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| Registros recuperados: 45 | |
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| Johann,Susana; Smânia-Jr,Artur; Pizzolatti,Moacir G.; Schripsema,Jan; Braz-Filho,Raimundo; Branco,Alexsandro. |
| A mixture of the two new flavonols 8-hydroxy-3, 4', 5, 6, 7-pentamethoxyflavone (1) and 8-hydroxy-3, 3', 4', 5, 6, 7-hexamethoxyflavone (2) was isolated from a commercial sample of Citrus aurantifolia. An array of one- (¹HNMR, {¹H}-13C NMR, and APT-13C NMR) and two-dimensional NMR techniques (COSY, NOESY, HMQC and HMBC) was used to achieve the structural elucidation and the complete ¹H and 13C chemical shift assignments of these natural compounds. In addition, the antifungal activity of these compounds against phytopathogenic and human pathogenic fungi was investigated. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Polymethoxyflavones; Antifungal activity; Citrus aurantifolia. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000200004 |
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| Tsuzuki,Joyce K.; Svidzinski,Terezinha I.E.; Shinobu,Cristiane S.; Silva,Luiz F.A.; Rodrigues-Filho,Edson; Cortez,Diógenes A.G.; Ferreira,Izabel C.P.. |
| Extracts from the dried pericarp of Sapindus saponaria L. (Sapindaceae) fruits were investigated for their antifungal activity against clinical isolates of yeasts Candida albicans and C. non-albicans from vaginal secretions of women with Vulvovaginal Candidiasis. Four clinical isolates of C. albicans, a single clinical isolated of each of the species C. parapsilosis, C. glabrata, C. tropicalis, and the strain of C. albicans ATCC 90028 were used. The hydroalcoholic extract was bioactivity-directed against a clinical isolate of C. parapsilosis, and showed strong activity. The n-BuOH extract and one fraction showed strong activity against all isolates tested. Further column-chromatography on silica gel separation of this fraction afforded two pure triterpene... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sapindaceae; Sapindus saponaria; Saponins; Antifungal activity; Candida. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000400002 |
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| VALADARES,ANNA CAROLINA F.; ALVES,CASSIA CRISTINA F.; ALVES,JOSÉ MILTON; DE DEUS,ISABELLA P.B.; DE OLIVEIRA FILHO,JOSEMAR G.; DOS SANTOS,TAINÁ CAROLINE L.; DIAS,HERBERT JÚNIOR; CROTTI,ANTÔNIO EDUARDO M.; MIRANDA,MAYKER L.D.. |
| Abstract Even though essential oils from Piper aduncum (Piperaceae) have different biological activities, little is known about their application to agricultural areas. White mold is a plant disease caused by the phytopathogen Sclerotinia sclerotiorum, which needs to be controlled by alternative measures. This study aimed at evaluating the effect of essential oils from P. aduncum leaves (PL-EO) and inflorescences (PI-EO) on the mycelial growth of S. sclerotiorum. Essential oils from P. aduncum were obtained by hydrodistillation by a Clevenger-type apparatus while their chemical composition was analyzed by GC-MS and GC-FID. Piperitone (23.4 %), myristicin (12.4 %), terpinen-4-ol (12.3 %), β-caryophyllene (7.2 %), α-humulene (6.9 %), germacrene-D (6.9 %) and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Piper aduncum; Essential oils; Piperitone; Antifungal activity; Sclerotinia sclerotiorum. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000602691 |
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| Agripino,Débora Gomes; Lima,Marcos Enoque Leite; Silva,Marcelo Rogério da; Meda,Cristiane Infante; Bolzani,Vanderlan da Silva; Cordeiro,Inês; Young,Maria Claudia Marx; Moreno,Paulo Roberto H.. |
| I. Atlantic Rain Forest . Ecological Station Juréia-Itatins) Crude extracts from 88 plant species occurring in São Paulo State (Brazil), collected in an Atlantic Forest region, have been screened for antimicrobial and DNA-damaging activities. Of the 114 extracts assayed for antibacterial activity, only the extracts from leaves and stems of Aspidosperma ramiflorum (Apocynaceae) showed a slight activity against Escherichia coli. In the antifungal assay with Candida albicans, no active extract was observed, while in the bioautography assay with Cladosporium sphaerospermum and C. cladosporioides 12% were active. However, only the extract of Psychotria mapoureoides (Rubiaceae) stems showed a strong inhibition of both fungi. The DNA-damaging assay with mutant... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Atlantic Rain forest; Antibacterial activity; Antifungal activity; Antitumoral activity; Plants screening. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032004000200009 |
