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| Yousaf,Abid Mehmood; Malik,Usman Rashid; Shahzad,Yasser; Hussain,Talib; Khan,Ikram Ullah; Din,Fakhar Ud; Mahmood,Tariq; Ahsan,Hafiz Muhammad; Syed,Ahmed Shah; Akram,Muhammad Rouf. |
| Abstract The aim of the present research was to develop a silymarin-laden PVP-nanocontainer providing ameliorated aqueous solubility and dissolution of the drug. Several silymarin-laden formulations were formed with varying quantities of PVP and SDS via the solvent evaporation method using the electrospraying technique. The influence of the hydrophilic carriers on solubility and dissolution was explored. The solid-state characterization was carried out by particle-size analysis, PXRD, DSC, FTIR and SEM. All of the formulations demonstrated better solubility and dissolution than did silymarin plain powder. Both the SDS and PVP had positive effects on solubility and dissolution of silymarin in the aqueous media. An increased solubility was attained as the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Silymarin; Electrospraying; PVP-nanocontainers; Aqueous solubility; Dissolution. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100612 |
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