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	Provedor de dados BJMBR (3) Autor Bonato,V.L.D. (3) Silva,C.L. (3) Faccioli,L.H. (1) Fedatto,P.F. (1) Fonseca,D.M. (1) Fonseca,D.M. da (1) Franco,L.H. (1) Gembre,A.F. (1) Lima,V.M.F. (1) Medeiros,A.I. (1) Paula,M. Oliveira e (1) Ramos,S.G. (1) Sartori,A. (1) Sérgio,C.A. (1) Wowk,P.F. (1) Mais... Palavra-chave Tuberculosis (3) Atherosclerosis (1) Cholesterol (1) Cytokines (1) DNA vaccination (1) DNA-HSP65 (1) Genetic vaccine (1) Leukotrienes (1) Prime-boost immunization (1) Th1 (1) Th1/Th2 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Info:eu-repo/semantics/other (1) Ano 2010 (1) 2007 (1) 1999 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última DNA encoding individual mycobacterial antigens protects mice against tuberculosis BJMBR Silva,C.L.; Bonato,V.L.D.; Lima,V.M.F.. Over the last few years, some of our experiments in which mycobacterial antigens were presented to the immune system as if they were viral antigens have had a significant impact on our understanding of protective immunity against tuberculosis. They have also markedly enhanced the prospects for new vaccines. We now know that individual mycobacterial protein antigens can confer protection equal to that from live BCG vaccine in mice. A critical determinant of the outcome of immunization appears to be the degree to which antigen-specific cytotoxic T cells are generated by the immune response. Our most recent studies indicate that DNA vaccination is an effective way to establish long-lasting cytotoxic T cell memory and protection against tuberculosis. Tipo: Info:eu-repo/semantics/article Palavras-chave: Tuberculosis; DNA vaccination; Cytokines; Th1/Th2. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000200012 Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis BJMBR Fonseca,D.M.; Bonato,V.L.D.; Silva,C.L.; Sartori,A.. We previously reported that a DNA vaccine constructed with the heat shock protein (HSP65) gene from Mycobacterium leprae (DNA-HSP65) was protective and also therapeutic in experimental tuberculosis. By the intramuscular route, this vaccine elicited a predominant Th1 response that was consistent with its protective efficacy against tuberculosis. It has been suggested that the immune response to Hsp60/65 may be the link between exposure to microorganisms and increased cardiovascular risk. Additionally, the high cholesterol levels found in atherosclerosis could modulate host immunity. In this context, we evaluated if an atherogenic diet could modulate the immune response induced by the DNA-HSP65 vaccine. C57BL/6 mice (4-6 animals per group) were initially... Tipo: Info:eu-repo/semantics/article Palavras-chave: DNA-HSP65; Genetic vaccine; Atherosclerosis; Tuberculosis; Th1; Cholesterol. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100010 Leukotrienes are not essential for the efficacy of a heterologous vaccine against Mycobacterium tuberculosis infection BJMBR Franco,L.H.; Paula,M. Oliveira e; Wowk,P.F.; Fonseca,D.M. da; Sérgio,C.A.; Fedatto,P.F.; Gembre,A.F.; Ramos,S.G.; Silva,C.L.; Medeiros,A.I.; Faccioli,L.H.; Bonato,V.L.D.. Leukotrienes are reported to be potent proinflammatory mediators that play a role in the development of several inflammatory diseases such as asthma, rheumatoid arthritis and periodontal disease. Leukotrienes have also been associated with protection against infectious diseases. However, the role of leukotrienes in Mycobacterium tuberculosis infection is not understood. To answer this question, we studied the role of leukotrienes in the protective immune response conferred by prime-boost heterologous immunization against tuberculosis. We immunized BALB/c mice (4-11/group) with subcutaneous BCG vaccine (1 x 10(5) M. bovis BCG) (prime) followed by intramuscular DNA-HSP65 vaccine (100 µg) (boost). During the 30 days following the challenge, the animals were... Tipo: Info:eu-repo/semantics/other Palavras-chave: Tuberculosis; Prime-boost immunization; Leukotrienes. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700006 Registros recuperados: 3 Primeira ... 1 ... Última

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