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Early weaning impairs body composition in male mice BJPS
Borges,Maria Carolina; Rogero,Marcelo Macedo; Pires,Ivanir Santana de Oliveira; Borelli,Primavera; Tirapegui,Julio.
This study aimed to evaluate the effect of early weaning on body composition and on parameters related to nutritional status in mice. The experimental group consisted of male Swiss Webster mice that were weaned early (at postnatal day fourteen) and fed an appropriate diet for growing rodents until postnatal day twenty-one (EW group). The control group consisted of male mice breastfed until postnatal day twenty-one (CON group). All animals were sacrificed on the twenty-first day of life. The EW group showed a decrease in liver and muscle protein content and concentration, brain protein concentration, brain DNA content and concentration, as well as liver and muscle protein/RNA ratio (p<0.05). Concerning body composition, the EW mice showed increased...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Weaning; Body composition; Breastfeeding; Nutritional status.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400026
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Celebrating the 120th anniversary of the School of Pharmaceutical Sciences of the University of São Paulo BJPS
Borelli,Primavera.
Tipo: Info:eu-repo/semantics/other
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000700100
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Hemathology BJPS
Borelli,Primavera.
Tipo: Info:eu-repo/semantics/review
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100030
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The influence of protein malnutrition on the production of GM-CSF and M-CSF by macrophages BJPS
Oliveira,Dalila Cunha de; Hastreiter,Araceli Aparecida; Borelli,Primavera; Fock,Ricardo Ambrósio.
ABSTRACT It is well established that protein malnutrition (PM) impairs immune defenses and increases susceptibility to infection. Macrophages are cells that play a central role in innate immunity, constituting one of the first barriers against infections. Macrophages produce several soluble factors, including cytokines and growth factors, important to the immune response. Among those growth factors, granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF). GM-CSF and M-CSF are important to monocyte and macrophage development and stimulation of the immune response process. Knowing the importance of GM-CSF and M-CSF, we sought to investigate the influence of PM on macrophage production of these growth...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Protein malnutrition; Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF); Macrophage Colony-Stimulating Factor (M-CSF).
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300375
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Short-term high-fat diet affects macrophages inflammatory response, early signs of a long-term problem BJPS
Santos,Ed Wilson; Oliveira,Dalila Cunha; Hastreiter,Araceli; Silva,Graziela Batista; Beltran,Jackeline Soares de Oliveira; Rogero,Marcelo Macedo; Fock,Ricardo Ambrósio; Borelli,Primavera.
Obesity is a chronic inflammatory disease that affects millions of people worldwide. Most studies observe the effects of a high-fat diet (HFD) in 10-12 weeks. This work investigated the effects induced by a HFD administered for 6 weeks on the nutritional status of mice and some aspects of the inflammatory response in mouse peritoneal macrophages. Male Swiss Webster mice, 2-3 months of age, were fed a control diet or HFD for 6 weeks. After this period, the mice were euthanized, and peritoneal macrophages were collected for immunoassays and assessment of biochemical parameters. A HFD was associated with increased cholesterol, insulin resistance, C-reactive protein (CRP), leptin, and serum resistin levels. Lipopolysaccharide (LPS)- stimulated adipocyte...
Tipo: Info:eu-repo/semantics/article Palavras-chave: High-fat diet/study; Mice; Macrophages; Metabolic syndrome; NF-kB..
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100548
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