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| Registros recuperados: 62 | |
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| Ishii, Toshiaki; Furuoka, Hidefumi; Muroi, Yoshikage; Nishimura, Masakazu; 石井, 利明; 古岡, 秀文; 室井, 喜景. |
| Integrin-linked kinase (ILK) is a focal adhesion serine/ threonine protein kinase with an important role in integrin and growth factor signaling pathways. Recently, we demonstrated that ILK is expressed in N1E-115 neuroblastoma cells and controls integrin-dependent neurite outgrowth in serum-starved cells grown on laminin (Ishii, T., Satoh, E., and Nishimura, M. ( 2001) J. Biol. Chem. 276, 42994 - 43003). Here we report that ILK controls tau phosphorylation via regulation of glycogen synthase kinase-3beta (GSK-3beta) activity in N1E-115 cells. Stable transfection of a kinase-deficient ILK mutant (DN-ILK) resulted in aberrant tau phosphorylation in N1E-115 cells at sites recognized by the Tau-1 antibody that are identical to some of the phosphorylation... |
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Palavras-chave: ALZHEIMERS-DISEASE NEURITE OUTGROWTH PROTEIN; NEURONS HYPERPHOSPHORYLATION KINASE-3-BETA ACCUMULATION BINDING ROLES. |
| Ano: 2003 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/747 |
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| 松山, 雄喜; 神尾, 恭平; 村上, 智亮; 下田, 崇; 古林, 与志安; 古岡, 秀文; 松本, 高太郎; 猪熊, 壽; MATSUYAMA, Yuuki; KAMIO, Kyouhei; MURAKAMI, Tomoaki; SHIMODA, Takashi; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; MATSUMOTO, Kohtaro; INOKUMA, Hisashi. |
| 5 歳6 カ月齢ホルスタイン種乳牛が，後躯麻痺による起立不能を呈した．浅頸リンパ節の腫大と直腸検査による腫瘤 の触知から牛白血病を疑ったが，血液検査とリンパ節の針吸引生検では確定診断できなかった．剖検では，60 × 40 × 20cm 大の多結節性腫瘤が背側の腹腔壁に接して存在していた．腫瘍組織は腸腰筋に浸潤し，一部は第5 および第6 腰 椎椎間孔より脊柱管内に連続的に波及し，脊髄および脊髄神経根を圧迫していた．腫瘍はCD3 陽性のT細胞性リンパ 腫で，牛白血病ウイルス抗体陰性であったため，散発型牛白血病と診断された． A Holstein cow (5 years and 3 months old) presented with hind limb paresis and was unable to stand. Bovine leukosis was suspected given the enlargement of cervical lymph nodes and existence of an abdominal mass detected by rectal palpation; however，it could not be confirmed by blood examination and fine needle aspiration of cervical lymph nodes. Pathological examination revealed a mu1tinodular mass (60 x 40 x 20 cm) on the dorsal abdomen that was invasive into the iliopsoas muscle. A portion of the... |
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Palavras-chave: 牛白血病; 脊髄浸潤; 後躯麻痺; Bovine leukosis; Spinal cord invasion; Hind limb paresis. |
| Ano: 2009 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2809 |
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| HORIUCHI, Noriyuki; KUMAGAI, Daishiro; MATSUMOTO, Kotaro; INOKUMA, Hisashi; FURUOKA, Hidefumi; KOBAYASHI, Yoshiyasu; 松本, 高太郎; 猪熊, 壽; 古岡, 秀文; 古林, 与志安. |
| Bovine dilated cardiomyopathy (DCM) is an autosomal recessive genetic disorder causing congestive heart failure and subsequent death. Recently, a nonsense mutation c.343C>T in the bovine optic atrophy 3 (OPA3) gene had been reported to cause the DCM in Holstein cattle in Switzerland. However, the mutation has not been confirmed in bovine DCM outside Switzerland. Nine Holstein Friesian cows that were macroscopically and histologically diagnosed with or suspected of DCM and 12 control cows kept in Japan were tested for the mutation. The mutation surrounding OPA3 DNA fragment was amplified by PCR and subjected to direct sequences. The homogeneous c.343C>T mutation was proved to occur in all the affected cows and not in the control cows. The present... |
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Palavras-chave: Cattle; Dilated cardiomyopathy; Nonsense mutation; OPA3 gene. |
| Ano: 2015 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4208 |
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| 久保田, 直樹; 村上, 智亮; 安田, 峰; 松井, 基純; 古林, 与志安; 古岡, 秀文; 松井, 高峯; 佐々木, 直樹; 石井, 三都夫; 猪熊, 壽. |
| 19歳齢のペルシュロン種繁殖雌馬に血尿が認められた。血尿は止血剤および抗生剤投与によっては改善され なかった。患畜は次第に元気食欲の低下、削痩、貧血を呈し、高度蛋白尿および胸前部冷性浮腫が発現した。 直腸検査により人頭大に腫大した左腎を触知し、腎臓腫瘍を疑った。病理解剖の結果、左腎は27X18Xl0cmに 腫大し、血液に富む巨大な腫瘤形成(13X8X8cm)を認めた。左腎門リンパ節は腫大し、また右腎臓、左右 副腎、肝臓および肺では大小の白色腫瘤を認めた。病理組織学的検査によりこれらの腫瘍はいずれも浸潤性に 増殖する上皮性腫瘍組織であったことから、本症例は腎細胞癌が他の複数の臓器に転移したものと考察した。 |
| Ano: 2011 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2935 |
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| 猪熊, 壽; 滄木, 孝弘; 松本, 高太郎; 堀内, 雅之; 古林, 与志安; 古岡, 秀文; INOKUMA, Hisashi; AOKI, Takahiro; MATSUMOTO, Kotaro; HORIUCHI, Noriyuki; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi. |
| Ano: 2015 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4145 |
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| 滄木, 孝弘; 佐藤, あかね; 坂田, 貴洋; 山本, 修治; 伊藤, 博義; 古林, 与志安; 古岡, 秀文; 松井, 高峯; 石井, 三都夫; 猪熊, 壽. |