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| Gerige,Saptha Jyothi; Gerige,Mahesh Kumar Yadav; Rao,Muralidhara; Ramanjaneyulu,. |
| The present study dealt with the hydro distillation of Nigella sativa seeds and GC-MS analysis. The total composition of the oil was 86.7%. The seed volatile oil was tested against 19 microbes (Gram positive, Gram negative and fungi), which showed that Gram negative bacteria Haemophilus influenza, Klebsiella pnemoniae, and Proteus vulgaris were highly sensitive against the antimicrobial agent, whereas the fungi such as Trichoderma vibriae,. Pencillium rubrum; and Dermatophyte: Trichophyton mentagrophytes; had no response at the 20µl concentration. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nigella sativa; Volatile oil; Antimicrobial activity; Antifungal activity. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000500016 |
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| Faria,Terezinha de Jesus; Ferreira,Rafael Sottero; Yassumoto,Lidiane; Souza,José Roberto Pinto de; Ishikawa,Noemia Kazue; Barbosa,Aneli de Melo. |
| An investigation of antifungal activity of the essential oil obtained by steam-distillation (1.1% w/w) of the aerial parts of Ocimum gratissimum and of an ethanolic extract from the steam-distillation residue was carried out using the agar diffusion method. The results revealed that the essential oil inhibited the growth of all fungi tested, including the phytopathogens, Botryosphaeria rhodina, Rhizoctonia sp. and two strains of Alternaria sp., while the extract from the residue was inactive. The essential oil was subjected to TLC bioautography used to detect fungitoxic constituents. The compound that showed antifungal activity was isolated and identified as eugenol. GC/MS analysis showed that eugenol was the main constituent of the essential oil studied.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ocimum gratissimum; Antifungal activity; Eugenol; Phytopathogenic fungi. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000700002 |
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| Fagundes,Miriã Cristina Pereira; Oliveira,Adelson Francisco de; Carvalho,Vicente Luiz de; Ramos,José Darlan; Santos,Verônica Andrade dos; Rufini,José Carlos Moraes. |
| ABSTRACT The aim of this study was to evaluate the antifungal action of ethanolic extracts of avocado seeds, by conducting two experiments in the laboratory of plant pathology of EPAMIG SUL/Lavras, MG, Brazil, in a completely randomized design with three replicates. The first consisted of the following treatments ('Breda' 3%, 'Breda' 2%, 'Margarida' 3%, 'Margarida' 2%, Control, and Ethanol) testing its inhibitory effect on two fungal species (Colletotrichum gloeosporioides and Monilinia fructicola) and the second consisted of different concentrations of extracts (0%, 0.25%, 0.50%, 0.75%, 1.0%, 1.5%, and 2.0%) on the fungus F fructicola. The evaluations were performed at three times (7, 14, and 21 days of incubation) by measurements of the mycelial diameter... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antifungal activity; Colletotrichum gloeosporioides; Monilinia fructicola; Postharvest. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100204 |
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| Oliveira Junior,Enio Nazaré de; Melo,Itamar Soares de; Franco,Telma Teixeira. |
| In this work, changes in the hyphal morphology due to chitosan treatment in some fungal species were studied. Scanning electron microscope (SEM) observations revealed that chitosans with molar fraction of acetyl groups (F A 0.16 and 0.18) and degree of polymerization (DP 1,089 and 1,242) had a direct effect on the morphology of the chitosan-treated fungi, reflecting its potential for causing a delay in the growth of Alternaria alternata (500 µg × mL-1), Botrytis cinerea (1,000 µg × mL-1), Penicillium expansum (1,000 µg × mL-1) and Rhizopus stolonifer (500 µg × mL-1). Mycelial aggregation and structural changes such as excessive branching, swelling of the cell wall and hyphae size reduction were observed in the micrographs. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chitosan; Alternative control of fungi; Antifungal activity; Plant pathogenic fungi; Fungal morphology. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000500001 |
