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| Arnich, Nathalie; Abadie, Eric; Delcourt, Nicolas; Fessard, Valérie; Fremy, Jean-marc; Hort, Vincent; Lagrange, Emmeline; Maignien, Thomas; Molgó, Jordi; Peyrat, Marie-bénédicte; Vernoux, Jean-paul; Mattei, César. |
| Pinnatoxins (PnTXs) are a group of emerging marine biotoxins produced by the benthic dinoflagellate Vulcanodinium rugosum, currently not regulated in Europe or in any other country in the world. In France, PnTXs were detected for the first time in 2011, in mussels from the Ingril lagoon (South of France, Mediterranean coast). Since then, analyses carried out in mussels from this lagoon have shown high concentrations of PnTXs for several months each year. PnTXs have also been detected, to a lesser extent, in mussels from other Mediterranean lagoons and on the Atlantic and Corsican coasts. In the French data, the main analog is PnTX G (low levels of PnTX A are also present in some samples). No cases of PnTXs poisoning in humans have been reported so far in... |
| Tipo: Text |
Palavras-chave: Pinnatoxins; Shellfish; Emerging marine biotoxins; Risk assessment. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00619/73105/72236.pdf |
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| Delcourt, Nicolas; Lagrange, Emmeline; Abadie, Eric; Fessard, Valérie; Frémy, Jean-marc; Vernoux, Jean-paul; Peyrat, Marie-bénédicte; Maignien, Thomas; Arnich, Nathalie; Molgó, Jordi; Mattei, César. |
| Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been reported to date although acute toxicity was induced by PnTxs in rodents. LD50 values have been estimated for the different PnTXs through the oral route. At sublethal doses, all symptoms are reversible, and no neurological sequelae are visible. These symptoms are consistent with impairment of central and peripheral cholinergic network functions. In fact, PnTXs are high-affinity competitive antagonists of nicotinic acetylcholine receptors (nAChRs).... |
| Tipo: Text |
Palavras-chave: Pinnatoxins; Cyclic imines; Vulcanodinium rugosum; Nicotinic acetylcholine receptors; Acute neurotoxicity; Human intoxication; Myasthenia gravis. |
| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00507/61883/65958.pdf |
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| Thebault, Anne; Arnich, Nathalie; Belin, Catherine; Neaud-masson, Nadine. |
| In France, the sampling strategy for the official monitoring of lipophilic phycotoxins in bivalve shellfish relies on the definition of risk areas and high risk periods, during which a systematic weekly analysis of toxins in shellfish is performed. Since 2010, high risk periods are defined as follows: the occurrence of one result above the European regulatory limit (160 μg equivalent okadaic acid/kg shellfish) over the last 3 years leads to that month being considered a high risk period. This definition was established according to a statistical analysis of the official monitoring results for the period 2003-2008, based on the mouse bioassay (MBA) as the official analytical method. As of the 1st January 2010, the MBA has been replaced by LC-MS/MS. In 2014,... |
| Tipo: Text |
Palavras-chave: Monitoring; Shellfish; Lipophilic phycotoxins; Bayesian inference. |
| Ano: 2014 |
URL: http://archimer.ifremer.fr/doc/00393/50470/51205.pdf |
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| Gueguen, Marielle; Amiard, Jean-claude; Arnich, Nathalie; Badot, Pierre-marie; Claisse, Didier; Guerin, Thierry; Vernoux, Jean-paul. |
| Shellfish farming is a common industry along European coasts. According to the 2005–2006 data from the French National Shellfish Farming Committee (CNC – Comité National de la Conchyliculture 2010; see Table 1 for a list of acronyms and abbreviations used in this chapter), Spain is the largest shellfish producer in Europe (∼270,000 t) and France ranks second, producing 200,000 t of shellfish annually. France is the leading European oyster producer, with an annual output of 130,000 t of Crassostrea gigas, and ranks fourth in the world after China, Japan, and Korea. The top three European mussel (Mytilus edulis and Mytilus galloprovincialis) producers are Spain (260,000 t), Denmark (80,000 t), and France (65,000 t). For other shellfish, the French annual... |
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| Ano: 2011 |
URL: http://archimer.ifremer.fr/doc/00039/14995/12622.pdf |
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