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Ploidy influences on metabolic substrate deposition of rainbow trout Animal Sciences
Gomes, Aline Dal`Olio; Vieira, Vanessa Aparecida Rocha Oliveira; Tabata, Yara Aiko; Takahashi, Neuza Sumico; Moreira, Renata Guimarães; Ribeiro, Cristiele Silva.
Triploid fish are usually sterile. Thus, the energy and nutrients intended for sexual maturation may be available to enhance flesh quality and physical growth. The present study aimed to investigate differences in the metabolic substrates, lipids and proteins, between storage tissues from diploid and triploid female rainbow trout. Monthly, metabolic substrates were quantified in liver, muscle, and ovaries, which were collected during the first reproductive cycle. In general, it was possible to identify a seasonal and similar deposition of metabolites in different tissues of 2n and 3n females, mainly at early stages of gonadal maturation. However, from the stages 5-6, the ovaries showed great differences between ploidies, with higher concentration of lipids...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Metabolism; Reproduction; Triploidy; Somatic indexes; Oncorhynchus mykiss..
Ano: 2019 URL: http://periodicos.uem.br/ojs/index.php/ActaSciAnimSci/article/view/44580
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Dry and wet diets with and without phytase for growing and finishing pigs Animal Sciences
Oliveira, Luiz Alberto Garcia de; Universidade Federal de Goias; Nunes, Romão da Cunha; Universidade Federal de Goias; Rufino, Luciana Moura; Universidade Federal de Goias; Roner, Márcia Nunes Bandeira; Universidade Federal de Sergipe; Stringhini, José Henrique; Universidade Federal de Goias; Di Castro, Izabela Cruvinel; Universidade Federal de Goias.
The present study assessed the effect of adding water and phytase to middling diets on digestibility, metabolism, performance, carcass characteristics, and the bone mineralization of growing and finishing pigs. For the digestibility trial, 16 pigs were distributed in randomized blocks, placed in digestibility cages following a 2 x 2 factorial design (dry and wet diets, with and without phytase). For the performance trial, 48 piglets were distributed into a complete randomized design. During the growing period, wet diets presented higher values for digestibility and energy metabolism. In the finishing stage, the addition of water to the feed caused a greater weight gain and interfered with the carcass length. The balance of the mineral matter and the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 5.04.03.00-1 carcass length; Feed conversion; Digestibility; Metabolism.
Ano: 2014 URL: http://periodicos.uem.br/ojs/index.php/ActaSciAnimSci/article/view/22860
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Digestibility of the cottonseed meal with or without addition of protease and phytase enzymes in swine diet - doi: 10.4025/actascianimsci.v34i3.12360 Animal Sciences
Lorena-Rezende, Izaura Maria Barros de; Universidade Federal Rural de Pernambuco; Dutra Junior, Wilson Moreira; Universidade Federal Rural de Pernambuco; Rezende, Fabio Monteiro; Universidade Federal Rural de Pernambuco; Palhares, Liliane Olimpio; Universidade Federal Rural de Pernambuco; Ludke, Maria do Carmo Mouhaupt Marques; Universidade Federal Rural de Pernambuco; Rabello, Carlos Boa-Viagem; Universidade Federal Rural de Pernambuco.
This study evaluated the digestibility of cottonseed meal with or without addition of enzymes (phytase and protease) for growing pigs. It was used 18 barrows, housed in metabolism cages, distributed in a completely randomized design, standardizing body weight (bw) with average of 25.8 ± 3.6 kg, with three treatments and six repetitions. The treatments consisted of a reference diet based on corn and soybean meal, the second treatment with replacement of 30% of the reference diet by cottonseed meal without enzymes, and the third with 30% of the reference diet replaced by cottonseed meal with added enzymes. Was determined the digestible protein, digestible energy, digestibility of dry matter, energy and protein. It was also registered the balance of nitrogen...
Tipo: Pesquisa de campo Palavras-chave: Nutrição Animal alternative food; Exogenous enzymes; Metabolism; Non-ruminants.