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| Silva,Cristiane de Bona da; Guterres,Sílvia S.; Weisheimer,Vanessa; Schapoval,Elfrides E.S.. |
| Superficial mycoses of the skin are among the most common dermatological infections, and causative organisms include dermatophytic, yeasts, and non-dermatophytic filamentous fungi. The treatment is limited, for many reasons, and new drugs are necessary. Numerous essential oils have been tested for both in vitro and in vivo antifungal activity and some pose much potential as antifungal agents. By using disk diffusion assay, we evaluated the antifungal activity of lemongrass oil and citral against yeasts of Candida species (Candida albicans, C. glabrata, C. krusei, C. parapsilosis and C. tropicalis). This study showed that lemongrass oil and citral have a potent in vitro activity against Candida spp. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lemongrass oil; Citral; Antifungal activity; Candida spp. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100014 |
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| Brilhante,Raimunda Sâmia Nogueira; Caetano,Erica Pacheco; Oliveira,Jonathas Sales de; Castelo-Branco,Débora de Souza Collares Maia; Souza,Elizabeth Ribeiro Yokobatake; Alencar,Lucas Pereira de; Cordeiro,Rossana de Aguiar; Bandeira,Tereza de Jesus Pinheiro Gomes; Sidrim,José Júlio Costa; Rocha,Marcos Fábio Gadelha. |
| ABSTRACTThe antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested againstCandida spp. and Cryptococcus spp. Then, in a second approach, considering that the best results were obtained for simvastatin, this drug was evaluated in combination with antifungal drugs against planktonic growth and tested against biofilms ofCandida spp. and Cryptococcus spp. Drug susceptibility testing was performed using the microdilution broth method, as described by the Clinical and Laboratory Standards Institute. The interaction between simvastatin and antifungals against planktonic cells was analyzed by calculating the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Candida; Cryptococcus; Simvastatin; Antifungal activity; Biofilm. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500459 |
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| Chami,N.; Chami,F.; Bennis,S.; Trouillas,J.; Remmal,A.. |
| Carvacrol and eugenol, the main (phenolic) components of essential oils of some aromatic plants, were evaluated for their therapeutic efficacy in the treatment of experimental oral candidiasis induced by Candida albicans in immunosuppressed rats. This anticandidal activity was analyzed by microbiological and histopathological techniques, and it was compared with that of nystatin, which was used as a positive control. Microbiologically, carvacrol and eugenol significantly (p<0.05) reduced the number of colony forming units (CFU) sampled from the oral cavity of rats treated for eight consecutive days, compared to untreated control rats. Treatment with nystatin gave similar results. Histologically, the untreated control animals showed numerous hyphae on... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Carvacrol; Eugenol; Experimental oral candidiasis; Antifungal activity; Essential oils. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300005 |
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| Santos,Maximillan Leite; Magalhães,Chaiana Froés; Rosa,Marcelo Barcellos da; Santos,Daniel de Assis; Brasileiro,Beatriz Gonçalves; Carvalho,Leandro Machado de; Silva,Marcelo Barreto da; Zani,Carlos Leomar; Siqueira,Ezequias Pessoa de; Peres,Rodrigo Loreto; Andrade,Anderson Assunção. |
| The effects of different solvents and extraction techniques upon the phytochemical profile and anti-Trichophyton activity of extracts from Piper aduncum leaves were evaluated. Extract done by maceration method with ethanol has higher content of sesquiterpenes and antifungal activity. This extract may be useful as an alternative treatment for dermatophytosis. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antifungal activity; Piper aduncum L.; Dermatophytes; Trichophyton; Extraction techniques. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000400035 |
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| Pan,Feng; Liu,Zheng-Qiong; Chen,Que; Xu,Ying-Wen; Hou,Kai; Wu,Wei. |
