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| Rodrigues,Patrícia A.; Morais,Selene M.; Souza,Carolina M.; Magalhães,Davi V.; Vieira,Ícaro G.P.; Andrade,Geanne M.; Rao,Vietla S.; Santos,Flávia A.. |
| Byrsonima sericea leaves are extensively used in folk medicine in Brazil against gastric disorders. This study investigated the chemical constituents of B. sericea leaf ethanolic extract (BSLE) and its potential gastroprotective activity, with its possible mechanism of the action using ethanol to induce gastric mucosal damage in mice. The phytochemical analysis was carried out to identify the active constituents present in the extract, and the HPLC analysis was performed for the identification of flavonoids. BSLE at oral doses of 125, 250 and 500 mg/kg markedly attenuated the ethanol-evoked gastric lesions by 53.2, 84.9 and 87.6 %, respectively. The BSLE (250 mg/kg) prevented the depletion of gastric mucus and gastric mucosal nonproteic-sulfhydryl groups,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antioxidant; Byrsonima sericea; Flavonoids; Gastroprotection; Mechanisms of action. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000100011 |
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