Ano: 2012 URL: http://periodicos.uem.br/ojs/index.php/ActaSciAnimSci/article/view/12360
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Allosteric regulation of 6-phosphofructo-1-kinase activity of fat body and flight muscle from the bloodsucking bug Rhodnius prolixus Anais da ABC (AABC)
Alves,Gutemberg G.; Marinho-Carvalho,Monica M.; Atella,Georgia C.; Silva-Neto,Mario A.C.; Sola-Penna,Mauro.
6-phosphofructo-1-kinase (phosphofructokinase; PFK) activity from Rhodnius prolixus, a haematophagous insect which is usually a poor flyer, was measured and compared in two metabolically active tissues - flight muscle and fat body. The activity of this important regulatory glycolytic enzyme was much more pronounced in muscle (15.1 ± 1.4 U/mg) than in fat body extracts (3.6±0.4 U/mg), although the latter presented higher levels of enzyme per protein content, as measured by western-blotting. Muscle extracts are more responsible than fat body to ATP and fructose 6-phosphate, both substrates of PFK. Allosteric regulation exerted by different effectors such as ADP, AMP and fructose 2,6-phosphate presented a singular pattern for each tissue. Optimal pH (8.0-8.5)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phosphofructokinase; Metabolism; Insect.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000100008
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Oral insulin improves metabolic parameters in high fat diet fed rats Anais da ABC (AABC)
LIPINSKI,LEANDRO C.; KMETIUK,LOUISE B.; MATHIAS,PAULO C.F.; MALTA,ANANDA; FAVERO,GIOVANI M.; RIBEIRO,TATIANE A.; TOLEDO,ALCEU; NETTO,MARIO R. MONTEMOR; RODRIGUES,MARCOS R.S..
ABSTRACT Introduction/Aim: The gut has shown to have a pivotal role on the pathophysiology of metabolic disease. Food stimulation of distal intestinal segments promotes enterohormones secretion influencing insulin metabolism. In diabetic rats, oral insulin has potential to change intestinal epithelium behavior. This macromolecule promotes positive effects on laboratorial metabolic parameters and decreases diabetic intestinal hypertrophy. This study aims to test if oral insulin can influence metabolic parameters and intestinal weight in obese non-diabetic rats. Methods: Twelve weeks old Wistar rats were divided in 3 groups: control (CTRL) standard chow group; high fat diet low carbohydrates group (HFD) and HFD plus daily oral 20U insulin gavage (HFD+INS)....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Oral insulin; Intestine; Diabetes; Obesity; Metabolism; Pancreatic beta-cell.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401699
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Neutrotoxic effects of fructose administration in rat brain: implications for fructosemia Anais da ABC (AABC)
Macongonde,Ernesto A.; Costa,Naithan L.F.; Ferreira,Bruna K.; Biella,Mairis S.; Frederico,Marisa J.S.; Oliveira,Marcos R. de; Ávila Júnior,Silvio; Silva,Fátima R.M.B.; Ferreira,Gustavo C.; Streck,Emilio L.; Schuck,Patrícia F..
Fructose accumulates in tissue and body fluids of patients affected by hereditary fructose intolerance (HFI), a disorder caused by the deficiency of aldolase B. We investigated the effect of acute fructose administration on the biochemical profile and on the activities of the Krebs cycle enzymes in the cerebral cortex of young rats. Rats received a subcutaneous injection of NaCl (0.9 %; control group) or fructose solution (5 μmol/g; treated group). Twelve or 24 h after the administration, the animals were euthanized and the cerebral cortices were isolated. Peripheral blood (to obtain the serum) and cerebral spinal fluid (CSF) from the animals were also collected. It was observed that albumin levels were decreased and cholesterol levels were increased in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Brain damage; Fructose; Fructosemia; Hereditary fructose intolerance; Krebs cycle; Metabolism.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301451
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Metabolism and secretory function of white adipose tissue: effect of dietary fat Anais da ABC (AABC)
Nascimento,Cláudia M. Oller do; Ribeiro,Eliane B.; Oyama,Lila M..
