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	Provedor de dados BJMBR (2) Autor Barreto-Chaves,M.L.M. (2) Brum,P.C. (1) Cunha,T.F. (1) Fortunato,R.S. (1) Gabriel-Costa,D. (1) Heimann,A. (1) Krieger,J.E. (1) Paixão,N.A. (1) Rego-Monteiro,I.C.C. (1) Mais... Palavra-chave Angiotensin-converting enzyme (1) Cardiac myocytes (1) Dexamethasone (1) Gene expression (1) Lactate (1) Lactate oxidation complex (1) Myocardial infarction (1) Oxidative stress (1) Perfusion pressure (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Lactate-upregulation of lactate oxidation complex-related genes is blunted in left ventricle of myocardial infarcted rats BJMBR Gabriel-Costa,D.; Cunha,T.F.; Paixão,N.A.; Fortunato,R.S.; Rego-Monteiro,I.C.C.; Barreto-Chaves,M.L.M.; Brum,P.C.. Lactate modulates the expression of lactate oxidation complex (LOC)-related genes and cardiac blood flow under physiological conditions, but its modulatory role remains to be elucidated regarding pathological cardiac stress. The present study evaluated the effect of lactate on LOC-related genes expression and hemodynamics of hearts submitted to myocardial infarction (MI). Four weeks after MI or sham operation, isolated hearts of male Wistar rats were perfused for 60 min with Na+-lactate (20 mM). As expected, MI reduced cardiac contractility and relaxation with no changes in perfusion. The impaired cardiac hemodynamics were associated with increased reactive oxygen species (ROS) levels (Sham: 19.3±0.5 vs MI: 23.8±0.3 µM), NADPH oxidase (NOX) activity (Sham:... Tipo: Info:eu-repo/semantics/article Palavras-chave: Lactate; Lactate oxidation complex; Myocardial infarction; Gene expression; Perfusion pressure; Oxidative stress. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001100605 Stimulatory effect of dexamethasone on angiotensin-converting enzyme in neonatal rat cardiac myocytes BJMBR Barreto-Chaves,M.L.M.; Heimann,A.; Krieger,J.E.. Angiotensin-converting enzyme (ACE) plays a central role in cardiac remodeling associated with pathological conditions such as myocardial infarction. The existence of different cell types in the heart expressing components of the renin-angiotensin system makes it difficult to evaluate their relative role under physiological and pathological conditions. Since myocytes are the predominant cellular constituent of the heart by mass, in the present study we studied the effects of glucocorticoids on ACE activity using well-defined cultures of neonatal rat cardiac myocytes. Under steady-state conditions, ACE activity was present at very low levels, but after dexamethasone treatment ACE activity increased significantly (100 nmol/l after 24 h) in a time-dependent... Tipo: Info:eu-repo/semantics/article Palavras-chave: Dexamethasone; Cardiac myocytes; Angiotensin-converting enzyme. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600007 Registros recuperados: 2 Primeira ... 1 ... Última

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