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| Registros recuperados: 3.453 | |
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| UnCheol Lee; Seunghwan Kim; Gyu-Jeong Noh; Byung-Moon Choi; George A. Mashour. |
| The cognitive unbinding paradigm suggests that the synthesis of cognitive information is attenuated by general anesthesia. Here, we investigated the functional organization of brain activities in the conscious and anesthetized states, based on characteristic functional segregation and integration of electroencephalography (EEG). EEG recordings were obtained from 14 subjects undergoing induction of general anesthesia with propofol. We quantified changes in mean information integration capacity in each band of the EEG. After induction with propofol, mean information integration capacity was reduced most prominently in the gamma band of the EEG (p=0.0001). Furthermore, we demonstrate that loss of consciousness is reflected by the breakdown of the... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1244/version/2 |
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| Valentin Mitin. |
| Any human organism is home to viruses and bacteria. However, viruses (as well as other intracellular parasites) are interested in continuous division of the host cells. Unlimited division of the host cells means unlimited expansion of the living space and possibility for unlimited multiplication of viral particles. For this, human Cell Cycle Regulation System has to be affected in such a way to induce unlimited division of host cells. The present work describes oncogenome`s model of cancer development, according to which, in order to stimulate cell division, viruses affect a gene (or several genes) during transduction of a signal for cell division from growth factor to cyclin/CDK system. At the same time, controlling gene (p53, RB etc.) function and a... |
| Tipo: Manuscript |
Palavras-chave: Cancer. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6322/version/1 |
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| Luke McCarthy; Ben Vandervalk; Mark D. Wilkinson. |
| SPARQL query composition is difficult for the lay-person or even the experienced bioinformatician in cases where the data model is unfamiliar. Established best-practices and internationalization concerns dictate that semantic web ontologies should use terms with opaque identifiers, further complicating the task. We present SPARQL Assist: a web application that addresses these issues by providing context-sensitive type-ahead completion to existing web forms. Ontological terms are suggested using their labels and descriptions, leveraging existing XML support for internationalization and language-neutrality. |
| Tipo: Presentation |
Palavras-chave: Bioinformatics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5382/version/1 |
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| Sebastian Bassi; Virginia Gonzalez. |
| Checksum algorithms are used in biological databases for integrity check and identification purposes. CRC64 is the only checksum algorithm already included in Biopython. This work proposes two new implementation of known algorithms (GCG Checksum and SEGUID). There is also an application based on SEGUID: Looking for redundancy between two FASTA files full of protein sequences based only in sequence information, by comparing the SEGUIDs of both files.
The code is shown in the manuscript and may be available at Biopython.org. |
| Tipo: Presentation |
Palavras-chave: Bioinformatics. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/278/version/1 |
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| Julijana Gjorgjieva; Michael Famulare; Rebecca Mease; William J. Moody; Adrienne L. Fairhall. |
| Summary: 

Many neural systems are equipped with mechanisms to efficiently encode sensory information. To represent natural stimuli with time-varying statistical properties, neural systems should adjust their gain to the inputs' statistical distribution. Such matching of dynamic range to input statistics has been shown to maximize the information transmitted by the output spike trains (Brenner et al., 2000, Fairhall et al., 2001). Gain scaling has not only been observed as a system response property, but also in single neurons in developing somatosensory cortex stimulated with currents of different amplitude (Mease et al., 2010). While gain scaling holds for cortical neurons at the end of the first post-natal... |
| Tipo: Poster |
Palavras-chave: Neuroscience. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5860/version/1 |
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| Giovanni Ferrari; B D. Cook; Vitaly Terushkin; Giuseppe Pintucci; Paolo Mignatti. |
| VEGF and TGF-[beta]1 induce angiogenesis but have opposing effects on endothelial cells. VEGF protects endothelial cells from apoptosis; TGF-[beta]1 induces apoptosis. We have previously shown that VEGF / VEGF receptor-2 (flk-1) signaling mediates TGF-[beta]1 induction of apoptosis. This finding raised an important question: Does this mechanism stimulate or inhibit angiogenesis? Here we report that VEGF-mediated apoptosis is required for TGF-[beta]1 induction of angiogenesis. In vitro the apoptotic effect of TGF-[beta]1 on endothelial cells is rapid and followed by a long period in which the cells are refractory to apoptosis induction by TGF-[beta]1. Inhibition of VEGF / flk-1 signaling abrogates formation of vessel-like structures by TGF-[beta]1 with an... |
| Tipo: Manuscript |
Palavras-chave: Cancer. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1758/version/1 |
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| Maria Vladimirtseva; Inga Bysykatova; Sergey Sleptsov. |
| We researched the ecology of the third rarest crane species, Siberian crane, which breeds in northern-eastern Siberian tundra. Nesting in places near great lakes, this crane appears to be an indicator of the global warming processes that affect lake growth as a result of the permafrost situation close to the surface in tundra. Research has shown that these birds are presumably fish-eating during their incubation period, coinciding with the flooding season when fish come to areas around great lakes. Such a diet may be explained by the necessity of high-energy food during the incubating period as well as the particularity of this species for leaving plant resources around the nest point for the period of the first days after chick hatching. This situation... |
| Tipo: Manuscript |
Palavras-chave: Ecology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6997/version/1 |
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| Jeni Chandar Padua; Basil Rose MR. |