Approximately 40% of the total energy consumed by western populations is represented by lipids, most of them being ingested as triacylglycerols and phospholipids. The focus of this review is to analyze the effect of the type of dietary fat on white adipose tissue metabolism and secretory function, particularly on haptoglobin, TNF-α, plasminogen activator inhibitor-1 and adiponectin secretion. Previous studies have demonstrated that the duration of the exposure to the high-fat feeding, amount of fatty acid present in the diet and the type of fatty acid may or may not have a significant effect on adipose tissue metabolism. However, the long-term or short-term high fat diets, especially rich in saturated fatty acids, probably by activation of toll-like...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adipokines; High fat diets; Metabolism; White adipose tissue.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300010
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Effects of insulin and actin on phosphofructokinase activity and cellular distribution in skeletal muscle Anais da ABC (AABC)
Silva,Ana Paula P.; Alves,Gutemberg G.; Araújo,Alexandre H.B.; Sola-Penna,Mauro.
In this work, we report evidences that the association of phosphofructokinase and F-actin can be affected by insulin stimulation in rabbit skeletal muscle homogenates and that this association can be a mechanism of phos-phofructokinase regulation. Through co-sedimentation techniques, we observed that on insulin-stimulated tissues, approximately 70% of phosphofructokinase activity is co-located in an actin-enriched fraction, against 28% in control. This phenomenon is accompanied by a 100% increase in specific phosphofructokinase activity in stimulated homogenates. Purified F-actin causes an increase of 230% in phosphofructokinase activity and alters its kinetic parameters. The presence of F-actin increases the affinity of phosphofructokinase for fructose...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phosphofructokinase; Hormone; Rabbit; Actin; Metabolism; Glycolysis.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000300008
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Phytogenic as feed additive for suckling dairy calves’ has a beneficial effect on animal health and performance Anais da ABC (AABC)
VOLPATO,ANDREIA; CRECENCIO,REGIANE B.; TOMASI,THAINÃ; GALLI,GABRIELA M.; GRISS,LUIZ GUSTAVO; SILVA,ANIÉLEN D. DA; SCHETINGER,MARIA ROSA C.; SCHOGOR,ANA LUIZA B.; BALDISSERA,MATHEUS D.; STEFANI,LENITA M.; SILVA,ALEKSANDRO S. DA.
Abstract: The aim of this study was to evaluate whether the use phytogenic as feed additive of Holstein calves could exert beneficial effects on animal health and performance. Thirty newborn calves were randomly divided into two groups (control and treated), and the treated consisted of 10 g of the phytogenic product diluted in milk once a day for 30 days. Blood and fecal samples were collected, and fecal score was performed daily in order to determine the occurrence of diarrhea. Treated calves showed higher hematocrit on days 45 and 60 of life. Serum levels of urea, total proteins, globulins and glucose were lower in the treated group on day 60 of life, while triglycerides were lower on days 15 and 60 of life. Serum glutathione S-transferase activity was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Feed; Metabolism; Calves; Oils; Nutrition; Animal health.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700804
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Metabolic dynamics of native lambs fed with Tifton 85 hay or Maniçoba hay associated with the spineless cactus Arq. Bras. Med. Vet. Zootec.
Soares,P.C.; Gouveia,L.N.F.; Silva,T.G.P.; O. Filho,E.F.; Carvalho,F.F.R.; Batista,Â.M.V.; Lima Júnior,D.M.; Cardoso,D.B..
