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Comparative study of sustained-release lipid microparticles and solid dispersions containing ibuprofen 60
Almeida,Hugo; Amaral,Maria Helena; Lobão,Paulo.
Ibuprofen is one of the most important non-steroidal anti-inflammatory drugs used in the treatment of inflammatory diseases. In its pure state, ibuprofen presents poor physical and mechanical characteristics and its use in solid dosage forms needs the addition of excipients that improve these properties. The selection of the best excipients and the most suitable pharmaceutical dosage form to carry ibuprofen is very important for the industrial success of this drug. Given these factors, lipid microparticles and solid dispersions of ibuprofen with cetyl alcohol, stearic acid, and hydrogenated castor oil were prepared. These formulations were intended to improve the physical and mechanical characteristics and to sustain the release of this drug. Physical...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ibuprofen/solid dispersions; Ibuprofen/release profile; Ibuprofen/lipid microparticles; Ibuprofen/release profile; Excipients; Cetyl alcohol; Stearic acid; Hydrogenated castor oil.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300020
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Drugs obtained by biotechnology processing 60
Almeida,Hugo; Amaral,Maria Helena; Lobão,Paulo.
In recent years, the number of drugs of biotechnological origin available for many different diseases has increased exponentially, including different types of cancer, diabetes mellitus, infectious diseases (e.g. AIDS Virus / HIV) as well as cardiovascular, neurological, respiratory, and autoimmune diseases, among others. The pharmaceutical industry has used different technologies to obtain new and promising active ingredients, as exemplified by the fermentation technique, recombinant DNA technique and the hybridoma technique. The expiry of the patents of the first drugs of biotechnological origin and the consequent emergence of biosimilar products, have posed various questions to health authorities worldwide regarding the definition, framework, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Biotechnology; Recombinant DNA; Hybridoma technique; Bacteria; Antibiotics; Vaccines.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200002
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Use of solid dispersions to increase stability of dithranol in topical formulations 60
Estanqueiro,Marilene; Conceição,Jaime; Amaral,Maria Helena; Lobo,José Manuel Sousa.
The present study was planned to improve the stability of dithranol using solid dispersions (SD). Two different SD at a 1:9 ratio of dithranol/excipient were prepared: one of them using glyceryl behenate as excipient and the other using a mixture of argan oil with stearic acid (1:8 ratio) as excipient. Pure dithranol and SD of dithranol were incorporated in an oil-in-water cream and in a hydrophobic ointment in a drug/dermatological base ratio of 1:10. The physical and mechanical properties of semisolid formulations incorporating the pure drug and the developed SD were evaluated through rheological and textural analysis. To evaluate the stability, L*a*b* color space parameters of SD and semisolid formulations, and pH of hydrophilic formulations were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dithranol/stability; Topical formulations/development; Solid dispersions/preparation; Stearic acid; Glyceryl behenate; Argan oil.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300583
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Characterization and stability studies of emulsion systems containing pumice 60
Estanqueiro,Marilene; Conceição,Jaime; Amaral,Maria Helena; Santos,Delfim; Silva,João Baptista; Lobo,José Manuel Sousa.
Emulsions are the most common form of skin care products. However, these systems may exhibit some instability. Therefore, when developing emulsions for topical application it is interesting to verify whether they have suitable physical and mechanical characteristics and further assess their stability. The aim of this work was to study the stability of emulsion systems, which varied in the proportion of the emulsifying agent cetearyl alcohol (and) sodium lauryl sulfate (and) sodium cetearyl sulfate (LSX), the nature of the oily phase (decyl oleate, cyclomethicone or dimethicone) and the presence or absence of pumice (5% w/w). While maintaining the samples at room temperature, rheology studies, texture analysis and microscopic observation of formulations...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Emulsions/topical use/stability study; Emulsions/topical use/characterization; Pumice/presence in emulsions; Emulsions/texture; Emulsions/rheology; Emulsions/spreadability.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200361
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