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	Provedor de dados BJMBR (2) Autor Aschner,M. (2) Arantes,L.P. (1) Farina,M. (1) Machado,M.L. (1) Ribeiro,E.E. (1) Rocha,J.B.T. (1) Soares,F.A.A. (1) Souza,D.O. (1) Syversen,T. (1) Zamberlan,D.C. (1) da Cruz,I.B.M. (1) da Silva,T.C. (1) da Silveira,T.L. (1) Mais... Palavra-chave Aging (1) Antioxidant (1) Astrocytes (1) Glutamate and selenocompounds (1) Guarana (1) Lifespan (1) Methylmercury neurotoxicity (1) Natural products (1) Oxidative stress (1) Reactive oxygen species (1) Xanthines (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Mechanisms involved in anti-aging effects of guarana (Paullinia cupana) in Caenorhabditis elegans BJMBR Arantes,L.P.; Machado,M.L.; Zamberlan,D.C.; da Silveira,T.L.; da Silva,T.C.; da Cruz,I.B.M.; Ribeiro,E.E.; Aschner,M.; Soares,F.A.A.. Guarana (Paullinia cupana) is habitually ingested by people in the Amazon region and is a key ingredient in various energy drinks consumed worldwide. Extension in longevity and low prevalence of chronic age-related diseases have been associated to habitual intake of guarana. Anti-aging potential of guarana was also demonstrated in Caenorhabditis elegans; however, the mechanisms involved in its effects are not clear. Herein, we investigated the putative pathways that regulate the effects of guarana ethanolic extract (GEE) on lifespan using C. elegans. The major known longevity pathways were analyzed through mutant worms and RT-qPCR assay (DAF-2, DAF-16, SKN-1, SIR-2.1, HSF-1). The possible involvement of purinergic signaling was also investigated. This... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Antioxidant; Guarana; Lifespan; Natural products; Xanthines. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000900602 Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity BJMBR Aschner,M.; Syversen,T.; Souza,D.O.; Rocha,J.B.T.; Farina,M.. This review addresses the mechanisms of methylmercury (MeHg)-induced neurotoxicity, specifically examining the role of oxidative stress in mediating neuronal damage. A number of critical findings point to a central role for astrocytes in mediating MeHg-induced neurotoxicity as evidenced by the following observations: a) MeHg preferentially accumulates in astrocytes; b) MeHg specifically inhibits glutamate uptake in astrocytes; c) neuronal dysfunction is secondary to disturbances in astrocytes. The generation of reactive oxygen species (ROS) by MeHg has been observed in various experimental paradigms. For example, MeHg enhances ROS formation both in vivo (rodent cerebellum) and in vitro (isolated rat brain synaptosomes), as well as in neuronal and mixed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Methylmercury neurotoxicity; Oxidative stress; Glutamate and selenocompounds; Reactive oxygen species; Astrocytes. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300001 Registros recuperados: 2 Primeira ... 1 ... Última

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