ABSTRACT The objective of this study was to evaluate the metabolic response of native lambs fed Tifton 85 hay (Cynodon dactylon) or Maniçoba hay (Manihot pseudoglaziovii) associated with spineless cactus (Nopalea cochenillifera Salm Dyck). Sixteen Morada Nova lambs were used, with a mean initial weight of 19.36±1.48kg, distributed in a randomized block design, with two treatments and eight replications. Dry matter intake was higher for lambs fed Maniçoba hay compared to Tifton hay, while the body weight at slaughter was not influenced by diets. Regarding the blood metabolites, only the serum concentration of urea was influenced, with higher value observed in the lambs that fed the diet containing Tifton hay. When analyzing blood biomarkers, in the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Blood biomarkers; Clinical biochemistry; Metabolism; Native breeds; Nutrition; Small ruminants.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352020000100215
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Glycolysis and gluconeogenesis in the liver of catfish fed with different concentrations of proteins, lipids and carbohydrates Arq. Bras. Med. Vet. Zootec.
Melo,J.F.B.; Lundstedt,L. M; Inoue,L.A.K.; Metón,I.; Baanante,I.V.; Moraes,G..
ABSTRACT The activities of enzymes from a number of metabolic pathways have been used as a tool to evaluate the best use of nutrients on fish performance. In the present study the catfish Rhamdia quelen was fed with diets containing crude protein-lipid-carbohydrate (%) as follows: treatment (T) T1: 19-19-44; T2: 26-15-39; T3: 33-12-33; and T4: 40-10-24. The fish were held in tanks of re-circulated, filtered water with controlled temperature and aeration in 2000L experimental units. The feeding experiment lasted 30 days. The following enzymes of the carbohydrate metabolism were determined: Glucokinase (GK), Phosphofructokinase 1 (PFK-1), Pyruvate kinase (PK), Fructose-1,6-biphosphatase 1 (FBP-1). The activities of 6 phosphogluconate dehydrogenase (6PGDH)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Metabolism; Enzymes; Nutrition; Adaptation.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000501251
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Mastitis in the transition period: identification of potential blood markers Arq. Bras. Med. Vet. Zootec.
Santos,K.R.; Souza,F.N.; Blagitz,M.G.; Batista,C.F.; Bertagnon,H.G.; Gomes,R.C.; Molinari,P.C.C.; Diniz,S.A.; Silva,M.X.; Haddad,J.P.A.; Heinemann,M.B.; Libera,A.M.M.P.D..
ABSTRACT This study identified potential blood markers associated with mastitis in dairy cows under different dry therapies during the transition period, using a logistic regression model. Thirty-four Holstein dairy cows were divided into three groups: untreated controls (13 cows, 42 quarters); animals that received an antimicrobial at drying-off (10 cows, 40 quarters); and animals that were administered an internal teat sealant at drying-off (11 cow, 44 quarters). Blood and quarter milk samples were collected 60 days before the expected day of calving, on the day of calving, and three, seven, 15, 21, and 30 days after calving. Milk samples were submitted for bacteriological analysis and somatic cell count. Blood samples were collected for analyses of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Intramammary infection; Risk factor; Drying-off; Periparturient period; Metabolism.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000401120
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A model on biological flow of phosphorus in growing pigs Arq. Bras. Med. Vet. Zootec.
Lopes,J.B.; Moreira,J.A.; Kebreab,E.; Vitti,D.M.S.S.; Abdalla,A.L.; Crompton,L.A.; France,J..
Ten crossbred barrows weighting 20kg were allocated in five groups fed and on diets consisted of different total phosphorus (P) levels: 0.30%, 0.40%, 0.51%, 0.65%, and 0.73%. The animals were intravenously injected 7.4MBq of radioactive P (32P) and after seven days they were slaughtered for further analysis. The evaluated parameters were intake, excretion, specific activities, and flow of P in compartments (1-gut, 2-blood, 3-bone, and 4-soft tissue). Besides fecal losses, the kidneys played an import role in P regulation. The flows of P from tissue and gut to the blood were affected by P intake.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pig; Metabolism; Balance; True absorption; Radio-phosphorus; Kinetic.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352009000300024
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Symmorphosis in the proximal pathway for oxygen in the leaf-eared mouse Phyllotis darwini Biol. Res.
CANALS,MAURICIO; FIGUEROA,DANIELA; SABAT,PABLO.
