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	Provedor de dados BJMBR (2) Autor Boichot,E. (2) Lagente,V. (2) Corbel,M. (1) Le Quément,C. (1) Manoury,B. (1) Martin-Chouly,C. (1) Nénan,S. (1) Mais... Palavra-chave Matrix metalloproteinase (2) ARDS (1) Acute lung injury (1) Chronic obstructive pulmonary disease (1) Extracellular matrix (1) Fibrosis (1) Inflammation (1) LPS (1) Lung (1) TIMPs (1) Tissue inhibitor of matrix metalloproteinases (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2005 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury BJMBR Corbel,M.; Boichot,E.; Lagente,V.. Acute lung injury is characterized by a severe disruption of alveolo-capillary structures and includes a variety of changes in lung cell populations. Evidence suggests the occurrence of rupture of the basement membranes and interstitial matrix remodeling during acute lung injury. The dynamic equilibrium of the extracellular matrix (ECM) under physiological conditions is a consequence of the balance between the regulation of synthesis and degradation of ECM components. Matrix metalloproteinases (MMPs) represent a group of enzymes involved in the degradation of most of the components of the ECM and therefore participate in tissue remodeling associated with pathological situations such as acute lung injury. MMP activity is regulated by proteolytic activation... Tipo: Info:eu-repo/semantics/article Palavras-chave: Matrix metalloproteinase; TIMPs; Acute lung injury; ARDS; LPS; Extracellular matrix. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700004 Role of matrix metalloproteinases in the development of airway inflammation and remodeling BJMBR Lagente,V.; Manoury,B.; Nénan,S.; Le Quément,C.; Martin-Chouly,C.; Boichot,E.. Matrix metalloproteinases (MMPs) are a major group of proteases known to regulate extracellular matrix (ECM) turnover and so they have been suggested to be important in the process of lung disease associated with tissue remodeling. This has led to the concept that modulation of airway remodeling including excessive proteolysis damage to the tissue may be of interest for future treatment. Within the MMP family, macrophage elastase (MMP-12) is able to degrade ECM components such as elastin and is involved in tissue remodeling processes in chronic obstructive pulmonary disease including emphysema. Pulmonary fibrosis has an aggressive course and is usually fatal within an average of 3 to 6 years after the onset of symptoms. Pulmonary fibrosis is associated... Tipo: Info:eu-repo/semantics/article Palavras-chave: Fibrosis; Inflammation; Lung; Matrix metalloproteinase; Tissue inhibitor of matrix metalloproteinases; Chronic obstructive pulmonary disease. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000009 Registros recuperados: 2 Primeira ... 1 ... Última

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