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Strontium ranelate as a possible disease-modifying osteoarthritis drug: a systematic review BJMBR
Rodrigues,T.A.; Freire,A.O.; Bonfim,B.F.; Cartágenes,M.S.S.; Garcia,J.B.S..
Considering that osteoarthritis (OA) is the most prevalent joint disease worldwide, multiple pharmacological treatments have been proposed to alter the articular structure with potential benefit in the progression of the disease. The so-called disease-modifying OA drugs have been frequently investigated but conclusive findings are rare. Strontium ranelate (SrRan) is a drug usually prescribed to treat osteoporosis, with proven effects in decreasing the risk of fractures and possible effect in reducing the progression of OA. The objective of this review was to demonstrate the current panorama of knowledge on the use of SrRan in clinical and experimental models, clarifying its mechanisms of action and describing possible anti-nociceptive and anti-inflammatory...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Osteoarthritis; Strontium ranelate; Treatment; Pain; Symptoms.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000800302
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