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Decorin is one of the proteoglycans expressed in Walker 256 rat mammary carcinoma BJMBR
Oba-Shinjo,S.M.; Berto,A.G.A.; Passerotti,C.C.; Barbosa,C.D.; Sampaio,L.O..
Proteoglycan and glycosaminoglycan content was analyzed in a model of rat mammary carcinoma to study the roles of these compounds in tumorigenesis. Hyaluronic acid and proteoglycans bearing chondroitin and/or dermatan sulfate chains were detected in solid tumors obtained after subcutaneous inoculation of Walker 256 rat carcinoma cells. About 10% of sulfated glycosaminoglycan chains corresponded to heparan sulfate. The small leucine-rich proteoglycan, decorin, was identified as one of the proteoglycans, in addition to others of higher molecular weight, by cross-reaction with an antiserum raised against pig laryngeal decorin and by N-terminal amino acid sequencing. Decorin was separated from other proteoglycans by hydrophobic chromatography and its complete...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Proteoglycan; Glycosaminoglycan; Walker 256 tumor; Carcinoma.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800015
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