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| Santos,L.; Davel,A.P.; Almeida,T.I.R.; Almeida,M.R.; Soares,E.A.; Fernandes,G.J.M.; Magalhães,S.F.; Barauna,V.G.; Garcia,J.A.D.. |
| Functional food intake has been highlighted as a strategy for the prevention of cardiovascular diseases by reducing risk factors. In this study, we compared the effects of oral treatment with soy milk and simvastatin on dyslipidemia, left ventricle remodeling and atherosclerotic lesion of LDL receptor knockout mice (LDLr-/-) fed a hyperlipidic diet. Forty 3-month old male LDLr-/- mice were distributed into four groups: control group (C), in which animals received standard diet; HL group, in which animals were fed a hyperlipidic diet; HL+SM or HL+S groups, in which animals were submitted to a hyperlipidic diet plus soy milk or simvastatin, respectively. After 60 days, both soy milk and simvastatin treatment prevented dyslipidemia, atherosclerotic lesion... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Soy milk Dyslipidemia Oxidative stress Inflammation Atherosclerosis; Simvastatin. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000300701 |
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| Barretti,D.L.M.; Melo,S.F.S.; Oliveira,E.M.; Barauna,V.G.. |
| Elevated salt intake induces changes in the extracellular matrix collagen, leading to myocardial stiffness and impaired relaxation. Resistance training (RT) has been used as a remarkably successful strategy in the treatment of heart disease. Therefore, the aim of this study was to investigate the effects of RT on preventing pathological adaptation of the left ventricle (LV) induced by salt overload. Male Wistar rats (10 weeks old) were distributed into four groups (n=8/group): control (CO), control+1% salt (CO+SALT), RT and RT+1% salt (RT+SALT). The RT protocol consisted of 4×12 bouts of squat training, 5/week for 8 weeks, with 80% of one repetition maximum (1RM). Echocardiographs were analyzed and interstitial collagen volume fraction (CVF) was determined... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diastolic dysfunction; Interstitial collagen; Resistance training; Salt overload. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000900603 |
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