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	Provedor de dados BJMBR (2) Autor Bonfante-Cabarcas,R. (2) Castañeda Perozo,D. (1) Gutiérrez-Guédez,L. (1) Lankford,C.R. (1) Marques,J. (1) Mijares,A. (1) Peraza-Cruces,K. (1) Rodríguez-Angulo,H. (1) Rodríguez-Bonfante,C. (1) Toro-Mendoza,J. (1) Mais... Palavra-chave Arrhythmias (1) Chagas disease (1) Chagas' disease (1) Immunogenic theory (1) Ischemia (1) Muscarinic acetylcholine receptor (1) Neurogenic theory (1) Super-sensitivity (1) Trypanosoma cruzi (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2013 (1) 2008 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Trypanosoma cruzi infection induces up-regulation of cardiac muscarinic acetylcholine receptors in vivo and in vitro BJMBR Peraza-Cruces,K.; Gutiérrez-Guédez,L.; Castañeda Perozo,D.; Lankford,C.R.; Rodríguez-Bonfante,C.; Bonfante-Cabarcas,R.. The pathogenesis of chagasic cardiomyopathy is not completely understood, but it has been correlated with parasympathetic denervation (neurogenic theory) and inflammatory activity (immunogenic theory) that could affect heart muscarinic acetylcholine receptor (mAChR) expression. In order to further understand whether neurogenic and/or immunogenic alterations are related to changes in mAChR expression, we studied two models of Trypanosoma cruzi infection: 1) in 3-week-old male Sprague Dawley rats chronically infected with T. cruzi and 2) isolated primary cardiomyocytes co-cultured with T. cruzi and peripheral blood mononuclear cells (PBMC). Using [³H]-quinuclidinylbenzilate ([³H]-QNB) binding assays, we evaluated mAChR expression in homogenates from selected... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas disease; Muscarinic acetylcholine receptor; Super-sensitivity; Trypanosoma cruzi; Immunogenic theory; Neurogenic theory. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000900009 Induction of chagasic-like arrhythmias in the isolated beating hearts of healthy rats perfused with Trypanosoma cruzi-conditioned medium BJMBR Rodríguez-Angulo,H.; Toro-Mendoza,J.; Marques,J.; Bonfante-Cabarcas,R.; Mijares,A.. Chagas' myocardiopathy, caused by the intracellular protozoan Trypanosoma cruzi, is characterized by microvascular alterations, heart failure and arrhythmias. Ischemia and arrythmogenesis have been attributed to proteins shed by the parasite, although this has not been fully demonstrated. The aim of the present investigation was to study the effect of substances shed by T. cruzi on ischemia/reperfusion-induced arrhythmias. We performed a triple ischemia-reperfusion (I/R) protocol whereby the isolated beating rat hearts were perfused with either Vero-control or Vero T. cruzi-infected conditioned medium during the different stages of ischemia and subsequently reperfused with Tyrode's solution. ECG and heart rate were recorded during the entire experiment. We... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas' disease; Arrhythmias; Ischemia. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000100058 Registros recuperados: 2 Primeira ... 1 ... Última

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