Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJPS (5) BABT (2) Autor Andreazza,Itamar Francisco (7) Goebel,Karin (2) Murakami,Fábio Seigi (2) Souza,Dayse Fernanda de (2) Déo,Simone Cristina (1) Ferraz,Humberto Gomes (1) Galan,Vanderson (1) Martins,Sarah Moherdaui (1) Müller,Vinicius (1) Possamai,João Carlos (1) Rosa,Maurício Ferreira da (1) Sato,Mayumi Elisa Otsuka (1) Sato,Mayumi Eliza Otsuka (1) Souza,Fabio Pinheiro de (1) Tondo Filho,Volnei Jose (1) Wypych,Thaiz Cristina (1) Mais... Palavra-chave Drugs/modified release (2) Pellets (2) Biphasic Release (1) Buccoadhesive systems (1) Cellulosic Polymers (1) Chronotherapy (1) Coated pellets/dissolution profile (1) Coated pellets/evaluation (1) Coating (1) Controlled release (1) Diclofenac diethylamine/gel (1) Diclofenac sodium (1) Enteric release mini-tablets/development (1) Enteric release mini-tablets/evaluation (1) Experimental Design (1) Extrusion spheronization (1) Extrusion- Spheronisation/pellets obtention (1) Generic semisolid drug products (1) Guar gum (1) Hydroxypropylmethyl cellulose (1) Mais... Tipo do documento Info:eu-repo/semantics/article (7) Ano 2018 (1) 2014 (1) 2013 (2) 2011 (3) País Brazil (7) Idioma Inglês (7)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 7 Primeira ... 1 ... Última Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat® SR 30D BABT Andreazza,Itamar Francisco; Ferraz,Humberto Gomes. The aim of this study was to prepare and evaluate the pellets, containing a highly soluble drug (ascorbic acid), by the extrusion-spheronization process and coated with a release controlling polymer. The coating (undertaken in a fluid bed) was applied to three batches of the pellets with a dispersion of Kollicoat® SR 30 D, with each batch of pellets receiving a different level of polymer (5.07; 8.26 and 10.35%). The coated pellets were evaluated for sphericity by imaging analysis and comparative dissolution profile with a product commercially available in Brazil. All of the evaluated samples presented adequate physical properties and the dissolution profile of those coated with 5.07% of polymer proved to be similar to that of the commercially available... Tipo: Info:eu-repo/semantics/article Palavras-chave: Coating; Pellets; Extrusion spheronization; Controlled release. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200013 Development and evaluation of a hydrophilic matrix as a buccoadhesive system containing diclofenac sodium BABT Wypych,Thaiz Cristina; Andreazza,Itamar Francisco. The aim of this work was to study the development and evaluation of a hydrolphilic matrix as a buccoadhesive system containing diclofenac sodium. Eleven formulations were prepared containing the following bioadhesive polymers: hydroxylpropylmethylcellulose, polycarbophil, guar gum and xanthan gum individually and in combination. All the formulations were evaluated for the swelling index, adhesive index, and the time of adhesive and drug release profile (%). The results showed that the formulations that presented the most swelling index were the F3 (PAA/GX) and F6 (GG/GX). The smaller index swelling was for F1 (PAA/CM) and F10 (HPCMC/CM). The F4 (PAA/HPMC) formulation presented the best adhesive index and F10 (HPMC/CM) the worst. F1 (PAA/CM) was the best... Tipo: Info:eu-repo/semantics/article Palavras-chave: Diclofenac sodium; Buccoadhesive systems; Guar gum; Xantan gum; Hydroxypropylmethyl cellulose; Polycarbophil. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500006 Development of mesalazine pellets coated with methacrylic-derived polymer BJPS Déo,Simone Cristina; Andreazza,Itamar Francisco; Possamai,João Carlos. Mesalazine (5-ASA) is the standard drug for the treatment of inflammatory bowel disease (IBD) due to its local effect on intestinal and colonic mucosa. The effective and safe treatment of this disease requires more efficient delivery of the active substance to its site of action. The focus of this study was the use of multiparticulate systems, a modified release form in which the drug is divided into several functional subunits of release in the form of granules or pellets. When these forms are administered, they are rapidly disintegrated, distributing their content throughout the gastrointestinal tract. The aim of this study was to develop and evaluate a multiparticulate system consisting of pellets coated with polymer for pH-dependent release, derived... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mesalazine; Coated pellets/evaluation; Coated pellets/dissolution profile; Extrusion- Spheronisation/pellets obtention; Drugs/modified release. