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Registros recuperados: 128
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Detection of Mycoplasma pulmonis in laboratory rats BJM
Barreto,Maria Lucia; Nascimento,Elmiro Rosendo do; Campos,Carlos Augusto de Martino; Nascimento,Maria da Graça Fichel do; Lignon,Gilberto Brasil; Lira,Marie Luce Flores; Silva,Ricardo G..
This work was conducted on rats in two premises located in Niterói and Rio de Janeiro, Brazil. One is classified as conventional controlled and the other, conventional. The objective of the present study was to detect the presence of Mycoplasma pulmonis in animals with symptoms of respiratory disease and low reproductive performance. In the conventional controlled premises, 16 rats of Wistar-Furth strain were necropsied while in the conventional premises necropsy was performed on 12 rats of Hooded Lister strain. The clinical samples of lungs, trachea, oropharynx, middle ear, uterus and ovaries were subjected to culturing while the sera were tested for antibody detection. From 28 rats, 57.14% (16/28) were culture positive for M. pulmonis, being 81.25%...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mycoplasma pulmonis; Diagnosis; Isolation; Serology; Rats.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000300015
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Metabolic analysis of the effect of rheum on a taurocholate-induced acute pancreatitis rat model BJPS
Chen,Zhonghua; Shen,Li; Yang,Changyong; Jiang,Jinghui; Liu,Xing.
ABSTRACT The effects of rheum on serum parameters in a taurocholate-induced acute pancreatitis (AP) rat model were investigated using pathological and biochemical tests, and a proton nuclear magnetic resonance (1H NMR)-based metabonomic strategy. Healthy rats and rats with AP were either treated with rheum (7.5% at a dose of 1.5 g/kg) or left untreated. Serum samples were collected from the AP and rheum-treated groups at 6, 12, and 24 h after treatment. The effect of rheum on pathological changes in the pancreatic was investigated to validate the AP model. We obtained 1H NMR spectra and analyzed the results using the partial least squares discriminant method. The results of the pathological and metabolic analyses revealed an amelioration of multiple...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rheum/effects; Acute pancreatitis/analysis; Metabolomics; 1H NMR; Pathological changes; Rats.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200633
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Modulatory effect of baicalein on gene expression and activity of antioxidant enzymes in streptozotocin-nicotinamide induced diabetic rats BJPS
Sarkar,Purabi; Nath,Kaberi; Banu,Sofia.
Oxidative stress plays the central role in the pathogenesis and progression of diabetic complications. The present study aims to investigate the beneficial effect of oral administration of flavone baicalein in streptozotocin-nicotinamide (STZ-NA) induced diabetic rats by measuring oxidative stress markers, antioxidant enzyme activities and expression analysis of antioxidant genes. Experimental diabetes was induced by a single intraperitoneal (i.p.) injection of STZ (55 mg /kg b.wt), 15 min after the i.p. administration of NA. At the end of the experimental period, thiobarbituric acid reactive substances (TBARS), activities of antioxidant enzymes and expression levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; Streptozotocin/pharmacology; Baicalein/pharmacology; Nicotinamide/pharmacology; Glibenclamide; Diabetes Mellitus/ Experimental/prevention and control; Gene Expression/drug effects; Antioxidants/pharmacology; Glyburide/pharmacology; Rats.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100508
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Pre- and postnatal evaluation of offspring rats exposed to Origanum vulgare essential oil during mating, gestation and lactation Ciência Rural
Hollenbach,Clarissa Boemler; Stedile,Rafael; Mello,Fabíola Peixoto da Silva; Bing,Rafaela Scheer; Rosa,Patrícia Pisoni da; Rodrigues,Maria Regina Alves; Mello,Fernanda Bastos de; Zanette,Régis Adriel; Mello,João Roberto Braga de.
