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| Registros recuperados: 273 | |
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| Kunwar Awaneesh Singh; Chandan Singh; G.R.K. Rao; M.V. Jagannatham. |
| Crinumin, a glycosylated serine protease with chymotrypsin like catalytic specificity was purified from a medicinally important plant _Crinum asiaticum_ of family _Amaryllidaceae_. Ethno-botanical information and Pharmacological studies confirming about the presence of active bio- molecules in the _Crinum_ played crucial role in injury, inflamed joint, local pain and arthritis. Biomedical research suggests chymotrypsin was not only used as digestive aid but also helpful in the above disease. These findings support towards the crinumin may be the active bio-molecule. Crinumin shows activity over a wide range of pH (4.5-11.5 and optimum at 8.5), temperature (75 °C and optimum at 70 °C) and is also functional against chaotrophs, organic... |
| Tipo: Poster |
Palavras-chave: Pharmacology; Plant Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4339/version/1 |
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| Danish Ahmed; Sweta Kumari; Shruti Mishra; Shivangi Jaiswal. |
| Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored. These included oral, rectal, sublingual, buccal, transdermal, vaginal, intramuscular, intrapulmonary, and intranasal delivery systems. The purpose of these latter studies was to determine a noninjectable method to deliver insulin to patients with type 1 and 2 diabetes that would effectively lower blood sugar, control hemoglobin A1c (in much later studies), and allow patients a simpler, less invasive, and more direct control oftheir underlying disease process.  In January 2006 the United States Food and Drug Administration approved Exubera (Pfizer Pharmaceuticals, New York, NY) as... |
| Tipo: Poster |
Palavras-chave: Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/7115/version/1 |
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| Rahul Verma; Amit Misra. |
| In spite of extensive research in tuberculosis (TB), it is still one of the major infectious diseases and cause of high mortality worldwide. To enhance efficacy with lower dosing, newer drug delivery systems has been developed which provide targeted drug delivery and controlled release at the primary site of infection, i.e., the lung macrophage. Our lab has previously reported poly(D, L-lactic acid) (PLA) microparticles containing rifabutin (RFB) and isoniazid (INH) for pulmonary delivery and explored various facets of treatment with microparticle DPI. We have utilized this dry powder aerosol drug delivery system to deposit drugs directly at the site of infection in lungs and have been investigating such DPI as a novel approach to increase therapeutic... |
| Tipo: Poster |
Palavras-chave: Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/7061/version/1 |
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| Galila Agam; Miriam Eisenstein; Itshak Levi; Yael Askira; Orna Almog; Chaim Gilon; Amnon Hoffman; Yftah Talgan; Joseph Fanous. |
| Among numerous reported biochemical effects the lithium-inhibitable enzyme inositol-monophosphatase (IMPase) remains a viable target for lithium's therapeutic mechanism of action. Calbindin-D28k (calbindin) interacts with IMPase enhancing its activity. In the present study in silico modeling of IMPase-calbindin binding using the program MolFit indicated that the 55-66 amino acid segment of IMPase anchors calbindin via Lys59 and Lys61 with a glutamate in between (Lys-Glu-Lys motif). The model further suggested that the Lys-Glu-Lys motif interacts with residues Asp24 and Asp26 of calbindin. Indeed, we found that differently from wildtype calbindin, IMPase was not activated by mutated calbindin in which Asp24 and Asp26 were replaced by alanine.... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience; Pharmacology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6323/version/1 |
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| Awadh Bihari Yadav; Amit Misra. |
| We compared the effects of microparticles (MP) containig anti-tubercular drugs and those of the drugs themselves on the host macrophage (MΦ) response to infection with Mycobacterium tuberculosis H37Ra (Mtb). 
