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	Provedor de dados BJMBR (3) Autor Baracat,E.C. (3) Almeida,C.P. (1) Freitas,F.R. (1) Guerreiro da Silva,I.D.C. (1) Haidar,M.A. (1) Hegg,R. (1) Maranhão,R.C. (1) Massad-Costa,A.M. (1) Nogueira-de-Souza,N.C. (1) Pires,L.A. (1) Prata Lima,M.F. (1) Pulchinelli,A. (1) Simões,M.J. (1) Tavares,E.R. (1) de Carvalho,C.V. (1) Mais... Palavra-chave Anovulation (1) Breast cancer (1) Chemotherapy (1) Drug delivery (1) Estrogen receptor-alpha (1) High-density lipoprotein cholesterol levels (1) Hormone replacement therapy (1) LDL receptor (1) LRP-1 receptor (1) Lipoproteins (1) Melatonin (1) Nanoemulsion (1) Pineal body (1) Polycystic ovary syndrome (1) Polymorphism (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2012 (1) 2009 (1) 2004 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer BJMBR Pires,L.A.; Hegg,R.; Freitas,F.R.; Tavares,E.R.; Almeida,C.P.; Baracat,E.C.; Maranhão,R.C.. Low-density lipoprotein (LDL) receptors are overexpressed in most neoplastic cell lines and provide a mechanism for the internalization and concentration of drug-laden nanoemulsions that bind to these receptors. The aim of the present study was to determine whether the administration of standard chemotherapeutic schemes can alter the expression of LDL and LDL receptor-related protein 1 (LRP-1) receptors in breast carcinoma. Fragments of tumoral and normal breast tissue from 16 consecutive volunteer women with breast cancer in stage II or III were obtained from biopsies before the beginning of neoadjuvant chemotherapy and after chemotherapy, from fragments excised during mastectomy. Tissues were analyzed by immunohistochemistry for both receptors. Because... Tipo: Info:eu-repo/semantics/article Palavras-chave: Breast cancer; Lipoproteins; LDL receptor; LRP-1 receptor; Chemotherapy; Nanoemulsion; Drug delivery. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600012 Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy BJMBR Nogueira-de-Souza,N.C.; Guerreiro da Silva,I.D.C.; de Carvalho,C.V.; Pulchinelli,A.; Haidar,M.A.; Baracat,E.C.; Massad-Costa,A.M.. Studies have shown that estrogen replacement therapy and estrogen plus progestin replacement therapy alter serum levels of total, LDL and HDL cholesterol levels. However, HDL cholesterol levels in women vary considerably in response to hormone replacement therapy (HRT). A significant portion of the variability of these levels has been attributed to genetic factors. Therefore, we investigated the influence of estrogen receptor-alpha (ESR1) gene polymorphisms on HDL levels in response to postmenopausal HRT. We performed a prospective cohort study on 54 postmenopausal women who had not used HRT before the study and had no significant general medical illness. HRT consisted of conjugated equine estrogen and medroxyprogesterone acetate continuously for 1 year.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hormone replacement therapy; High-density lipoprotein cholesterol levels; Estrogen receptor-alpha; Polymorphism. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200003 Effects of melatonin on the ovarian response to pinealectomy or continuous light in female rats: similarity with polycystic ovary syndrome BJMBR Prata Lima,M.F.; Baracat,E.C.; Simões,M.J.. The current study was conducted to investigate the relationship between melatonin and chronic anovulation. Adult (3-4 months old) female Wistar rats were submitted to pinealectomy: group I: pinealectomized ovariectomized melatonin-treated (N = 10); group II: pinealectomized ovariectomized placebo-treated (N = 12); group III: pinealectomized light-treated placebo-treated(N = 10) or maintained under continuous light; group IV: maintained under continuous light, ovariectomized melatonin-treated (N = 22); group V: maintained under continuous light, ovariectomized placebo-treated (N = 10); group VI: maintained under continuous light placebo-treated (N = 10). In order to assess ovarian modifications, unilateral ovariectomy was performed during the fourth month... Tipo: Info:eu-repo/semantics/article Palavras-chave: Melatonin; Polycystic ovary syndrome; Pineal body; Anovulation. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000700007 Registros recuperados: 3 Primeira ... 1 ... Última

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