| Abstract The aim of this paper is to identify and investigate an endophytic fungus (strain 28) that was isolated from Houttuynia cordata Thunb, a famous and widely-used Traditional Chinese Medicine. Based on morphological methods and a phylogenetic analysis of ITS sequences, this strain was identified as Chaetomium globosum. An antifungal activity bioassay demonstrated that the crude ethyl acetate (EtOAc) extracts of strain 28 had a wide antifungal spectrum and strong antimicrobial activity, particularly against Exserohilum turcicum (Pass.) Leonard et Suggs, Botrytis cinerea persoon and Botrytis cinerea Pers. ex Fr. Furthermore, the fermentation conditions, extraction method and the heat stability of antifungal substances from strain 28 were also studied.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Endophytic fungi; Houttuynia cordata Thunb.; Chaetomium globosum; Antifungal activity; Process parameter. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000200480 |
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| Shentu,Xuping; Zhan,Xiaohuan; Ma,Zheng; Yu,Xiaoping; Zhang,Chuanxi. |
| The endophytic fungus strain 0248, isolated from garlic, was identified as Trichoderma brevicompactum based on morphological characteristics and the nucleotide sequences of ITS1-5.8SITS2 and tef1. The bioactive compound T2 was isolated from the culture extracts of this fungus by bioactivity-guided fractionation and identified as 4β-acetoxy-12,13-epoxy-Δ9-trichothecene (trichodermin) by spectral analysis and mass spectrometry. Trichodermin has a marked inhibitory activity on Rhizoctonia solani, with an EC50 of 0.25 µgmL-1. Strong inhibition by trichodermin was also found for Botrytis cinerea, with an EC50 of 2.02 µgmL-1. However, a relatively poor inhibitory effect was observed for trichodermin against Colletotrichum lindemuthianum (EC50 = 25.60 µgmL-1).... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Trichoderma brevicompactum; Garlic; Endophytic fungus; Trichodermin; Antifungal activity. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000100036 |
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| Guerra,Felipe Q.S.; Araújo,Rodrigo S.A.; Sousa,Janiere P.; Silva,Viviane A.; Pereira,Fillipe O.; Mendonça-Junior,Francisco J.B.; Barbosa-Filho,José M.; Pereira,Julio Abrantes; Lima,Edeltrudes O.. |
| Abstract Fungal infections have become a concern for health professionals, and the emergence of resistant strains has been reported for all known classes of antifungal drugs. Among the fungi causing disease, we highlight those that belong to the genus Aspergillus. For these reasons, the search for new antifungals is important. This study examines the effects of a coumarin derivative, 4-acetatecoumarin (Cou-UMB16) both alone and together with antifungal drugs, and its mode of action against Aspergillus spp. Cou-UMB16 was tested to evaluate its effects on mycelia growth, and germination of Aspergillus spp. fungal conidia. We investigated its possible action on cell walls, on the cell membrane, and also the capacity of this coumarin derivative to enhance the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Coumarin; Antifungal activity; A. flavus; A. fumigatus; Mode of action. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200407 |
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| Caneschi,César Augusto; Almeida,Angelina Maria de; Martins,Francislene Juliana; Hyaric,Mireille Le; Oliveira,Manoel Marques Evangelista; Macedo,Gilson Costa; Almeida,Mauro Vieira de; Raposo,Nádia Rezende Barbosa. |
| Abstract Onychomycosis is a fungal infection of the nail caused by high densities of filamentous fungi and yeasts. Treatment for this illness is long-term, and recurrences are frequently detected. This study evaluated in vitro antifungal activities of 12 organic compounds derived from amino alcohols against standard fungal strains, such as Trichophyton rubrum CCT 5507 URM 1666, Trichophyton mentagrophytes ATCC 11481, and Candida albicans ATCC 10231. The antifungal compounds were synthesized from p-hydroxybenzaldehyde (4a-4f) and p-hydroxybenzoic acid (9a-9f). Minimum inhibitory concentrations and minimum fungicidal concentrations were determined according to Clinical and Laboratory Standards Institute protocols M38-A2, M27-A3, and M27-S4. The amine series... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amino alcohols; Amides; Lipophilicity; Antifungal activity; Onychomycosis. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000300476 |
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| Registros recuperados: 45 | |
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