Mice infected intravenously with M. tb. were either administered rifampicin and isoniazid by oral gavage or through inhalation of biodegradable MP containing the two anti-tubercular drugs. Bronchoalveolar lavage (BAL) was perfomed to recover lung MΦ, which were cultured and the supernatant analysed for TNFα by ELISA. The murine MΦ cell line J774 or the human monocyte line THP-1 differentiated with phorbol myristate were infected in vitro and treated with MP or soluble drugs. The kinetics of... |
| Tipo: Poster |
Palavras-chave: Immunology; Pharmacology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1190/version/1 |
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| Bernd Kastenholz; Basil Horst; Jürgen Horst. |
| Commercially available medicinal plant extracts such as Ginkgo biloba leaf extract show no consistent pattern of clinical benefit for people with dementia or cognitive impairment, and have been suggested to be toxic to cells at higher doses. However, medicinal plants may contain other more efficient bioactive molecules apart from the well-known flavonoids and terpenoids. Therapeutic recombinant proteins, plant-made copper chaperone for superoxide dismutase (CCS) derived from Ginkgo biloba leaves, may establish and maintain physiologic Cu levels through restoration and modulation of biometal metabolism in organ systems of younger Alzheimer patients (> 50 years). Medications developed from plant-made copper chaperone proteins may delay progression... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience; Pharmacology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5907/version/7 |
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| Geeta Negi; Ashutosh Kumar; Shyam S. Sharma. |
| Oxidative stress and inflammation are two well-recognized events occurring in normal cells during cancer chemotherapy. Several antioxidant and anti-inflammatory agents have therefore been tried as rational and effective strategies for chemoprotection. Elaborate studies on antioxidants and anti-inflammatory agents in various experimental models of cancer revealed that these agents act by modulating the expression and/or activity of the transcription factors nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB). Nrf2 is considered the main sentinel of antioxidant defense as it induces many antioxidant and phase 2 enzymes in response to stressful conditions. Likewise, NF-κB is considered as a denominator of... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Pharmacology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6581/version/1 |
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| Ting-Chao Chou. |
| The unified theory of dose and effect, as indicated by the median-effect equation for single and multiple entities and for the first and higher order kinetic/dynamic, has been established by T.C. Chou and it is based on the physical/chemical principle of the mass-action law (_J. Theor. Biol._ 59: 253-276, 1976; _Pharmacological Rev._ 58: 621-681, 2006). Rearrangements of the median-effect equation lead to Michaelis-Menten, Hill, Scatchard, and Henderson-Hasselbalch equations. The “median” serves as the “universal reference point” and the “common link” for the relationship of all entities at all dynamic orders, and is also the “harmonic mean” of kinetic dissociation... |
| Tipo: Presentation |
Palavras-chave: Biotechnology; Pharmacology; Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2064/version/1 |
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| Madike Ezeibe; George Anosa; Okechi Okorie; Nnenna Elendu-Eleke; Obianuju Okoroafor; Augustine Ngene; Ogechukwu Chikelu. |
| Solutions of different concentrations, of Ampicillin trihydrate (AT) and of a formulation of AT in Aluminium Magnesium Silicate (AMS), were used for sensitivity test on Salmonella gallinarum cultures. Also, S. gallinarum-infected chicks were treated with; 10 mg / Kg (AT), 10 mg / Kg (AT in AMS), 7.5 mg / Kg ( AT), 7.5 mg /Kg (AT in AMS). Mean inhibition area, 28.39 mm produced by AT did not vary significantly (P ) from 26.36 mm produced by AT in AMS. However, 17.5 105 Salmonella gallinarum culture forming units per ml of bile of the untreated chicks and 3.4 105 (80.58 % reduction), 2.5 105 (85.7 % reduction) , 5.4 105 (69.2 % reduction ) and 0.38 105 (97.8 % reduction ) of the respective treated groups, showed AMS significantly (P 0.01) improved AT`s... |
| Tipo: Manuscript |
Palavras-chave: Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6814/version/1 |
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| Vijaya Dubey; Nusrat Masood; Suaib Luqman; Arvind S. Negi. |
| Cancer, one of the leading causes of death worldwide, is an abnormal cell proliferation that fails to respond to the normal signals. In an effort to eradicate the growing menace of cancer, a clear understanding of fundamental biology and molecular mechanism of carcinogenesis is essential for targeted therapies. Among the devised strategies in use for cancer treatment, the one that is of immense interest is the development of plant based novel anticancer agents. Due to their tremendous availability, biological activity and efficacy, the phytochemicals deemed a gibbous future in chemoprevention. In the present study, several phenolics based structurally related compounds of steroidal and non-steroidal skeleton were synthesized and tested for their... |
| Tipo: Poster |
Palavras-chave: Cancer; Chemistry; Pharmacology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6644/version/1 |
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| I. C. Baianu. |
| An overview of translational, human oncogenomics, transcriptomics and cancer interactomic networks is presented together with basic concepts and potential, new applications to Oncology and Integrative Cancer Biology. Novel translational oncogenomics research is rapidly expanding through the application of advanced technology, research findings and computational tools/models to both pharmaceutical and clinical problems. A self-contained presentation is adopted that covers both fundamental concepts and the most recent biomedical, as well as clinical, applications. Sample analyses in recent clinical studies have shown that gene expression data can be employed to distinguish between tumor types as well as to predict outcomes. Potentially important applications... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Chemistry; Developmental Biology; Genetics & Genomics; Immunology; Molecular Cell Biology; Pharmacology; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6190/version/2 |
