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Assessment of the Toxicity of Sub-chronic Low and High Doses of the Bio-insecticide Spinosad on the Liver, Kidney and the Cerebellum in Male Albino Mice BABT
El-Naggar,Sabry A; Eltantawi,Hala; Ibrahim,Mahrous A; Alm-Eldeen,Abeer.
ABSTRACT Spinosad (SPD) is a highly selective insect control product. However, it was reported that SPD has toxicity toward other non-target organisms. This study was conducted to address the toxic effect of two sub-chronic low and high doses; 35 and 350 mg/kg SPD on some biochemical, histological and immunohistochemical parameters of the liver, kidney and cerebellum. Thirty-six male Swiss mice were divided into three groups of 12 mice each; first group (G1) served as a control, second group (G2) received a low sub-chronic dose of SPD that is equal to 35 mg/kg, and third group (G3) received a high sub-chronic dose of SPD that is equal to 350 mg/kg. The results showed that mice which were received 350 mg/kg SPD showed a significant decrease in the body...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bio-insecticide; Spinosad; Toxicity; Sub-chronic; Biochemical; Histological; Immunohistochemical; Alterations.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100306
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Quercetin modulates age-induced changes in the transcript levels of some apoptosis related genes in the skeletal muscles of male rats BJPS
Alm-Eldeen,Abeer; Khamis,Abeer; Elfiky,Nabil; Ahmad,Randa.
Adverse changes occur gradually in the skeletal muscles with age via continuous exposure to oxidative stress. Quercetin, a member of the flavonoids family, possesses anti-oxidative and radical-scavenging activities. Therefore, this study investigated the role of quercetin to modulate age-induced changes in the transcript levels of some apoptosis-related genes in rat’s gastrocnemius muscles, up to 15 months-old. Half of the rats at each age (1, 5, 10 and 15 months old) were given a vehicle and the other half was given 200 mg/kg quercetin for 2 weeks, respectively. With the increase of age, vehicle groups showed hyalinization of the muscle fibers and a decrease of the catalase and an increase of the malondialdehyde levels. Down-regulation of Bcl2 gene and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Quercetin Age; Bcl2 Bax NF-KB Apoptosis Caspace3 Catalase MDA Histopathology.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100638
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