| 放牧中のl歳7カ月齢ホルスタイン種育成午が、発熱、頻脈、心音強勢、収縮期雑音、頚静脈怒張、肺音粗 励、右後肢跛行の症状を呈した。心臓超音波検査により肺動脈弁に付着する疣贅物、心室中隔欠損、大動脈騎 乗などの所見が得られた。病理解剖検査では、これらの所見のほかに右後肢の関節炎が確認され、心室中隔欠 損と大動脈騎乗の心奇形個体に関節炎由来の細菌性心内膜炎を併発したものと考えられた。肺動脈弁の疣贅物からは嫌気培養によりPeptostreptococcus anaerobiusが分離された。 |
| Ano: 2009 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2792 |
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| 立石, 識子; 古林, 与志安; 黒沢, 重人; 大林, 哲; 古岡, 秀文; 松井, 高峯; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi. |
| 直腸検査により, 左腎相当部に巨大腫瘤が触知された4歳齢, 雌のホルスタイン牛を病理学的に検索した. 肉眼的に左腎は硬く, 褪色し, 分葉構造を保ちつつ顕著に腫大していた. 左腎割面では腎実質の大部分は白色硬組織により置換されていた. また, 左腎門リンパ節から左内腸骨リンパ節にかけて直径1-10cmの白色硬組織からなる腫瘤が密在していた. 組織所見では左腎に著しい結合組織増生を伴う上皮性腫瘍細胞の不整管状増殖がび漫性に認められ, 実質を置換していた. 同様の腫瘍組織は他の白色硬組織でも観察された. これらの腫瘍細胞は抗ウロモジュリン抗体に陽性を示した. 超微形態学的に腫瘍細胞には微絨毛とデスモゾームが認められた. 以上の所見から本症例を顕著な結合組織の増生を伴う腎細胞癌と診断した. |
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Palavras-chave: 牛; 腎細胞癌; ウロモジュリン. |
| Ano: 2005 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4171 |
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| MAGATA, Fumie; ISHIDA, Yoshikazu; MIYAMOTO, Akio; FURUOKA, Hidefumi; INOKUMA, Hisashi; SHIMIZU, Takashi; 宮本, 明夫; 古岡, 秀文; 猪熊, 壽; 清水, 隆. |
| We investigated the concentration of the bacterial endotoxin lipopolysaccharide (LPS) in the blood, ovarian follicular fluid and uterine fluid of a clinical case of bovine metritis. A 2-year-old lactating Holstein cow exhibited continuous fever >39.5°C for more than 2 weeks after normal calving. The cow produced a fetid, watery, red-brown uterine discharge from the vagina and was diagnosed with metritis. The LPS concentrations in plasma and uterine fluid were 0.94 and 6.34 endotoxin units (EU)/ml, respectively. One of seven follicles showed an extremely high level of LPS (12.40 EU/ml) compared to the other follicles (0.62–0.97 EU/ml). These results might suggest the presence of high concentration of LPS in follicles in cows with postpartum metritis. |
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Palavras-chave: Dairy cow; Follicle; Lipopolysaccharide; Metritis. |
| Ano: 2015 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4043 |
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| CHIBA, Shiori; FUNATO, Shingo; HORIUCHI, Noriyuki; MATSUMOTO, Kotaro; INOKUMA, Hisashi; FURUOKA, Hidefumi; KOBAYASHI, Yoshiyasu; 堀内, 雅之; 松本, 高太郎; 猪熊, 壽; 古岡, 秀文; 古林, 与志安. |
| Degeneration of the optic pathway has been reported in various animal species including cattle. We experienced a case of bilateral optic tract degeneration characterized by severe gliosis in a Japanese black cattle without any obvious visual defects. To evaluate the significance, pathological nature and pathogenesis of the lesions, we examined the optic pathway in 60 cattle (41 Japanese black, 13 Holstein and 6 crossbreed) with or without ocular abnormalities. None of these animals had optic canal stenosis. Degenerative changes with severe gliosis in the optic pathway, which includes the optic nerve, optic chiasm and optic tract, were only observed in 8 Japanese black cattle with or without ocular abnormalities. Furthermore, strong immunoreactivity of... |
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Palavras-chave: Axonal degeneration; Gliosis; Japanese black cattle; Optic pathway degeneration. |
| Ano: 2015 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4123 |
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| YAMADA, Manabu; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; MATSUI, Takane; 古林, 与志安; 古岡, 秀文. |
| Autumn crocus poisoning of cattle is characterized by severe diarrhea caused by alkaloid colchicine. Previously, we examined pathologically this poisoning in cattle and reported that enterotoxic lesions were closely associated with apoptosis. To examine enterotoxicity of autumn crocus more precisely, a reproductive study was performed using guinea pigs and mice, and pathological findings associated with autumn crocus poisoning were compared with those of colchicine. Each group of guinea pigs given the bulb of autumn crocus or colchicine exhibited severe diarrhea. Histopathological findings in intoxicated guinea pigs were entirely consistent with those in the autumn crocus-poisoned cattle. In contrast, each group of mice administered with the bulb or... |
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Palavras-chave: Apoptosis; Autumn crocus (Colchicum autumnale L.); Colchicine; Guinea pig; Mouse. |
| Ano: 2000 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4170 |
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| Registros recuperados: 62 | |
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