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| Medeiros,Tessio David de; Pereira,Annyelly Tavares; Silva,Flavio Santos da; Bortolin,Raul Hernandes; Taveira,Karinna Veríssimo Meira; Abreu,Bento João da Graça Azevedo; Rezende,Adriana Augusto de; Farias,Naisandra Bezerra da Silva; Barbosa Filho,José Maria; Medeiros,Karina Carla de Paula. |
| Diabetes Mellitus (DM) is a metabolic syndrome characterized by hyperglycemia. Chronic complications affect a number of organs, including the lungs. Cissampelos sympodialis Eichl (Menispermaceae) is a plant used to treat respiratory diseases. The aim of this study was to evaluate the effect of Cissampelos sympodialis extract (CSE) in lungs of diabetic rats. We used 30 Wistar rats divided into three groups: control group (CG), diabetic group (DG) and diabetic Cissampelos sympodialis treatment group (DTG). Diabetes was induced by streptozotocin (40 mg/kg i.v.). The CSE (400 mg/kg, po) was administered daily, during four weeks, beginning one week after the onset of DM. The treatment with CSE was not able to reduce blood glucose levels after streptozotocin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cissampelos sympodialis; Diabetes; Lung; Pancreatic islets; Lipid profile. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100505 |
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| Loureiro,Melina Bezerra; Ururahy,Marcela Abbott Galvão; Souza,Karla Simone Costa de; Oliveira,Yonara Monique da Costa; Silva,Heglayne Pereira Vital da; Bortolin,Raul Hernandes; Bezerra,João Felipe; Hirata,Rosario Dominguez Crespo; Maciel-Neto,José Jorge; Arrais,Ricardo Fernando; Almeida,Maria das Graças; Hirata,Mario Hiroyuki; Rezende,Adriana Augusto de. |
| ABSTRACT The aim of the present study was to investigate the bone mineral density (BMD) of patients with type 1 Diabetes mellitus (T1DM). We also assessed the association between osteoprotegerin (OPG) genetic polymorphisms and BMD. Genotyping was performed for 1181G>C and 163A>G OPG polymorphisms by allelic discrimination in 119 patients with T1DM and 161 normoglycemic (NG) individuals, aged 6 to 20 years old. Glycemic control, serum parameters of bone metabolism and BMD were evaluated. T1DM patients showed low BMD, poor glycemic control and decreased total calcium values when compared to controls (p < 0.05). For all the polymorphisms studied, the genotype and allele frequencies in patients with T1DM were not significantly different from the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Type 1 Diabetes mellitus/bone biomarkers; Bone mineral density; OPG polymorphism/children and adolescents. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400616 |
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