| Radiation exposure during gestation causes mutation in the fetus leading to birth defects in the newborn. On a survey of the coastal villages of Kanyakumari District, Tamilnadu, India, high levels of background radiation were detected, which was suggestive of inducing mutations, and congenital abnormalities in the exposed population. To substantiate the dangerous impact of such natural radioactive emissions, we have established an avian model of irradiation-induced birth defect in chicks hatched from eggs exposed to natural radioactive beach sand. The hatched experimental chicks exhibited severe locomotor disability and extreme malformations. Our study proves for the first time, that natural beach sand radiation induces severe developmental abnormalities.... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Earth & Environment. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6191/version/1 |
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| Ajay Jasra; Thomas A. Dean; Sumeetpal S. Simgh; Gareth W. Peters. |
| In this talk I consider sequential Monte Carlo (SMC) methods for hidden Markov models. In the scenario for which the conditional density of the observations given the latent state is intractable we give a simple ABC approximation of the model along with some basic SMC algorithms for sampling from the associated filtering distribution. Then, we consider the problem of smoothing, given access to a batch data set. We present a simulation technique which combines forward only smoothing (Del Moral et al, 2011) and particle Markov chain Monte Carlo (Andrieu et al 2010), for an algorithm which scales linearly in the number of particles. |
| Tipo: Presentation |
Palavras-chave: Evolutionary Biology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5957/version/1 |
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| Victor H. Han; Gilles Lajoie; Jennifer Ballard; Aaron Booy; Nicholas Carruthers; Delfina Siroen. |
| Preeclampsia is a pregnancy-associated disorder that manifests as a sudden increase in maternal blood pressure accompanied by proteinuria. Because the placenta is a key organ in preeclampsia, we used proteomic and lipidomic analyses to compare placentae from preeclamptic and gestational age matched control pregnancies. Fatty acid binding protein 4 (FABP4), enoyl-CoA dehydrogenase and delta-3,5-delta-2,4-dienoyl-CoA isomerase had altered abundance in preeclamptic placentae compared to controls. FABP4 placental protein and RNA and plasma levels were all increased in early-onset preeclampsia (prior to 28 weeks gestation) compared to controls (6-fold, 3.3-fold and 3.5-fold respectively). After 28 weeks, FABP4 protein in control placenta and plasma increased to... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Genetics & Genomics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4885/version/1 |
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| Wei Sheng Zeng; Shou Zheng Tang. |
| To implement monitoring and assessment of national forest biomass, it is becoming the trend to develop generalized single-tree biomass models suitable for large scale forest biomass estimation. Considering that the theoretical biomass allometric model developed by West et al. [1,2] was statistically different from the empirical one, the two parameters in the most commonly used biomass equation M=aDb were analyzed in this paper. Firstly, based on the knowledge of geometry, the theoretical value of parameter b was deduced, i.e., b=7/3(≈2.33), and the comparison with many empirical studies conducted throughout the globe indicated that the theoretical parameter could describe soundly the average allometric relationship between aboveground biomass M... |
| Tipo: Manuscript |
Palavras-chave: Ecology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6704/version/1 |
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| Bernt C. Skottun; John R. Skoyles. |
| Conlon at al. (2011, Brain and Cognition, 76, 197-205) studied the responses of dyslexic readers and controls to rapidly presented stimuli. They found that the dyslexic readers showed poorer performance than the controls but only when the interstimulus interval (ISI) was short (150 ms), not when it was long (350 ms). This difference they attributed to a magnocellular or dorsal stream deficiency. However, they did not compute the temporal frequency spectra of the two stimuli. This is done here. It is found that it is very difficult to draw any conclusions with regard to the magnocellular system or the dorsal stream using these stimuli. |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6050/version/1 |
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| Loris Grossi. |
| The hydrogen sulfide has been recently claimed to have an important role in the cardiovascular system, as well in the central nervous system, but its action seems directly connected to the presence of NO/NO-derivatives. We want to report here chemical evidences that suggest for the H2S a role as a cofactor, able to induce NO release from NO-donors, more than a direct neurotransmitter. |
| Tipo: Manuscript |
Palavras-chave: Chemistry; Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2026/version/1 |
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| Bin-Guang Ma. |
| The emergence of “Systems Biology” in recent years highlights the systematic viewpoint of bio-system modeling. Building on such a background, Dual Descriptor Method, a generic methodology for biological sequence analysis is proposed. From a systematic perspective, Dual Descriptor is defined as a two element set of Composition Weight Map and Position Weight Function which aim at reflecting the composition and permutation information of a sequence. An alternate training algorithm is provided to get an optimum description of the building patterns of the sequences. In this paper, dual descriptor method has been applied to the analysis of two typical problems of molecular biology: gene identification and the prediction of protein function.... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2223/version/1 |
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| Amjesh R; Achuthsankar S. Nair; Sugunan V.S.. |
| Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality. To date there is no effective drug for the treatment or vaccine to prevent this infection. The present study aims to discover novel inhibitors which target an allosteric binding site of RNA dependent RNA polymerase enzyme of HCV. A structure based virtual screening of Zinc database by computational docking and the post docking analysis of energy calculations and interactions followed by ADMET studies were conducted. Our study revealed 10 compounds which has more potential than the existing inhibitor to be considered as lead compounds.
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| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/7055/version/1 |
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| Registros recuperados: 3.453 | |
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