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| Lung-Hao Tai; Anthony M. Zador. |
| How does attention modulate sensory representations? In order to probe the underlying neural mechanisms, we established a simple rodent model of modality-specific attention. Rats were trained to perform distinct auditory two-tone discrimination and olfactory odor discrimination in a two alternative choice (2AC) paradigm. 
To determine auditory cortex’s role in this frequency discrimination task, we used GABA-A receptor agonist muscimol to transiently and reversibly inactivate auditory cortexes bilaterally in rats performing simple interleaved auditory and olfactory discrimination. With olfactory discrimination performance serving as internal control for motivation and decision making capability, we found only auditory two-tone... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2355/version/1 |
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| Santiago Jaramillo; Anthony M. Zador. |
| When events occur at predictable instants, anticipation improves performance. Knowledge of event timing modulates motor circuits, improving response speed. By contrast, the neuronal mechanisms underlying changes in sensory perception due to expectation are not well understood. We have developed a novel behavioral paradigm for rats in which we manipulated expectations about sound timing. Valid expectations improved both the speed and the accuracy of subjects' performance, indicating not only improved motor preparedness but also enhanced perception. Single neuron recordings in primary auditory cortex revealed enhanced representation of sounds during periods of heightened expectation. Furthermore, we found that activity in auditory cortex was... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5139/version/1 |
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| Hiroki Asari; Anthony M. Zador. |
| Acoustic processing requires integration over time. However classical linear encoding models, which typically integrate over a few hundred milliseconds, have failed to account fully for neural responses in the auditory cortex. We have used in vivo intracellular recording to measure neuronal integration times in anesthetized rats. Probing with natural sounds and other stimuli, we found that context-dependent effects in the primary auditory cortex could last for surprisingly long, up to four seconds or longer in some neurons. Thalamic neurons showed only a much faster form of adaptation, indicating that the long-lasting form originated in the cortex. Restricting knowledge of the stimulus history to only a few hundred milliseconds reduced the predictable... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2282/version/1 |
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| Lung-Hao Tai; Anthony M. Zador. |
| How does attention modulate sensory representations? In order to probe the underlying neural mechanisms, we established a simple rodent model of modality-specific attention. Here we describe results of experiments in freely moving rats in which we have used tetrodes to record neural responses in primary auditory cortex (area A1) while subjects performed this behavior.

Subjects were first trained to perform distinct auditory and olfactory two alternative forced-choice (2AFC) tasks. Training and testing were conducted in a custom three-poke computer-controlled behavioral apparatus. Subjects initiated trials with a center-poke, which triggered presentation of a tone (either 5 or 15 Hz), an odor (either R(-)-2-Octanol or... |
| Tipo: Poster |
Palavras-chave: Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2354/version/1 |
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