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Effects of high molybdenum intake on 1,2-dimethylhydrazine-induced intestinal tumors in rats Biocell
Montenegro,M.A.; Sánchez Negrette,M.; Gimeno,E.J.; Borda,J.T..
Wistar male rats, 3 months of age were given ad-libitum a nutritionally adequate diet and demineralized drinking water. The Molybdenum (Mo) and Tungsten (W) were provided in the drinking water at 200 ppm concentration. Intestinal tumors were induced by 1,2-dimethylhydrazine (DMH) given subcuta-neously as 16 weekly doses at 20 mg/kg body weight. Mo in the form of (NH 4 ) 6 Mo 7 O 24 4H 2 O or W in the form of (Na 2 WO 4 ) were provided in the drinking water two months before the first DMH treatment and were continued during 4 months more until the last DMH treatment. Three months after the last carcinogen injec-tion, all animals were sacrificed and examined for intestinal tumors. The number, size and location of the tumors were recorded and the pathology...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Intestinal cancer Molybdenum 1; 2-dimethylhydrazine Rats.
Ano: 2002 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452002000300004
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