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| HERRMANN,SONJA; SCHÜBEL,TABEA; COSTA,FANNY N.; BARBOSA,MARIA LETÍCIA C.; FERREIRA,FABIO F.; DIAS,THAYS L.M.F.; ARAÚJO,MORGANA V.; ALEXANDRE-MOREIRA,MAGNA S.; LIMA,LÍDIA M.; LAUFER,STEFAN; BARREIRO,ELIEZER J.. |
| ABSTRACT N-acylhydrazone is an interesting privileged structure that has been used in the molecular design of a myriad of bioactive compounds. In order to identify new antinociceptive drug candidates, we described herein the design, synthesis, X-ray diffraction study and the pharmacological evaluation of a series of 3-amino-4-methylthiophene-2-acylcarbohydrazone derivatives (8a-t). Compounds were prepared in good overall yields through divergent synthesis from a common key intermediate and were characterized by classical spectroscopy methods. X-ray diffraction study was employed for unequivocal determination of the imine double bond stereochemistry. 8a-t were evaluated in vivo through oral administration using the classical writhing test in mice.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: N-acylhydrazone; Privileged structure; Antinociceptive; P38MAPK; X-ray. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301073 |
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