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| Zanaga,L.P.; Santos,A.G.; Ataíde,E.C.; Boin,I.F.S.F.; Stucchi,R.S.B.. |
| Recurrent hepatitis C (HCV) after liver transplantation (LT) is an important cause of morbidity and mortality. Antiviral treatment is recommended to avoid unfavorable outcomes. Direct-acting antivirals (DAA) have transformed HCV treatment, with higher efficacy and fewer side-effects than interferon-based therapies traditionally used. To evaluate DAA treatment outcomes at a Brazilian transplant unit, data of patients who finished HCV treatment at the Liver Transplant Unit of the University of Campinas were analyzed. Treatment consisted of sofosbuvir, daclatasvir, and ribavirin, for 12 or 24 weeks, according to the national guidelines. Fifty-five patients completed antiviral treatment and 54 had HCV-viral load results available. The majority of patients were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C; Liver transplantation; Direct acting antivirals; Sofosbuvir; Daclatasvir; Recurrent hepatitis. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000800606 |
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| Zanaga,L.P.; Vigani,A.G.; Angerami,R.N.; Giorgetti,A.; Escanhoela,C.A.F.; Ataíde,E.C.; Boin,I.F.S.F.; Stucchi,R.S.B.. |
| Recurrent hepatitis C after orthotopic liver transplantation (OLT) is universal and can lead to graft failure and, consequently, reduced survival. Hepatitis C treatment can be used to prevent these detrimental outcomes. The aim of this study was to describe rates of hepatitis C recurrence and sustained virological response (SVR) to interferon-based treatment after OLT and its relationship to survival and progression of liver disease through retrospective analysis of medical records of 127 patients who underwent OLT due to cirrhosis or hepatocellular carcinoma secondary to chronic hepatitis C between January 2002 and December 2013. Fifty-six patients were diagnosed with recurrent disease, 42 started interferon-based therapy and 37 completed treatment.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C; Liver transplantation; Sustained virological response; Recurrent hepatitis C; Transplantation outcomes. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000100701 |
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