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| Amna,Touseef; Amina,Musarat; Sharma,P.R.; Puri,S.C.; Al-Youssef,Hanan M.; Al-Taweel,Areej M.; Qazi,G. N.. |
| We have established methodology for the isolation and characterization of a novel endophytic fungus from the inner bark of medicinal plant Nothapodytes foetida, which produced camptothecin in Sabouraud broth (SB) under shake flask conditions. Camptothecin and its related compounds are at present obtained by extraction from intact plants, but fungal endopytes may be an alternative source of production. In present study we have observed the effect of different nutrient combinations and precursors (tryptophan, tryptamine, geraniol, citral, mevalonic acid and leucine) on the accumulation of camptothecin by endophytic fungus Entrophospora infrequens. The precursors were fed either alone or in combinations (tryptophan and geraniol, tryptophan and citral,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Camptothecin; Entrophospora infrequens; Cancer; Nothapodytes foetida; Precursors. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000400032 |
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