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100013 Development of a multiparticulate system containing enteric-release mini-tablets of omeprazole BJPS Tondo Filho,Volnei Jose; Andreazza,Itamar Francisco; Sato,Mayumi Elisa Otsuka; Murakami,Fábio Seigi. The main aim of this study was to develop a multiparticulate system containing mini-tablets of omeprazole formulated with an enteric polymer with pH-dependent solubility. Pre-formulation studies showed good flow and compaction capacity, leading to the production ofhigh quality mini-tablets. The mini-tablets were coated in a fluidized bed with hydroxypropylmethylcellulose /Eudragit(r) L30D55 and packed into hard gelatin capsules. The dissolution profile showed gastro-resistance and zero-order kinetics. The dissolution profile for the formulation containing lactose as the diluent and coated with 12% (tablet weight gain) of polymer was similar to that ofthe reference drug. Tipo: Info:eu-repo/semantics/article Palavras-chave: Multiparticulate system/modified release; Enteric release mini-tablets/development; Enteric release mini-tablets/evaluation; Omeprazole/dissolution. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300505 Development and evaluation of multiparticulate biphasic system for the treatment of circadian diseases BJPS Martins,Sarah Moherdaui; Müller,Vinicius; Galan,Vanderson; Souza,Fabio Pinheiro de; Andreazza,Itamar Francisco; Rosa,Maurício Ferreira da. Multiparticulate systems have biopharmaceutical advantages when compared to the monolithic systems, once they allow different patterns of drug release and can be used in different treatments. The aim of the present work was to develop a biphasic controlled release delivery system, using propranolol hydrochloride (PROP) that can be used for the treatment of circadian diseases. This system was obtained by the combination of cellulosic polymers hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC) in a 2² factorial experimental design, which allowed the optimization of the development stage. The pellets produced and used in biphasic formulations were evaluated for physical and chemical characteristics and presented acceptable results. The immediate... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronotherapy; Biphasic Release; Pellets; Cellulosic Polymers; Experimental Design. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400607 Development of enteric coated sustained release minitablets containing mesalamine BJPS Souza,Dayse Fernanda de; Goebel,Karin; Andreazza,Itamar Francisco. The aim of this study was to develop and evaluate a multiparticulate modified release system, composed of minitablets with a sustained release matrix system coated with a pH-dependent release polymer, using mesalamine as a model drug. Polyox® WSR 1105 was the polymer used in the matrix system and Eudragit® L30D55 was used as a pH-dependent polymer. The minitablets (with 20%, 30% or 40% Polyox® concentration) were prepared by dry granulation, which led to good quality minitablets. The developed minitablets were coated in a fluidized bed at 8% of the coating level. Dissolution studies were performed in media that simulated the gastrointestinal tract (pH 1.4, 6.0 and 7.2) and showed that formulations with higher Polyox® concentrations were capable of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mesalamine/modified release; Mesalamine/evaluation; Minitablets coated/modified release; Minitablets coated/evaluation; Polyethylene oxide/drugs coating; Drugs/modified release. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300014 In vitro release of diclofenac diethylamine from gels: evaluation of generic semisolid drug products in Brazil BJPS Goebel,Karin; Sato,Mayumi Eliza Otsuka; Souza,Dayse Fernanda de; Murakami,Fábio Seigi; Andreazza,Itamar Francisco. In order for the pharmacological action of a topical dermal drug product to occur, the drug must first be released from the vehicle to be available to penetrate the skin layers and reach the site of action. Drug release is mainly dependent on the characteristics of the formulation. Currently, to register a generic or a similar drug product in Brazil performance testing of topical drug products for local action is not required. In this context, this aim of this study was to evaluate the in vitro release of commercial diclofenac diethylamine gel products available on the Brazilian pharmaceutical market, using the vertical diffusion cell method. Factors which may influence the test, such as the type of membrane used, and the effect of the formulation... Tipo: Info:eu-repo/semantics/article Palavras-chave: In vitro release test; Diclofenac diethylamine/gel; Synthetic membranes; Generic semisolid drug products. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200003 Registros recuperados: 7 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco