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Chlamydia trachomatis and human papillomavirus coinfection: association with p16INK4a and Ki67 expression in biopsies of patients with pre-neoplastic and neoplastic lesions BJID
Calil,Luciane Noal; Igansi,Cristine Nascente; Meurer,Luise; Edelweiss,Maria Isabel Albano; Bozzetti,Mary Clarisse.
The objective of this study was to identify the frequency of coinfection by human papillomavirus (HPV) and Chlamydia trachomatis (CT) in cervical lesions and relate it with immunohistochemical expression of p16INK4a and Ki67, both oncogenicity markers. A cross-sectional study with 86 women from primary care units in southern Brazil was conducted. Cervical swabs were collected for HPV-DNA and CT-DNA detection, through the polymerase chain reaction technique (PCR). The immunohistochemical analysis was performed on biopsy cervical tissue material to identify the expression of p16INK4a and Ki67 cell cycle markers. About 83 % were positive for HPV-DNA and 19% had coinfection with CT-DNA. Among coinfected women, 56% expressed p16INK4a. There was a statistically...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Epidemiology; Human papillomavirus 16; Biomarkers; Pharmacological.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200006
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Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil BJID
Chedid,Maria Bernadete; Chedid,Márcio Fernandes; Ilha,Darcy Oliveira; Bozzetti,Mary Clarisse; Chaves,Letícia; Griza,Daniela; Dalcin,Paulo Roth.
As there was not any data on Chlamydia pneumoniae (TWAR) infections in Brazil so far, a prospective cohort study of adult patients hospitalized due to CAP was carried out for one year in a Brazilian university general hospital to detect the incidence of CAP by Chlamydophila pneumoniae (TWAR) for one year. During a whole year 645 consecutive patients hospitalized due to an initial presumptive diagnosis of respiratory diseases by ICD-10 (J00-J99), excluding upper respiratory diseases, were screened; 59 consecutive patients with CAP were diagnosed. They had determinations of serum antibodies to C. pneumoniae by microimmunofluorescence at the Infectious Diseases Laboratory of University of Louisville (KY, USA); 37 patients (63.8%) had seroreactivity to TWAR...
Tipo: Info:eu-repo/semantics/article Palavras-chave: CAP; Chlamydophila pneumoniae; Microimmunofluorescence; TWAR infections.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100018
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