In this report, we explore the matching of structures to functional needs by comparing previously reported data of maximal oxygen consumption and the development of the lung in the leaf-eared mouse Phyllotis darwini in warm and cold environments. We discuss whether the state of structural design is commensurate with functional needs from regulated morphogenesis as predicted by the hypothesis of symmorphosis. We found a close match between respiratory structures and functional needs during postnatal development, expressed as safety factors close to unity. However, in the adult stage the safety factors were greater than two, which suggests that adult animals acquired a structure greater than that required considering their maximum capacities. A high safety...
Tipo: Journal article Palavras-chave: Metabolism; Ontogeny; Phyllotis darwini; Symmorphosis.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000100009
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Increasing the rate of drying reduces metabolic imbalance, lipid peroxidation and critical water content in radicles of garden pea (Pisum sativum L.) Biol. Res.
Ntuli,Tobias M; Pammenter,Norman W; Berjak,Patricia.
Orthodox seeds become desiccation-sensitive as they undergo germination. As a result, germinating seeds serve as a model to study desiccation sensitivity in plant tissues. The effects of the rate of drying on the viability, respiratory metabolism and free radical processes were thus studied during dehydration and wet storage of radicles of Pisum sativum. For both drying regimes desiccation could be described by exponential and inverse modified functions. Viability, as assessed by germination capacity and tetrazolium staining, remained at 100% during rapid (< 24 h) desiccation. However, it declined sharply at c. 0.26 g g¹ dm following slow (c. 5 days) drying. Increasing the rate of dehydration thus lowered the critical water content for survival. Rapid...
Tipo: Journal article Palavras-chave: Antioxidant; Desiccation; Drying rate; Free radical processes; Lipid peroxidation; Metabolism; Respiration; Pisum sativum; Seed storage.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000200002
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Metabolic and behavioral effects of ractopamine at continuous low levels in rats under stress BABT
Lopes,Edna; Sousa,Raimundo Vicente de; Zangeronimo,Márcio Gilberto; Pereira,Andressa Naira de Jesus; Coelho,Mariana de Resende; Ferreira,Matheus Soares da Silva; Lima,Renato Ribeiro; Marcondes,Fernanda Klein; Napimoga,Marcelo Henrique; Pereira,Luciano José.
This study aimed at evaluating the effect of ractopamine (RAC) on metabolism, zootechnical performance, body composition, and behavior in Wistar rats submitted to acute and chronic restrain stress. The oral dose of 5 mg/kg of RAC was administered in periods of 0, 7, 14, 21, and 28 days. The elevated plus-maze test (EPMT) was used for behavioral assessment. Blood, carcass and viscera characteristics were evaluated. Insulin-dependent glucose transporters (GLUT-4) were semi-quantified by Western Blot in epididymal adipocytes. RAC periods associated with chronic stress increased the GLUT-4 protein expression in adipose tissue in a time-dependent manner (P=0.01), i.e., the longer the RAC addition period, the higher the GLUT-4 concentration in chronically...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Β-adrenergic agonist; Ractopamine; Zootechnical performance; Metabolism; Elevated Plus-Maze Tests.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000300406
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Use of metabolism and swimming activity to evaluate the sublethal toxicity of surfactant (LAS-C12) on Mugil platanus BABT
Barbieri,Edison.
This study aimed to investigate the toxicological effects of the LAS-C12 on Mugil platanus (mullet). Fishes exposed to 1.0 mg.L-1 for 24, 48, 72, 96 and 120 hours presented significant increase in specific routine metabolism. At the concentration of 0.5 mgL-1, the active metabolism presented a decreasing trend from 48 h of exposure on. However, only the consumption averages for 72 h were statistically different from the ones obtained for other periods of exposure. The lowest oxygen consumption in this concentration was observed for 24, 48 and 72 hours of exposure. Significant differences between the control and the concentration of 2.5 mgL-1 were observed for the different periods of exposure. It was not possible to measure the consumption of oxygen for 96...
