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| Souza,M.; Moraes,S.A.S.; de Paula,D.R.; Maciel,A.A.; Batista,E.J.O.; Silva,D.G.F.; Bahia,C.P.; Oliveira,K.R.H.M.; Herculano,A.M.. |
| Tendon rupture is a very frequent accident involving average people and high-performance athletes. Clinical studies describe tendon recovery as a painful and slow process involving different biochemical and histological events. Ascorbic acid (AA) is a potent antioxidant as well as an important cofactor for collagen synthesis. In the current study, we evaluated if local treatment with AA is able to promote tendon repair in tenotomized rats. Animals were submitted to Achilles tendon rupture followed by surgical suture. Control and AA groups received in loco injection of saline solution (0.9% NaCl) and 30 mM AA, respectively. Histological and functional recovery of Achilles tendon tissue was evaluated at 7, 14, and 21 days post-surgery. Hematoxylin/eosin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tendon recovery; Tenotomy; Ascorbic acid; Tendon suture. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000900608 |
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| Seabra,A.D.; Moraes,S.A.S.; Batista,E.J.O.; Garcia,T.B.; Souza,M.C.; Oliveira,K.R.M.; Herculano,A.M.. |
| Muscular atrophy is a progressive degeneration characterized by muscular proteolysis, loss of mass and decrease in fiber area. Tendon rupture induces muscular atrophy due to an intrinsic functional connection. Local inhibition of nitric oxide synthase (NOS) by Nω-nitro-L-arginine methyl ester (L-NAME) accelerates tendon histological recovery and induces functional improvement. Here we evaluate the effects of such local nitrergic inhibition on the pattern of soleus muscle regeneration after tenotomy. Adult male Wistar rats (240 to 280 g) were divided into four experimental groups: control (n=4), tenotomized (n=6), vehicle (n=6), and L-NAME (n=6). Muscular atrophy was induced by calcaneal tendon rupture in rats. Changes in muscle wet weight and total protein... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nitric oxide; Muscle regeneration; Atrophy; Tendon; Tenotomy. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000300601 |
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