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| Registros recuperados: 22 | |
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| 豊留, 孝仁; TOYOTOME, Takahito. |
| Aspergillus species (spp.) are medically important pathogens that cause aspergillosis, and A. fumigatus is the most prevalent causative agent of the disease. Aspergillus spp. produce various secondary metabolites; however, the role of these metabolites in aspergillosis remains unclear. Gliotoxin is a major secondary metabolite produced by A. fumigatus. Several recent studies have reported that gliotoxin contributes to the virulence of A. fumigatus. Here I review studies related to gliotoxin and its contribution to the infection caused by A. fumigatus. |
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Palavras-chave: Aspergillosis; Aspergillus fumigatus; Gliotoxin; Secondary metabolite. |
| Ano: 2015 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4157 |
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| Xavier,Melissa O.; Soares,Mauro P.; Meinerz,Ana Raquel M.; Nobre,Márcia O.; Osório,Luiza G.; Silva Filho,Rodolfo P. da; Meireles,Mário Carlos A.. |
| The article describes the epidemiology, macroscopic and histological lesions as well as the isolation of Aspergillus flavus and A. fumigatus from Magellanic penguins (Spheniscus magellanicus) during recovery in the Center for Recovery of Marine Animals (CRAM - 32ºS/52ºW), over a period of two years. From January 2004 to December 2005 the Center received 52 Magellanic penguins, and 23% (12/52) died. Necropsies were performed and tissue samples were collected for histological and microbiological examination. From 12 dead animals, aspergillosis was confirmed in five animals, corresponding to 42% of the mortality. Granulomatous nodules were observed mainly on air sacs and lungs. Histologically, septate and branching hyphae,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aspergillosis; Rehabilitation; Penguins; Captivity. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000300018 |
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| Azarpira,Negar; Esfandiari,Majid; Bagheri,Mohamad Hadi; Rakei,Sed; Salari,Soheila. |
| Fungal infections of the central nervous system (CNS) are almost always a surprising finding. Their presentation is usually subtle, often without any diagnostic characteristics, and they are frequently mistaken for pyogenic abscesses, or brain tumors. Aspergillosis of the central nervous system is an uncommon infection, mainly occurring in immunocompromised patients. It may present in several forms, including meningitis, mycotic aneurysms, infarcts and a tumoral form. We report an intracranial granuloma due to Aspergillus fumigatus involving the anterior cranial fossa and the frontal lobe. The clinical symptoms began one year before admission. Final diagnosis was made after craniotomy. The patient was treated with an... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Granulomatous inflammation; Aspergillus fumigatus; Fungal infections. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400019 |
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| Hubka, V.; Barrs, V.; Dudová, Z.; Sklenář, F.; Kubátová, A.; Matsuzawa, T.; Yaguchi, T.; Horie, Y.; Nováková, A.; Frisvad, J.C.; Talbot, J.J.; Kolařík, M.. |
| Although Aspergillus fumigatus is the major agent of invasive aspergillosis, an increasing number of infections are caused by its cryptic species, especially A. lentulus and the A. viridinutans species complex (AVSC). Their identification is clinically relevant because of antifungal drug resistance and refractory infections. Species boundaries in the AVSC are unresolved since most species have uniform morphology and produce interspecific hybrids in vitro. Clinical and environmental strains from six continents (n = 110) were characterized by DNA sequencing of four to six loci. Biological compatibilities were tested within and between major phylogenetic clades, and ascospore morphology was characterised. Species delimitation... |
| Tipo: Article / Letter to the editor |
Palavras-chave: Aspergillus felis; Aspergillus fumigatus; Invasive aspergillosis; Mating-type genes; Multispecies coalescence model; Neosartorya udagawae; Scanning electron microscopy; Soil fungi. |
| Ano: 2018 |
URL: http://www.repository.naturalis.nl/record/652411 |
