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	Provedor de dados Genet. Mol. Biol. (2) BJID (1) Autor Barreto,José Henrique (3) Barbosa,Cynara Gomes (2) Moura Neto,José Pereira de (2) Reis,Mitermayer Galvão (2) Souza,Claudio Lima (2) Arruda,Maria da Glória Bomfim (1) Goncalves,Marilda Souza (1) Gonçalves,Marilda Souza (1) Mais... Palavra-chave AML (1) Acute promyelocytic leukemia (1) CML (1) Chronic myeloid leukemia (1) GSTM1 (1) GSTT1 (1) Gene polymorphism (1) MTHFR polymorphisms (1) Mais... Tipo do documento Info:eu-repo/semantics/other (2) Info:eu-repo/semantics/report (1) Ano 2008 (2) 2005 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Burkitt Non-Hodgkin Lymphoma in childhood BJID Barreto,José Henrique. Tipo: Info:eu-repo/semantics/report Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500029 Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients Genet. Mol. Biol. Souza,Claudio Lima; Barbosa,Cynara Gomes; Moura Neto,José Pereira de; Barreto,José Henrique; Reis,Mitermayer Galvão; Gonçalves,Marilda Souza. The null genotype for glutathione S-transferase (GST, EC 2.5.1.18) gene polymorphisms is considered a risk factor for leukemia in different populations. In this work we investigated the GSTT1 and GSTM1 polymorphisms using multiplex PCR in 53 patients with chronic myeloid leukemia (CML), 23 with acute promyelocytic leukemia (APL) and 304 apparently healthy controls. In this association study we found that the GSTT1null genotype was more frequent in our group of APL patients than in the control group [OR = 2.75 (95% CI = 1.10-6.88)], providing evidence that a deletion in the GSTT1 gene could be a risk factor for this type of leukemia. Tipo: Info:eu-repo/semantics/other Palavras-chave: Acute promyelocytic leukemia; Chronic myeloid leukemia; GSTM1; GSTT1; Gene polymorphism. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000100008 Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil Genet. Mol. Biol. Barbosa,Cynara Gomes; Souza,Claudio Lima; Moura Neto,José Pereira de; Arruda,Maria da Glória Bomfim; Barreto,José Henrique; Reis,Mitermayer Galvão; Goncalves,Marilda Souza. Methylenetetrahydrofolate reductase (MTHFR: EC 1.5.1.20) polymorphisms are associated to acute lymphoid leukemia in different populations. We used the polymerase chain reaction and the restriction fragment length polymorphism method (PCR-RFLP) to investigate MTHFR C677T and A1298C polymorphism frequencies in 67 patients with chronic myeloid leukemia (CML), 27 with acute myeloid leukemia FAB subtype M3 (AML-M3) and 100 apparently healthy controls. The MTHFR mutant allele frequencies were as follows: CML = 17.2% for C677T, 21.6% for A1298C; AML-M3 = 22.2% for C677T, 24.1% for A1298C; and controls = 20.5% for C677T, 21% for A1298C. Taken together, our results provide evidence that MTHFR polymorphisms have no influence on the development of CML or AML-M3. Tipo: Info:eu-repo/semantics/other Palavras-chave: AML; CML; MTHFR polymorphisms. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000100005 Registros recuperados: 3 Primeira ... 1 ... Última

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