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	Provedor de dados BJPS (2) Autor Baena,Yolima (2) Aragon,Marcela (1) Costa,Geison Modesti (1) Cárdenas,Paola Andrea (1) Hernández,Aura (1) Jimenez-Kairuz,Álvaro (1) Kratz,Jadel Müller (1) Montaña,Jorge Andrés (1) Ospina,Luis Fernando (1) Perez,León Darío (1) Simões,Cláudia Maria Oliveira (1) Mais... Palavra-chave 6-Methylcoumarin/Pharmacokinetics/rats (1) 6-Methylcoumarin/distribution (1) Controlled release (1) Dexibuprofen (1) Hydrophillic matrix. (1) Interpolyelectrolyte complex (1) Intestinal permeability/study (1) Intestinal permeability/study/In vitro (1) Pharmacotechnical properties (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2017 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties BJPS Montaña,Jorge Andrés; Perez,León Darío; Baena,Yolima. ABSTRACT Interpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the self-assembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte complex (SIPEC) composed of Eudragit E® and Eudragit® L100 was obtained at pH 6.0 and characterized and evaluated as a hydrophilic matrix for dexibuprofen. The formation of a SIPEC was monitored by ζ-potential measurements and characterized using infrared spectroscopy, thermal analysis, and scanning electron microscopy. The results indicated that a SIPEC obtained under these conditions can be used as a matrix for controlling the release of dexibuprofen and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Interpolyelectrolyte complex; Pharmacotechnical properties; Dexibuprofen; Controlled release; Hydrophillic matrix.. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200620 In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats BJPS Cárdenas,Paola Andrea; Kratz,Jadel Müller; Hernández,Aura; Costa,Geison Modesti; Ospina,Luis Fernando; Baena,Yolima; Simões,Cláudia Maria Oliveira; Jimenez-Kairuz,Álvaro; Aragon,Marcela. ABSTRACT 6-Methylcoumarin (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity. In order to continue the pre-clinical characterization of this molecule, in vitro intestinal permeability, plasma profile and tissue distribution after oral administration in rats were studied. The permeability of 6MC was evaluated by the Caco-2 cellular model in both the apical-basal (A-B) and basal-apical (B-A) directions. The pharmacokinetics and biodistribution were evaluated in rats after oral and intraperitoneal administration at doses of 200 mg/kg. Transport experiments with Caco-2 cells showed that 6MC presented high permeability at all concentrations evaluated. This finding suggested that 6MC could be transported across the... Tipo: Info:eu-repo/semantics/article Palavras-chave: 6-Methylcoumarin/Pharmacokinetics/rats; 6-Methylcoumarin/distribution; Intestinal permeability/study; Intestinal permeability/study/In vitro. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100621 Registros recuperados: 2 Primeira ... 1 ... Última

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