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	Provedor de dados Genet. Mol. Biol. (2) Autor Benjeddou,Mongi (2) Du Plessis,Mornè (1) Geduld-Ullah,Tasneem (1) Hoosain,Nisreen (1) Isaacs,Shafieka (1) Jacobs,Clifford (1) Pearce,Brendon (1) Mais... Palavra-chave Population genetic structure (2) Chromosome variations (1) Genetic polymorphism (1) Genetic variability (1) Genotyping (1) Haplotype (1) Mitochondrial DNA (1) PCR-RFLP (1) Polymorphism (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 2013 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Genetic polymorphisms and haplotypes of the organic cation transporter 1 gene (SLC22A1) in the Xhosa population of South Africa Genet. Mol. Biol. Jacobs,Clifford; Pearce,Brendon; Du Plessis,Mornè; Hoosain,Nisreen; Benjeddou,Mongi. Human organic cation transporter 1 is primarily expressed in hepatocytes and mediates the electrogenic transport of various endogenous and exogenous compounds, including clinically important drugs. Genetic polymorphisms in the gene coding for human organic cation transporter 1, SLC22A1, are increasingly being recognized as a possible mechanism explaining the variable response to clinical drugs, which are substrates for this transporter. The genotypic and allelic distributions of 19 nonsynonymous and one intronic SLC22A1 single nucleotide polymorphisms were determined in 148 healthy Xhosa participants from South Africa, using a SNAPshot® multiplex assay. In addition, haplotype structure for SLC22A1 was inferred from the genotypic data. The minor allele... Tipo: Info:eu-repo/semantics/article Palavras-chave: Polymorphism; Haplotype; Population genetic structure; Genotyping; Genetic variability. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000300006 Reconstruction of major maternal and paternal lineages of the Cape Muslim population Genet. Mol. Biol. Isaacs,Shafieka; Geduld-Ullah,Tasneem; Benjeddou,Mongi. The earliest Cape Muslims were brought to the Cape (Cape Town -South Africa) from Africa and Asia from 1652 to 1834. They were part of an involuntary migration of slaves, political prisoners and convicts, and they contributed to the ethnic diversity of the present Cape Muslim population of South Africa. The history of the Cape Muslims has been well documented and researched however no in-depth genetic studies have been undertaken. The aim of the present study was to determine the respective African, Asian and European contributions to the mtDNA (maternal) and Y-chromosomal (paternal) gene pool of the Cape Muslim population, by analyzing DNA samples of 100 unrelated Muslim males born in the Cape Metropolitan area. A panel of six mtDNA and eight Y-chromosome... Tipo: Info:eu-repo/semantics/article Palavras-chave: PCR-RFLP; Genetic polymorphism; Mitochondrial DNA; Population genetic structure; Chromosome variations. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000200005 Registros recuperados: 2 Primeira ... 1 ... Última

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