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	Provedor de dados Genet. Mol. Biol. (2) Autor Bizari,Lucimari (2) Silva,Ana Elizabete (2) Tajara,Eloiza H. (1) Tajara,Eloiza Helena (1) Palavra-chave CCND1 (1) Carcinomas (1) Chromosome territories (1) Double minutes (1) Esophageal carcinoma (1) Gastric cancer (1) Gene amplification (1) Gene expression (1) HER-2/neu (1) Oncogenes (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2009 (1) 2006 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Peripheral position of CCND1 and HER-2/neu oncogenes within chromosome territories in esophageal and gastric cancers non-related to amplification and overexpression Genet. Mol. Biol. Bizari,Lucimari; Tajara,Eloiza Helena; Silva,Ana Elizabete. Interphase chromosomes have been shown to occupy discrete regions of the nucleus denominated chromosome territories (CTs), their active genes being preferentially positioned on the surfaces of these CTs, where they are accessible to transcriptional machinery. By means of FISH (Fluorescence in situ Hybridization), we analyzed the CCND1 and HER-2/neu gene positions within the CTs and their relationship with gene amplification and protein over-expression in esophageal and gastric cancers. The CCND1 and HER-2/Neu genes were more often positioned at the periphery (mean frequency of 60%-83%) of the CTs in tumor tissues of the esophagus and stomach. Moreover, this positioning revealed no association with either gene amplification or the protein over-expression... Tipo: Info:eu-repo/semantics/article Palavras-chave: CCND1; HER-2/neu; Chromosome territories; Esophageal carcinoma; Gastric cancer. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200006 Gene amplification in carcinogenesis Genet. Mol. Biol. Bizari,Lucimari; Silva,Ana Elizabete; Tajara,Eloiza H.. Gene amplification increases the number of genes in a genome and can give rise to karyotype abnormalities called double minutes (DM) and homogeneously staining regions (HSR), both of which have been widely observed in human tumors but are also known to play a major role during embryonic development due to the fact that they are responsible for the programmed increase of gene expression. The etiology of gene amplification during carcinogenesis is not yet completely understood but can be considered a result of genetic instability. Gene amplification leads to an increase in protein expression and provides a selective advantage during cell growth. Oncogenes such as CCND1, c-MET, c-MYC, ERBB2, EGFR and MDM2 are amplified in human tumors and can be associated... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gene amplification; Gene expression; Oncogenes; Carcinomas; Double minutes. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000100001 Registros recuperados: 2 Primeira ... 1 ... Última

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