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	Provedor de dados BJPS (2) Autor Araujo,Bibiana Verlindo de (2) Beck,Ruy Carlos Ruver (1) Chaves,Paula dos Santos (1) Cordenonsi,Leticia Malgarim (1) Fontana,Márcia Camponogara (1) Forgearini,Betielli (1) Laureano,João Víctor (1) Sponchiado,Rafaela Martins (1) Volpato,Nadia Maria (1) Wingert,Nathalie Ribeiro (1) Mais... Palavra-chave Acyclovir/pharmaceutical equivalence. (1) Acyclovir/semisolid formulations (1) Acyclovir/skin penetration/in vitro studies (1) Bioavailability. (1) Liquid chromatography. (1) Plasma. (1) Raloxifene/pharmacokinetic (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2016 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última In vitro evaluation of cutaneous penetration of acyclovir from semisolid commercial formulations and relation with its effective antiviral concentration BJPS Sponchiado,Rafaela Martins; Cordenonsi,Leticia Malgarim; Wingert,Nathalie Ribeiro; Araujo,Bibiana Verlindo de; Volpato,Nadia Maria. ABSTRACT The evaluation of drug permeation/penetration of semisolid formulations into animal skin can be useful to supplement the pharmaceutical equivalence. This paper describes the in vitro assessment of acyclovir (ACV) into porcine skin from commercial formulations with etermination of drug concentration in different layers of cutaneous tissue to correlate with effective antiviral concentration in order to improve the equivalence decision. Studies were conducted using Franz cells and porcine skin. Selected pharmaceutical creams containing ACV had identical (reference and generic) and different (similar) excipients. A software program was employed for the simulation of antiviral effectiveness in the skin. Regarding ACV skin penetration, the first batch... Tipo: Info:eu-repo/semantics/article Palavras-chave: Acyclovir/skin penetration/in vitro studies; Acyclovir/semisolid formulations; Acyclovir/pharmaceutical equivalence.. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300483 LC-UV method to assay raloxifene hydrochloride in rat plasma and its application to a pharmacokinetic study BJPS Fontana,Márcia Camponogara; Laureano,João Víctor; Forgearini,Betielli; Chaves,Paula dos Santos; Araujo,Bibiana Verlindo de; Beck,Ruy Carlos Ruver. A specific, precise, and accurate LC-UV method was developed and validated to assay raloxifene hydrochloride in rat plasma. Raloxifene was analyzed after liquid-liquid extraction and quantified by reversed phase liquid chromatography (C18 column) using acetonitrile and ammonium acetate buffer 0.05 M (pH 4.0) as mobile phase at a flow rate of 1 mL.min-1 and UV detection at 287 nm. Retention times of raloxifene and internal standard (dexamethasone) were approximately 11 min and 14 min, respectively. Linearity was checked for a concentration range between 25 ng.mL-1 and 1000 ng.mL-1. Intra- and inter-day precision had relative standard deviation lower than 10% and 15%, respectively. Recovery from plasma was higher than 90%. Accuracy values were 98.21%,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Raloxifene/pharmacokinetic; Liquid chromatography.; Plasma.; Bioavailability.. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100538 Registros recuperados: 2 Primeira ... 1 ... Última

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