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| Danish Ahmed; Manju Sharma; Vikas Kumar; Pankaj S Yadav. |
| Contemporary therapies to rationalize the hyperglycaemia in type 2 diabetes mellitus (T2DM) generally involve insulin-dependent mechanisms and lose their effectiveness as pancreatic b-cell function decreases to a greater extent. The kidney emerges out as a novel and potential target to trim down the T2DM. The filtered glucose is reabsorbed principally through the sodium glucose co-transporter-2 (SGLT2), a low affinity transport system, which is present at the luminal surface cells that cover the first segment of proximal tubules. Competitive inhibition of SGLT2 therefore represents an innovative therapeutic strategy for the treatment of hyperglycaemia and/or obesity in patients with type 1 or type 2 diabetes by enhancing glucose and energy loss through the... |
| Tipo: Manuscript |
Palavras-chave: Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/7057/version/1 |
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| C. S. Lin; Jhen Ru Shih; C. H. Hsu; Z.H. Wen; Chiranjib Chakraborty. |
| Expression of the target gene is important for gene therapy. Presently, localized transgenesis is used for gene therapy which can be achieved by a target gene expression. Here, we have reported the plasmid mediated gene therapy to zebrafish model. For this purpose, we have chosen green fluorescent protein (GFP) as a target gene because the expression can be detected easily. GFP was inserted in a plasmid vector, pQE30 to develop the vector pQE30GFP. The plasmid pQE30GFP was constructed form plasmid, pQE30 and pEGFPC2. pQE30GFP injected directly in one group of fish into the muscle where luciferase expression was noted. In another group, after injection electroporation was performed where we have also noted luciferase expression; but, electroporation cause... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Genetics & Genomics; Pharmacology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2718/version/1 |
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| Aijaz A. Rashid; Perminder P. Sing. |
| Critical concentration gradient model is helpful in understanding the mechanism of Z-ring formation. The distribution of positive and negative regulators of Z-ring formation in cell is not random but well programmed. The positive and negative regulators in cell lead to a critical concentration gradient from mid cell to the poles. The critical concentration of FtsZ required for Z-ring assembly at the centre of cell is less than that at the poles. So FtsZ starts polymerizing at cell centre and afterwards by cooperative association of more and more monomers leads to the Z-ring formation. Simultaneously during Z-ring formation the recruitment of other accessory proteins takes place, leading to the formation of a stable divisome complex. |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Microbiology; Pharmacology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4659/version/1 |
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| Davor Juretic; Nada Ilic; Damir Vukicevic; Nikolinka Antcheva; Alessandro Tossi. |
| New antibiotics against multidrug-resistant bacteria are urgently needed, but rapid acquisition of resistance limits their usefulness. Endogenous antimicrobial peptides (AMPs) with moderate selectivity, but multimodal mechanism of action, have remained effective against bacteria for millions of years. Their therapeutic application, however, requires optimizing the balance between antibacterial activity and selectivity, so that rational design methods for increasing selectivity are highly desirable. We have created training (n=36) and testing (n=37) sets from frog-derived AMPs with determined therapeutic index (TI). The 'sequence moments' concept then enabled us to find a one-parameter linear model resulting in a good correlation between... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Pharmacology; Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3068/version/1 |
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| Hidechika Okada; Noriko Okada; Masaki Imai; Alan Okada; Fumiko Ono. |
| Antibodies to C5a have proven to be effective in treating experimental septic primate models. A 17 amino acid peptide (ASGAPAPGPAGPLRPMF) named PepA binds to C5a and prevents complement-mediated lethal shock in rats. AcPepA harboring an acetyl group at the N-terminal alanine showed increased inhibitory activity against C5a. Cynomolgus monkeys destined to expire from a lethal dose of bacterial endotoxin (4mg/kg) were rescued by intravenous administration of AcPepA. AcPepA could have interfered with the ability of C5a to stimulate C5L2 which is responsible for HMGB1 release and stimulation of TLR4 as an endogeneous ligand with LPS behavior. The suppression of HMGB1 release by AcPepA administration to LPS-shock monkeys is likely responsible for rescuing the... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Immunology; Pharmacology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5727/version/1 |
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| Kushal Sarda; Vijaya Pandit; Jayshree Dawane; Gourav Deshmane. |
| Objective: To evaluate the mechanism of action of Krishnavajrabhraka Bhasma(KVB) in chronic asthma.
Methodology: 30 animals divided into 5 groups: 1)vehicle(water) 2)vehicle(honey) 3)Low dose KVB 4)High dose KVB 5)Standard drug.
Expt I:- Mast cell stabilization-
On day 1, animals were sensitized with egg albumin. Treatment started from day 22 in two ways: a)Single dose b)14days. Egg albumin challenge was given at the end of the treatment. Rats were sacrificed, mesentery collected & observed for mast cell degranulation. 
Expt II:- Anti-inflammatory action-
Croton oil was injected in the back in all rats to make a pouch. After 7 days of drug treatment, animals... |
| Tipo: Presentation |
Palavras-chave: Pharmacology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5422/version/1 |
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| Registros recuperados: 273 | |
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