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	Provedor de dados Anais da ABC (AABC) (1) ArchiMer (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Andrade Junior,Heitor Franco de (1) BEZERRA,MARCOS A. (1) Borborema,Samanta Etel Treiger (1) CARDOZO,MANUELLE C. (1) CAVALCANTE,DANNUZA D. (1) Gil-diaz, Teba (1) Nascimento,Nanci do (1) Osso Junior,João Alberto (1) SANTOS,WALTER N.L. DOS (1) SILVA,DANIEL L.F. (1) Mais... Palavra-chave Antimony (3) Antimoine (1) Biodistribution (1) Cutaneous leishmaniasis (1) Estuaire de la Gironde (1) Extractions sélectives (1) Gironde Estuary (1) HG-AFS (1) Hair (1) Leishmaniasis (1) Meglumine antimoniate (1) Multivariate optimization (1) Partition solide/liquide (Kd) (1) Pharmacokinetics (1) Radioisotope (1) Selective extractions (1) Solid/liquid partitioning (Kd) (1) Tellure (1) Tellurium (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Text (1) Ano 2019 (2) 2016 (1) País Brazil (2) France (1) Idioma Inglês (2) Francês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Multivariate optimization of a method for antimony determination by hydride generation atomic fluorescence spectrometry in hair samples of patients undergoing chemotherapy against Leishmaniasis Anais da ABC (AABC) CARDOZO,MANUELLE C.; CAVALCANTE,DANNUZA D.; SILVA,DANIEL L.F.; SANTOS,WALTER N.L. DOS; BEZERRA,MARCOS A.. ABSTRACT A method was developed for determination of total antimony in hair samples from patients undergoing chemotherapy against Leishmaniasis based on the administration of pentavalent antimonial drugs. The method is based on microwave assisted digestion of the samples in a pressurized system, reduction of Sb5+ to Sb3+ with KI solution (10% w/v) in ascorbic acid (2%, w/v) and its subsequent determination by hydride generation atomic fluorescence spectrometry (HG-AFS). The proportions of each component (HCl, HNO3 and water) used in the digestion were studied applying a constrained mixtures design. The optimal proportions found were 50% water, 25% HNO3 and 25% HCl. Variables involved in the generation of antimony hydride were optimized using a Doehlert... Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmaniasis; Antimony; Hair; HG-AFS; Multivariate optimization. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401179 Comportement biogéochimique d'antimoine (Sb) et de tellure (Te) dans le milieu côtier : vers des scénarios de dispersion des radionucléides de Sb et de Te en cas de rejets accidentels de centrales nucléaires ArchiMer Gil-diaz, Teba. Antimony (Sb) and tellurium (Te) are relatively uncommon contaminants (stable isotopes) and may form short-lived fission products (radionuclides) released into the environment during nuclear power plants accidents. Little is known about their respective biogeochemical behaviours, necessary for general contamination studies and post-accidental radiological risk assessment.This work provides original knowledge on Sb and Te biogeochemical behaviour in highly dynamic continent-ocean transition systems: the Gironde Estuary and the Rhône River. Concentrations, spatial/temporal variations, solid/liquid partitioning (Kd), and fluxes are studied from long-term records at the watershed scale. Four estuarine sampling campaigns during contrasting hydrological... Tipo: Text Palavras-chave: Antimoine; Tellure; Estuaire de la Gironde; Partition solide/liquide (Kd); Extractions sélectives; Antimony; Tellurium; Gironde Estuary; Solid/liquid partitioning (Kd); Selective extractions. Ano: 2019 URL: https://archimer.ifremer.fr/doc/00607/71891/70592.pdf Pharmacokinetics of neutron-irradiated meglumine antimoniate in Leishmania amazonensis-infected BALB/c mice J. Venom. Anim. Toxins incl. Trop. Dis. Borborema,Samanta Etel Treiger; Osso Junior,João Alberto; Andrade Junior,Heitor Franco de; Nascimento,Nanci do. Abstract Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by the protozoan Leishmania spp. Pentavalent antimonial agents have been used as an effective therapy, despite their side effects and resistant cases. Their pharmacokinetics remain largely unexplored. This study aimed to investigate the pharmacokinetic profile of meglumine antimoniate in a murine model of cutaneous leishmaniasis using a radiotracer approach. Methods: Meglumine antimoniate was neutron-irradiated inside a nuclear reactor and was administered once intraperitoneally to uninfected and L. amazonensis-infected BALB/c mice. Different organs and tissues were collected and the total antimony was measured. Results: Higher antimony levels were found in infected than... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cutaneous leishmaniasis; Meglumine antimoniate; Pharmacokinetics; Biodistribution; Antimony; Radioisotope. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100304 Registros recuperados: 3 Primeira ... 1 ... Última

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