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	Provedor de dados ArchiMer (3) Autor Berthou, Christian (3) Boisset, Claire (3) Bordron, Anne (3) Courtois, Anthony (3) Guezennec, Jean (3) Deslandes, Eric (1) Gac Breton, Stephanie (1) Simon-colin, Christelle (1) Mais... Palavra-chave 3)Gal epitope immunogenic oligosaccharide immunotherapy non-Hodgkin lymphoma xenoantigen (1) Alpha galactosyl glycerol (1) Complement system (1) Complement system Gal alpha(1 -> (1) Immunomodulation (1) Marine algae (1) Mais... Tipo do documento Text (3) Ano 2014 (1) 2012 (1) 2008 (1) País France (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Complement dependent cytotoxicity activity of therapeutic antibody fragments is acquired by immunogenic glycan coupling ArchiMer Courtois, Anthony; Gac Breton, Stephanie; Berthou, Christian; Guezennec, Jean; Bordron, Anne; Boisset, Claire. Oligosaccharides are implicated in the development of the immune response notably in complement activation. Anti-tumoural immunotherapy by monoclonal antibodies (mAbs) offers some advantages to chemotherapy including cell targeting but some of them are inefficient to generate cytotoxicity dependent complement (CDC) known to be important in the antibody's efficacy. The aim of this study is to give a CDC activity of mAb by linkage of a complement activating oligosaccharide to this antibody via a hetero-bifunctional linker allowing control of the conjugation reaction. We worked on non Hodgkin Burkitt's lymphoma as cancer source, Fab fragments of rituximab devoid of complement activity as mAb and the trisaccharide Gal alpha(1 -> 3)Gal beta(1 -> 4)GlcNAc... Tipo: Text Palavras-chave: Complement system Gal alpha(1 ->; 3)Gal epitope immunogenic oligosaccharide immunotherapy non-Hodgkin lymphoma xenoantigen. Ano: 2012 URL: http://archimer.ifremer.fr/doc/00125/23599/21423.pdf Floridoside extracted from the red alga Mastocarpus stellatus is a potent activator of the classical complement pathway ArchiMer Courtois, Anthony; Simon-colin, Christelle; Boisset, Claire; Berthou, Christian; Deslandes, Eric; Guezennec, Jean; Bordron, Anne. Many biological properties of algae have been found to have useful applications in human health, particularly in the fields of oncology and immunology. Floridoside, extracted from the red alga Mastocarpus stellatus, has a structure similar to the xenoantigen Gal alpha 1-3 Gal. This xenoantigen has been described to induce a high immune response in human xenografts and is mediated by natural anti-gal antibodies that activate the classical complement pathway. Based on this property, we analyzed the potential activities of floridoside on the immune system. We demonstrated that floridoside activates a complement cascade via the classical complement pathway, through the recruitment and activation of natural IgM. This algal molecule could represent an important... Tipo: Text Palavras-chave: Complement system; Immunomodulation; Marine algae; Alpha galactosyl glycerol. Ano: 2008 URL: http://archimer.ifremer.fr/doc/2008/publication-6248.pdf Exopolysaccharides Isolated from Hydrothermal Vent Bacteria Can Modulate the Complement System ArchiMer Courtois, Anthony; Berthou, Christian; Guezennec, Jean; Boisset, Claire; Bordron, Anne. The complement system is involved in the defence against bacterial infection, or in the elimination of tumour cells. However, disturbances in this system contributes to the pathogenesis of various inflammatory diseases. The efficiency of therapeutic anti-tumour antibodies is enhanced when the complement system is stimulated. In contrast, cancer cells are able to inhibit the complement system and thus proliferate. Some marine molecules are currently being developed as new drugs for use in humans. Among them, known exopolyssacharides (EPSs) generally originate from fungi, but few studies have been performed on bacterial EPSs and even fewer on EPSs extracted from deep-sea hydrothermal vent microbes. For use in humans, these high molecular weight EPSs must be... Tipo: Text Ano: 2014 URL: http://archimer.ifremer.fr/doc/00198/30963/29337.pdf Registros recuperados: 3 Primeira ... 1 ... Última

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