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	Provedor de dados BABT (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Andrade Junior,Heitor Franco de (2) Borborema,Samanta Etel Treiger (2) Nascimento,Nanci do (2) Osso Junior,João Alberto (2) Palavra-chave Meglumine antimoniate (2) Antimony (1) Biodistribution (1) Cutaneous leishmaniasis (1) Leishmania (L.) chagasi (1) Leishmaniasis (1) Pharmacokinetics (1) Radioisotope (1) Radiotracer (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2005 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Pharmacokinetics of neutron-irradiated meglumine antimoniate in Leishmania amazonensis-infected BALB/c mice J. Venom. Anim. Toxins incl. Trop. Dis. Borborema,Samanta Etel Treiger; Osso Junior,João Alberto; Andrade Junior,Heitor Franco de; Nascimento,Nanci do. Abstract Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by the protozoan Leishmania spp. Pentavalent antimonial agents have been used as an effective therapy, despite their side effects and resistant cases. Their pharmacokinetics remain largely unexplored. This study aimed to investigate the pharmacokinetic profile of meglumine antimoniate in a murine model of cutaneous leishmaniasis using a radiotracer approach. Methods: Meglumine antimoniate was neutron-irradiated inside a nuclear reactor and was administered once intraperitoneally to uninfected and L. amazonensis-infected BALB/c mice. Different organs and tissues were collected and the total antimony was measured. Results: Higher antimony levels were found in infected than... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cutaneous leishmaniasis; Meglumine antimoniate; Pharmacokinetics; Biodistribution; Antimony; Radioisotope. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100304 In Vitro antileishmanial properties of neutron-irradiated meglumine antimoniate BABT Borborema,Samanta Etel Treiger; Andrade Junior,Heitor Franco de; Osso Junior,João Alberto; Nascimento,Nanci do. Pentavalent antimony, as meglumine antimoniate (Glucantime® ) or sodium stibogluconate (Pentostam® ), is the main treatment for leishmaniasis, a complex of diseases caused by the protozoan Leishmania, and an endemic and neglected threat in Brazil. Despite over half a century of clinical use, their mechanism of action, toxicity and pharmacokinetic data remain unknown. The analytical methods for determination of antimony in biological systems remain complex and have low sensitivity. Radiotracer studies have a potential in pharmaceutical development. The aim of this study was to obtain a radiotracer for antimony, with suitable physical and biological properties. Meglumine antimoniate was neutron irradiated inside the IEA-R1 nuclear reactor, producing two... Tipo: Info:eu-repo/semantics/article Palavras-chave: Meglumine antimoniate; Leishmaniasis; Leishmania (L.) chagasi; Radiotracer. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700009 Registros recuperados: 2 Primeira ... 1 ... Última

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