Tipo: Info:eu-repo/semantics/article Palavras-chave: LAS; Swimming performance; Oxygen consumption; Metabolism; Detergents.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000100012
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Diets Rich in Polyunsaturated Fatty Acids With Different Omega-6/Omega-3 Ratio Decrease Liver Content of Saturated Fatty Acids Across Generations of Wistar Rats BABT
Halfen,Simone; Jacometo,Carolina Bespalhok; Mattei,Patrícia; Fenstenseifer,Samanta Regine; Pfeifer,Luiz Francisco Machado; Pino,Francisco Augusto Burkert Del; Santos,Marco Aurélio Ziemann; Pereira,Cláudio Martin Pereira de; Schmitt,Eduardo; Corrêa,Marcio Nunes.
Our study evaluated how the consumption of diets with low (LOW group - 0.4/1) or high (CON group - 13.6/1) omega-6/omega-3 ratio across generations (F1 and F2) can modulate liver fatty acid (FA) profile and blood biomarkers. Liver content of α-linolenic acid was higher in animals always fed with LOW diet than animals that changed from CON to LOW diet, which by your time was higher than animals always fed with CON diet. Liver saturated FA concentration decreased in both groups from F1 to F2. In conclusion, both diets were efficient in decreasing the saturated FA liver content across generations, the LOW ratio diet was more effective in reducing blood triglycerides and non-esterified fatty acids, and there was a multigenerational effect of the LOW ratio...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Alpha-linolenic acid; Essential fatty acid; Lipid; Metabolism; Nutrition; Rats.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100503
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Bone mineral density and vitamin D concentration: the challenges in taking care of children and adolescents infected with HIV BJID
Carmo,Fabiana Bononi; Terreri,Maria Teresa; Succi,Regina Célia de Menezes; Beltrão,Suenia Vasconcelos; Gouvea,Aida de Fátima Tomé Barbosa; Paulino,Erica Regina Cruz; Machado,Daisy Maria.
ABSTRACT Background: The increase in life expectancy for patients living with human immunodeficiency virus (HIV) infection has resulted in health complications related to a chronic disease. Objectives: To evaluate the prevalence of bone mineral density (BMD) alterations and vitamin D concentrations in HIV-infected children and adolescents and to verify the variations in those parameters during a 12-month interval. Methods: A prospective cohort study with a dual period of evaluation was conducted in 57 patients perinatally HIV-infected and one patient with sexual abuse in early infancy. Demographic, anthropometric, pubertal stage, viral load, T CD4+ cell count and antiretroviral therapy were evaluated. Biochemical tests and total body (TB) and lumbar...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Antiretroviral; Infant; Diagnosis; Metabolism; Bone.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300270
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Chlorophyll treatment combined with photostimulation increases glycolysis and decreases oxidative stress in the liver of type 1 diabetic rats BJMBR
Wunderlich,A.L.M.; Azevedo,S.C.S.F.; Yamada,L.A.; Bataglini,C.; Previate,C.; Campanholi,K.S.S.; Pereira,P.C.S.; Caetano,W.; Kaplum,V.; Nakamura,C.V.; Nakanishi,A.B.S.; Comar,J.F.; Pedrosa,M.M.D.; Godoi,V.A.F..
Photodynamic therapy (PDT) promotes cell death, and it has been successfully employed as a treatment resource for neuropathic complications of diabetes mellitus (T1DM) and hepatocellular carcinoma. The liver is the major organ involved in the regulation of energy homeostasis, and in pathological conditions such as T1DM, changes in liver metabolic pathways result in hyperglycemia, which is associated with multiple organic dysfunctions. In this context, it has been suggested that chlorophyll-a and its derivatives have anti-diabetic actions, such as reducing hyperglycemia, hyperinsulinemia, and hypertriglyceridemia, but these effects have not yet been proven. Thus, the biological action of PDT with chlorophyll-a on hepatic parameters related to energy...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Photopigment; Diabetes; Metabolism; Free Radicals; Phototherapy.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000100601
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