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| Nascimento,Demétrius Fernandes do; Moraes,Manoel Odorico de; Bezerra,Fernando Antônio Frota; Pontes,Andréa Vieira; Uchoa,Célia Regina Amaral; Moraes,Renata Amaral de; Leite,Ismenia Osório; Santana,Gilmara Silva de Melo; Santana,Ana Paula Macedo; Leite,Ana Lourdes Almeida e Silva; Pedrazzoli Júnior,José; Moraes,Maria Elisabete Amaral de. |
| To develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS). The analyte and IS were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1 v/v). The chromatographic separation was performed on a Varian® Polaris C18 analytical column (3 μm, 50 x 2.0 mm) and pre-column SecurityguardTM C18 (4.0 x 3.0 mm) with a mobile phase of Acetonitrile-Ammonium acetate 0.02 ml/L (80:20v/v). The method had a chromatographic run time of 4.5 min and linear calibration curve over the range of 0.1- 40 ng/mL (r > 0.9938). The limit of quantification was 100 pg/mL. Acceptable precision and accuracy were obtained for concentrations over the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nimodipine/determination in plasma; Nimodipine/pharmacokinetic profile; Nimodipine/quantitative analysis; Pharmacokinetics/method validation. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400008 |
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| Carvalho,Elisete Mendes; Cunha,Gilmara Holanda da; Fechine,Francisco Vagnaldo; Uchôa,Célia Regina Amaral; Moraes Filho,Manoel Odorico de; Bezerra,Fernando Antônio Frota; Moraes,Maria Elisabete Amaral de. |
| Amburana cearensis is a medicinal plant known as "cumaru". It is used in Northeast Brazil in the treatment of respiratory diseases. This was a randomized, double-blind, placebo-controlled study, with the aim of evaluating the efficacy and safety of cumaru syrup as complementary therapy in mild persistent asthma. The study consisted of 3 phases, pre-treatment, treatment and post-treatment. The primary efficacy outcome was comparison of the changes reported by patients of the cumaru and placebo groups after treatment, using the "Asthma Quality of Life Questionnaire" (AQLQ). The secondary outcome was the effect of cumaru syrup on lung function based on spirometry. The results showed that in the cumaru group, the proportion of patients who had global... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amburana cearensis/phytoterapy; Cumaru syrup/efficacy; Asthma/treatment. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400006 |
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