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High concentrations of KCl release noradrenaline from noradrenergic neurons in the rat anococcygeus muscle BJMBR
Araujo,C.B.L.; Bendhack,L.M..
The aim of the present study was to investigate the effects of high concentrations of KCl in releasing noradrenaline from sympathetic nerves and its actions on postsynaptic alpha-adrenoceptors. We measured the isotonic contractions induced by KCl in the isolated rat anococcygeus muscle under different experimental conditions. The contractile responses induced by KCl were inhibited by alpha-adrenoceptor antagonists in 2.5 mM Ca2+ solution. Prazosin reduced the maximum effect from 100 to 53.9 ± 10.2% (P<0.05) while the pD2 values were not changed. The contractile responses induced by KCl were abolished by prazosin in Ca2+-free solution (P<0.05). Treatment of the rats with reserpine reduced the maximum effect induced by KCl as compared to the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Noradrenaline; KCl; Anococcygeus muscle; Alpha-Adrenoceptors; Noradrenergic neurons.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100013
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