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	Provedor de dados BJID (2) Autor Borges,Larissa Maria Guimarães (2) Vieira,José Luiz Fernandes (2) Ferreira,Michelle Valéria Dias (1) Gomes,Andreza de L.S. (1) Gomes,Margarete do Socorro Mendonça (1) Nascimento,Margareth Tavares Silva (1) Rivera,Juan Gonzalo Bardarez (1) Mais... Palavra-chave Falciparum malaria (1) Infectious disease (1) Malaria (1) Mefloquine (1) Parasitology (1) Quinine (1) Treatment (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2016 (1) 2008 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Patient age does not affect mefloquine concentrations in erythrocytes and plasma during the acute phase of falciparum malaria BJID Vieira,José Luiz Fernandes; Borges,Larissa Maria Guimarães; Ferreira,Michelle Valéria Dias; Rivera,Juan Gonzalo Bardarez; Gomes,Margarete do Socorro Mendonça. Abstract Objective To evaluate whether patient age has a significant impact on mefloquine concentrations in the plasma and erythrocytes over the course of treatment for uncomplicated falciparum malaria. Methods A total of 20 children aged between 8 and 11 years and 20 adult males aged between 22 and 41 years with uncomplicated falciparum malaria were enrolled in the study. Mefloquine was administered to patients in both age groups at a dose of 20 mg kg−1. The steady-state drug concentrations were measured by reversed-phase high performance liquid chromatography. Results All patients had an undetectable mefloquine concentration on day 0. In adults, the plasma mefloquine concentrations ranged from 770 to 2930 ng mL−1 and the erythrocyte concentrations... Tipo: Info:eu-repo/semantics/article Palavras-chave: Malaria; Infectious disease; Parasitology; Mefloquine. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500482 Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil BJID Vieira,José Luiz Fernandes; Borges,Larissa Maria Guimarães; Nascimento,Margareth Tavares Silva; Gomes,Andreza de L.S.. We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline was used. We measured the quinine in the plasma samples on days 0 and 3by high performance liquid chromatography. The mean concentration of quinine was 6.04 ±2.21 µg/mL in male patients and 5.98 ±1.95 µg/mL in female patients. No significant differences in quinine concentration were observed between these two groups. All samples collected before starting treatment were negative for quinine. This information could help in the development of strategies for the rational use of antimalarial drugs in Brazil. Tipo: Info:eu-repo/semantics/article Palavras-chave: Falciparum malaria; Quinine; Treatment. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500001 Registros recuperados: 2 Primeira ... 1 ... Última

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