ABSTRACT: Despite the increasing use of oregano ( Origanum vulgare L.) essential oil for therapeutic purposes, pre- and postnatal development of animals offspring exposed to this oil has not yet been evaluated. In line with previous concerns of genotoxicity, in this study adult rats were exposed to different doses of oregano essential oil (3, 9 and 27% vol/vol) during pre-mating, mating, gestation and lactation. Prenatal screening included fetal development and uterine inspection, where the reproductive rate of females such as breeding, pregnancy, delivery, viability and post-implantation loss rate were measured. Postnatal evaluation of rat offspring included motor development, neuroendocrine and behavioral assessment. Body weight of rat dams and signs of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Oregano; Reproductive toxicity; Progeny; Reproduction; Rats.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000100552
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Could mesenchymal stem cell therapy help in the treatment of muscle damage caused by Bothrops alternatus venom? Ciência Rural
Telles,Thalita da Costa; Botelho,Ana Flávia Machado; Miranda,Ana Luisa Soares de; Soto-Blanco,Benito; Serakides,Rogéria; Ocarino,Natália de Melo; Melo,Marília Martins.
ABSTRACT: The aim of this study was to evaluate the use of mesenchymal stem cells (MSC) in the treatment of myonecrosis induced by Bothrops alternatus venom in rats. Seventy-five male adult Wistar rats were divided into three experimental groups. G1 and G2 were injected in the gastrocnemius muscle with 120μg of B. alternatus venom, while G3 received 200μL of PBS only. Three days after the venom injection, 12 rats from G1 were treated with 5.0 x 106 MSC in PBS, whereas G2 and G3 rats received PBS. Every three days, blood and muscle samples of five animals from each group were taken for serum biochemical and pathological analyses. Histological examinations showed more intense muscle lesions following MSC treatment, characterized by disorganization and loss...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Viperidae envenomation; Stem cells; Rats; Myonecrosis; Muscular repair.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000300602
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Effect of acupuncture on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats Ciência Rural
Scognamillo-Szabó,Márcia Valéria Rizzo; Bechara,Gervásio Henrique; Cunha,Fernando de Queiroz.
Acupuncture is an ancient and empirical therapeutic procedure known by its efficacy in the treatment of pain. However, the influence of acupuncture on inflammatory process is still poorly understood and additional research is needed. In this work, we investigated the mechanism of action of manual acupuncture on the inhibition of neutrophil migration to the peritoneal cavity induced by the inflammatory stimulus carrageenan in Wistar rats. Previous results from our laboratory showed that this anti-inflammatory effect is not due to endogenous corticoid release. Furthermore, the concentration of IL-<FONT FACE=Symbol>1b</FONT>, but not of TNF-alpha or IL-10 in the carrageenan-induced exudates was reduced in the acupuncture group. Further research...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acupuncture; Inflammation; Cytokines; Neutrophils; Rats; Carrageenan.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782005000100016
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Persistent papillary membrane in Wistar laboratory rats ( Rattus Norvegicus, Albinus Variation, Wistar ) Ciência Rural
Chacaltana,Flor Diana Yokoay Claros; Kobashigawa,Karina Kamachi; Padua,Ivan Ricardo Martinez; Valdetaro,Gisele Pereira; Aldrovani,Marcela; Laus,José Luiz.
ABSTRACT: The aim of this research was to evaluate the presence of persistent pupillary membrane (PPM) in rats. Thirty rats between three and four months of age and weighing 300-500 grams, provided by the biothery section of the General Administration at Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil, were subjected to ophthalmological examination by slit lamp biomicroscopy, fluorescein eye stain test and rebound tonometry. We found PPM with possible hereditary origin in 15 animals (50%).
Tipo: Info:eu-repo/semantics/article Palavras-chave: Persistent pupillary membrane; Wistar; Rats.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000300602
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Amylose content in rice (Oryza sativa) affects performance, glycemic and lipidic metabolism in rats Ciência Rural
Denardin,Cristiane Casagrande; Boufleur,Nardeli; Reckziegel,Patrícia; Silva,Leila Picolli da; Walter,Melissa.
This research aimed at evaluating the effect of diets with high, intermediate and low amylose content of rice on performance, glycemic and lipidic metabolism in rats. Male Wistar rats were fed diets with grains of cooked rice of the cultivars 'IRGA 417', 'IRGA 416' and 'MOCHI' with high, intermediate and low amylose content, respectively. Wet and dry fecal production and serum HDL cholesterol were not affected by amylose content. The animals in the treatments with high amylose content ('IRGA 417') presented lower feed intake, body weight gain and apparent digestibility, higher fecal water content and nitrogen excretion, reduced fecal pH, lower postprandial blood glucose response, serum total cholesterol and triglycerides levels and pancreas weight, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rice grains; Hyperglycemia; Metabolic responses; Rats.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782012000200030
Registros recuperados: 128
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