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| Bonfanti,Gabriela; Bitencourt,Paula Eliete Rodrigues; Bona,Karine Santos De; Peroza,Luis Ricardo; Cargnelutti,Lariane Oliveira; Borges,Raphaela Maleski; Pigatto,Aline Grohe Schirmer; Fachinetto,Roselei; Boligon,Aline Augusti; Athayde,Margareth Linde; Gonçalves,Thissiane de Lima; Moretto,Maria Beatriz. |
| ABSTRACT Solanum guaraniticum is a medicinal plant traditionally used to treat gastric and liver diseases. However, there is no documented evidence corroborating its safety. The present study evaluated the potential toxicity of S. guaraniticum leaf extract after acute administration in rats. Single doses of the extract (1.250, 2.500, and 5.000 mg/kg) were administered by gavage, and the rats were then monitored for 48 h and/or 14 days. Mortality, acute signs of toxicity, and general activity in the open field test were assessed as well as hematological and biochemical parameters, enzymatic activity (δ-aminolevulinate dehydratase and acetylcholinesterase), and oxidative stress parameters (lipid peroxidation level, non-protein thiol content, tissue catalase... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Solanum guaraniticum/leaf extract/toxicity; Solanum guaraniticum/phytochemistry; Medicinal plants; Solanaceae. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000100006 |
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| Kuhn,Andrielle Wouters; Tedesco,Marília; Boligon,Aline Augusti; Frescura,Viviane Dal-Souto; Athayde,Margareth Linde; Tedesco,Solange Bosio. |
| Peltodon longipes is used as a stimulant and emmenagogue. The objective of this study was to perform genotoxic and chromatographic analyses of the extracts of two samples of P. longipes, collected from the cities of Santa Maria and Tupanciretã, RS, Brazil. The Allium cepa assay was used to analyze genotoxicity while high-performance liquid chromatography was employed to determine phenolic compounds. The genotoxicity experiment consisted of nine groups each comprising four A. cepa bulbs. Bulb roots were developed in distilled water and then transferred for the treatments, for 24 hours, and the negative control remained in water. The treatments were: aqueous extracts at concentrations of 5 and 15 g L-1 for each sample, plus four groups treated with 1%... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: P. longipes/antiproliferative effect; P. longipes/genotoxic potential; P. longipes/chromatographic analyses; Allium cepa test/genotoxicity. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300533 |
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| Kuhn,Andrielle Wouters; Tedesco,Marília; Boligon,Aline Augusti; Athayde,Margareth Linde; Laughinghouse IV,Haywood Dail; Tedesco,Solange Bosio. |
| Punica granatum L., locally known as romanzeira, is native to Asia but found throughout Brazil. P. granatum is used for treating inflammatory, infectious and respiratory diseases. The aim of this study was to evaluate the chromatography and genotoxicity of an aqueous extract of P. granatum (pomegranate) fruit peel using the Allium cepa L. test. The experiment set-up entailed 7 treatments: T1-distilled water, T2-tea 5 g.L-1, T3-tea 10 g.L-1, T4-glyphosate at 9.6%, T5-glyphosate with subsequent recovery in distilled water, T6-glyphosate with subsequent recovery in tea 5 g.L-1 and T7-glyphosate with subsequent recovery in tea 10 g.L-1. The rootlets were collected and fixed in ethanol:acetic acid (3:1) for 24 hours, then stored in 70% ethanol under... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Punica granatum L./phytochemistry; Punica granatum L./genotoxicity Punica granatum L./chromatography analysis; Medicinal plants; Pomegranate. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100241 |
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| Güez,Camila Martins; Souza,Raul Oliveira de; Fischer,Paula; Leão,Maria Fernanda de Moura; Duarte,Jonathaline Apollo; Boligon,Aline Augusti; Athayde,Margareth Linde; Zuravski,Luísa; Oliveira,Luís Flávio Souza de; Machado,Michel Mansur. |
| ABSTRACT Ocimum is one of the most important genera of the Lamiaceae family. Several studies about basil and its popular use reveal many characteristics of the herb, including its use as antioxidant, anti-aging, anti-inflammatory, anti-carcinogenic, anti-microbial, and cardiovascular agents, among others. In this paper, we evaluated genotoxic, oxidative, and anti-inflammatory parameters from the extract of Ocimum basilicum in different concentrations, using human leukocytes cultures exposed to challenging agents. Our results confirm that the O. basilicum extract acts as an antioxidant and effectively reverts or subjugates the effects of high oxidizing agents such as hydrogen peroxide. These actions are attributed to its composition, which is rich in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ocimum basilicum/evaluation; Ocimum basilicum/genotoxic effects; Ocimum basilicum/anti-inflammatory properties; Medicinal plants/study.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100606 |
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| Deuschle,Viviane Cecília Kessler Nunes; Deuschle,Regis Augusto Norbert; Bortoluzzi,Mariana Rocha; Athayde,Margareth Linde. |
| Calendula is used widely in cosmetic formulations that present phenolic compounds in their chemical constitution. The objective of our research was to develop and evaluate the stability of topical formulations containing 5% hydro-ethanolic extract of calendula leaves, including spreadability, and in vitro photo-protective, and antioxidant capacity. To evaluate the stability, we used organoleptic characteristics, pH, and viscosity parameters. Antioxidant capacity was measured by the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, and the photo-protective capacity by SPF spectrophotometric measure. All formulations were stable. The calendula extract formulations in gel and cream showed no significant variations in pH, and the cream formulations presented lower... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Calendula officinalis L./pharmacognosy; Topical formulations/in vitro evaluation; Calendula/topical formulations/in vitro evaluation. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100063 |
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