing aspects of adhesion of peripheral blood mononuclear cells, although there are trends towards decreases in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fatty acids; Lipids; Immunity; Olive oil; Adhesion molecules.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400001
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Proteoliposomes as matrix vesicles' biomimetics to study the initiation of skeletal mineralization BJMBR
Simão,A.M.S.; Yadav,M.C.; Ciancaglini,P.; Millán,J.L..
During the process of endochondral bone formation, chondrocytes and osteoblasts mineralize their extracellular matrix by promoting the formation of hydroxyapatite (HA) seed crystals in the sheltered interior of membrane-limited matrix vesicles (MVs). Ion transporters control the availability of phosphate and calcium needed for HA deposition. The lipidic microenvironment in which MV-associated enzymes and transporters function plays a crucial physiological role and must be taken into account when attempting to elucidate their interplay during the initiation of biomineralization. In this short mini-review, we discuss the potential use of proteoliposome systems as chondrocyte- and osteoblast-derived MVs biomimetics, as a means of reconstituting a phospholipid...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Alkaline phosphatase; Biomineralization; Calcification; Lipids; Pyrophosphate; ATP.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000300003
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