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| Peron,G.; Fernandes,F.F.; Landgraf,T.N.; Martinez,R.; Panunto-Castelo,A.. |
| Paracoccidioides brasiliensis and P. lutzii are fungi that cause paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in South America. For serological diagnosis, although 43-kDa glycoprotein (gp43) is regarded as highly specific for PCM, the occurrence of false negative reactions in sera from patients infected with P. lutzii suggests that preparation with only one antigen is not recommended. Heat shock proteins are feasible alternatives as a second antigen because they are often highly immunogenic. In this study, we evaluated the usefulness of recombinant 60-kDa heat shock protein from P. brasiliensis (rPbHsp60) for the serological diagnosis of PCM. Using western blotting assay, we observed that 77.3% of the sera from PCM patients were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Paracoccidioidomycosis; Heat shock protein; Serodiagnosis; ELISA; Western blotting. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000400705 |
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| Brandão,Ildnay de Souza Lima; Oliveira-Moraes,Heloiza Maria da Silva; Motta,Cristina Maria de Souza; Oliveira,Neiva Tinti de; Magalhães,Oliane Maria Correia. |
| Abstract Aspergillus fumigatus is an opportunistic saprobe fungus that accounts for 90% of cases of pulmonary aspergillosis in immunosuppressed patients and is known for its angiotropism. When it reaches the respiratory tract, A. fumigatus interacts with structural components and blood vessels of the lungs, such as elastin. To understand the effect of this structural component, we examined the effect of elastin on the production and development of the biofilm of A. fumigatus. In RPMI containing 10 mg/mL of elastin, a significant increase (absorbance p < 0.0001; dry weight p < 0.0001) in the production of biofilm was observed in comparison to when RPMI was used alone, reaching a maximum growth of 18.8 mg (dry weight)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aspergillus fumigatus; Biofilm; Elastin; Extracellular matrix; Hydrophobicity. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000300675 |
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| Moreira,Ana Carolina Pessoa; Lima,Edeltrudes de Oliveira; Wanderley,Paulo Alves; Carmo,Egberto Santos; Souza,Evandro Leite de. |
| This study aimed to identify the constituents of the essential oil from Hyptis suaveolens (L.) leaves using a Gas Chromatograph -Mass Spectrometer and assess its inhibitory effect on some potentially pathogenic Aspergilli (A. flavus, A. parasiticus, A. ochraceus, A. fumigatus and A. niger). Eucaliptol (47.64 %) was the most abundant component in the oil, followed for gama-ellemene (8.15 %), beta-pynene (6.55 %), (+)3-carene (5.16 %), trans-beta-cariophyllene (4.69 %) and germacrene (4.86 %). The essential oil revealed an interesting anti-Aspergillus property characterized by a Minimum Inhibitory Concentration and Minimum Fungicidal Concentration of 40 and 80 µL/mL, respectively. The oil at 80 and 40 µL/mL strongly inhibited the mycelial growth of A.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hyptis suaveolens L. (Poit); Essential oil; Anti-Aspergillus effect. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000100006 |
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| Denardi,Laura Bedin; Hoch Dalla-Lana,Bianca; Pantella Kunz de Jesus,Francielli; Bittencourt Severo,Cecília; Santurio,Janio Morais; Zanette,Régis Adriel; Alves,Sydney Hartz. |
| ABSTRACT The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Following the EUCAST-proposed breakpoints, 20% and 25% of the clinical and environmental isolates of A. fumigatus, respectively, were found to be resistant to itraconazole (Minimal Inhibitory Concentration, MIC > 2.0 mg/L). Voriconazole showed good activity against A. fumigatus and A. flavus strains, except for one clinical strain of A. fumigatus whose MIC was 4.0 mg/L. Posaconazole (≤0.25 mg/L) also showed appreciable activity... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aspergillus flavus; Aspergillus fumigatus; Echinocandins; Azoles; Environmental; Susceptibility. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100030 |
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| Registros recuperados: 22 | |
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