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| Brunoni,A.R.; Santos,I.S.; Sabbag,C.; Lotufo,P.A.; Benseñor,I.M.. |
| Psoriasis is a chronic inflammatory disease that significantly impacts life quality, being associated with stress and mental disorders. We investigated whether the activity of the hypothalamic-pituitary-adrenal (HPA) axis was associated with psoriasis severity, daily life stress and anxiety, and depressive symptoms. In this ancillary study, which was part of the CALIPSO (coronary artery calcium in psoriasis) study, saliva was collected from 102 patients with psoriasis immediately upon awakening, 30, and 60 min after awakening, at 2:00 pm and at bedtime (five time points) to determine salivary cortisol levels. We used Pearson's correlation coefficient to evaluate the association of clinical and psychopathological variables with HPA activity. We found a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Psoriasis; Cortisol; HPA function; Clinical study. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201102 |
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| de Miranda,E.J.F. Peixoto; Bittencourt,M.S.; Staniak,H.L.; Sharovsky,R.; Pereira,A.C.; Foppa,M.; Santos,I.S.; Lotufo,P.A.; Benseñor,I.M.. |
| Data on the association between subclinical thyroid dysfunction and coronary artery disease (CAD) is scarce. We aimed to analyze the association between thyroid function and CAD using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We included subjects with normal thyroid function (0.4-4.0 mIU/L, and normal free thyroxine, FT4, or 0.8 to 1.9 ng/dL), subclinical hypothyroidism (SCHypo; TSH>4.0 mIU/L and normal FT4), and subclinical hyperthyroidism (SCHyper; TSH<0.4 mIU/L and normal FT4) evaluated by coronary computed tomography angiography. We excluded individuals using medications that interfere in thyroid function or with past medical history of cardiovascular disease. Logistic regression models evaluated the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Thyroid disorders; Thyrotropin levels; Coronary artery disease; Coronary computed tomography angiography; Subclinical atherosclerosis; Cardiovascular disease. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000500609 |
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| Brunoni,A.R.; Lotufo,P.A.; Sabbag,C.; Goulart,A.C.; Santos,I.S.; Benseñor,I.M.. |
| Brain-derived neurotrophic factor (BDNF) is associated with neuroplasticity and synaptic strength, and is decreased in conditions associated with chronic stress. Nevertheless, BDNF has not yet been investigated in psoriasis, a chronic inflammatory systemic disease that is exacerbated by stress. Therefore, our aim was to determine BDNF plasma levels in psoriasis patients and healthy controls. Adult patients (n=94) presenting with psoriasis for at least 1 year were enrolled, and age- and gender-matched with healthy controls (n=307) from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Participants had neither a previous history of coronary artery disease nor current episode of major depression. BDNF plasma levels were determined using the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brain derived neurotrophic factor; Psoriasis; Neurotrophins; Psychological stress; Case-control study. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000800711 |
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| de Miranda,É.J.F. Peixoto; Hoshi,R.A.; Bittencourt,M.S.; Goulart,A.C.; Santos,I.S.; Brunoni,A.R.; Diniz,M.F.H.S.; Ribeiro,A.L.P.; Dantas,E.M.; Mill,J.G.; Lotufo,P.A.; Benseñor,I.M.. |
| The association between subclinical thyroid dysfunctions and autonomic modulation changes has been described by many studies with conflicting results. We aimed to analyze the association between subclinical hyperthyroidism (SCHyper), subclinical hypothyroidism (SCHypo), and heart rate variability (HRV) using the baseline from ELSA-Brasil. SCHyper and SCHypo were classified by use of medication to treat thyroid disorders, thyrotropin levels respectively above and under the reference range, and normal free thyroxine levels. For HRV, the participants underwent 10 min in supine position and the R-R intervals of the final 5 min were selected for analysis. We first used linear regression models to report crude data and then, multivariate adjustment for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Subclinical hypothyroidism; Subclinical hyperthyroidism; Heart rate variability; Autonomic nervous system. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001100601 |
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| Valiengo,L.C.L.; Benseñor,I.M.; Lotufo,P.A.; Fraguas Jr,R.; Brunoni,A.R.. |
| Patients with clinical diseases often present psychiatric conditions whose pharmacological treatment is hampered due to hazardous interactions with the clinical treatment and/or disease. This is particularly relevant for major depressive disorder, the most common psychiatric disorder in the general hospital. In this context, nonpharmacological interventions could be useful therapies; and, among those, noninvasive brain stimulation (NIBS) might be an interesting option. The main methods of NIBS are repetitive transcranial magnetic stimulation (rTMS), which was recently approved as a nonresearch treatment for some psychiatric conditions, and transcranial direct current stimulation (tDCS), a technique that is currently limited to research scenarios but has... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Neuromodulation; Liaison; Major depressive disorder; Transcranial stimulation. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001000815 |
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