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Anticancer efficacy of phenolics based structurally related compounds and their radical scavenging action Nature Precedings
Vijaya Dubey; Nusrat Masood; Suaib Luqman; Arvind S. Negi.
Cancer, one of the leading causes of death worldwide, is an abnormal cell proliferation that fails to respond to the normal signals. In an effort to eradicate the growing menace of cancer, a clear understanding of fundamental biology and molecular mechanism of carcinogenesis is essential for targeted therapies. Among the devised strategies in use for cancer treatment, the one that is of immense interest is the development of plant based novel anticancer agents. Due to their tremendous availability, biological activity and efficacy, the phytochemicals deemed a gibbous future in chemoprevention. In the present study, several phenolics based structurally related compounds of steroidal and non-steroidal skeleton were synthesized and tested for their...
Tipo: Poster Palavras-chave: Cancer; Chemistry; Pharmacology.
Ano: 2011 URL: http://precedings.nature.com/documents/6644/version/1
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Biotransformation of artemisinin mediated through fungal strains for obtaining derivatives with novel activities Nature Precedings
Suchita Srivastava; Suaib Luqman; Atiya Fatima; Mahendra P. Darokar; Arvind S. Negi; J K. Kumar; Karuna Shanker; Chandan S. Chanotiya; Sudeep Tandon; Suman P. S. Khanuja.
Artemisinin, a sesquiterpene lactone, is the active antimalarial constituent of Artemisia annua. Several fungal strains Saccharomyces cerevisiae, Aspergillus flavus, Aspergillus niger and Picchia pastoris were used to biotransform artemisinin. Among these strains, A. flavus was the only microorganism capable of transforming artemisinin to deoxyartemisinin in higher yields than the previous reports. The structure of deoxyartemisinin was elucidated by spectroscopy. Deoxyartemisinin showed antibacterial activity against Staphylococcus aureus, S. epidermidis and S. mutans at a minimum inhibitory concentration (MIC) of 1 mg/mL compared to artemisinin whose MIC was >2 mg/mL.
Tipo: Poster Palavras-chave: Biotechnology; Chemistry; Microbiology; Molecular Cell Biology; Pharmacology.
Ano: 2012 URL: http://precedings.nature.com/documents/6925/version/1
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